General Information of Drug (ID: DMZL6Q1)

Drug Name
2-morpholino-6-(naphthalen-1-yl)-4H-chromen-4-one
Synonyms CHEMBL197475
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 357.4
Logarithm of the Partition Coefficient (xlogp) 4.4
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C23H19NO3
IUPAC Name
2-morpholin-4-yl-6-naphthalen-1-ylchromen-4-one
Canonical SMILES
C1COCCN1C2=CC(=O)C3=C(O2)C=CC(=C3)C4=CC=CC5=CC=CC=C54
InChI
InChI=1S/C23H19NO3/c25-21-15-23(24-10-12-26-13-11-24)27-22-9-8-17(14-20(21)22)19-7-3-5-16-4-1-2-6-18(16)19/h1-9,14-15H,10-13H2
InChIKey
ALYIMYTWUBXFRH-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
11646132
TTD ID
D0XL6P

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA-dependent protein kinase catalytic (PRKDC) TTK3PY9 PRKDC_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46.