Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DT0HW5C)

DTP Name Mitochondrial uncoupling protein 4 (SLC25A27)
Gene Name SLC25A27
UniProt ID
O95847 (UCP4_HUMAN)
VARIDT ID
DTD0188
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms SLC25A27; Solute carrier family 25 member 27; UCP 4; UCP4; UNQ772/PRO1566
DTP Family Mitochondrial Carrier (MC) Family ;
Tissue Specificity Found in adult and fetal brain. Present inmost of the brain tissues, with low levels in spinal chord, corpuscallosum and substantia nigra.
Sequence
MSVPEEEERLLPLTQRWPRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGD
GARESAPYRGMVRTALGIIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKS
EDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKI
LAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGL
VASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRM
TPWSMVFWLTYEKIREMSGVSPF
Function
This transporter is mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. It may play a role in thermoregulatory heat production and metabolism in brain.
Endogenous Substrate(s) H+; Cl-
TCDB ID
2.A.29.24.3
Gene ID
9481
Reactome Pathway
The proton buffering model (R-HSA-167827 )
The fatty acid cycling model (R-HSA-167826 )

Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 6.88E-01 -8.64E-03 -8.59E-02
Adrenocortical carcinoma 2D11.Z Kidney 1.96E-03 2.76E-01 8.62E-01
Alopecia ED70 Skin from scalp 3.15E-01 6.97E-02 2.14E-01
Alzheimer's disease 8A20 Entorhinal cortex 5.24E-08 -2.78E-01 -5.73E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 6.50E-01 -7.45E-02 -5.18E-01
Aortic stenosis BB70 Calcified aortic valve 7.09E-02 -3.08E-01 -6.05E-01
Apnea 7A40 Hyperplastic tonsil 1.86E-01 -1.19E-01 -7.09E-01
Arthropathy FA00-FA5Z Peripheral blood 4.37E-01 -4.42E-02 -4.80E-01
Asthma CA23 Nasal and bronchial airway 3.20E-08 -5.17E-01 -8.19E-01
Atopic dermatitis EA80 Skin 3.34E-01 -4.72E-02 -1.81E-01
Autism 6A02 Whole blood 2.49E-01 2.00E-02 2.32E-01
Autoimmune uveitis 9A96 Peripheral monocyte 7.25E-02 1.06E-01 9.07E-01
Autosomal dominant monocytopenia 4B04 Whole blood 6.02E-01 -1.26E-01 -9.23E-01
Bacterial infection of gingival 1C1H Gingival tissue 3.13E-02 -8.03E-02 -4.24E-01
Batten disease 5C56.1 Whole blood 1.55E-01 -1.45E-01 -1.10E+00
Behcet's disease 4A62 Peripheral blood 1.29E-01 -5.85E-02 -3.23E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 6.96E-01 6.00E-02 1.08E-01
Bladder cancer 2C94 Bladder tissue 1.46E-03 -5.50E-01 -2.49E+00
Breast cancer 2C60-2C6Z Breast tissue 1.01E-15 -2.60E-01 -4.36E-01
Cardioembolic stroke 8B11.20 Whole blood 4.71E-01 2.67E-02 1.32E-01
Cervical cancer 2C77 Cervical tissue 2.81E-03 -3.70E-01 -1.06E+00
Childhood onset rheumatic disease FA20.Z Peripheral blood 9.89E-01 2.01E-02 1.56E-01
Chronic hepatitis C 1E51.1 Whole blood 1.23E-01 5.04E-02 4.35E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 5.00E-01 6.14E-02 1.74E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 2.38E-02 -1.35E-01 -2.79E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 5.12E-03 -5.18E-01 -1.71E+00
Colon cancer 2B90 Colon tissue 3.22E-65 3.64E-01 1.83E+00
Coronary artery disease BA80-BA8Z Peripheral blood 7.39E-01 1.31E-02 2.05E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 8.71E-01 1.48E-01 2.96E-01
Endometriosis GA10 Endometrium tissue 1.67E-01 4.59E-02 1.04E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 2.15E-01 -3.15E-02 -3.77E-01
Familial hypercholesterolemia 5C80.00 Whole blood 3.61E-01 -4.88E-02 -4.56E-01
Gastric cancer 2B72 Gastric tissue 4.53E-01 -3.45E-01 -5.99E-01
Glioblastopma 2A00.00 Nervous tissue 2.22E-68 -7.66E-01 -1.20E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 2.68E-01 -4.15E-01 -8.06E-01
Head and neck cancer 2D42 Head and neck tissue 5.73E-10 -2.17E-01 -4.48E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 5.93E-01 1.37E-01 3.08E-01
Huntington's disease 8A01.10 Whole blood 8.50E-01 2.08E-02 1.72E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 1.60E-01 4.26E-01 9.41E-01
Immunodeficiency 4A00-4A20 Peripheral blood 7.91E-01 -5.45E-02 -4.88E-01
Influenza 1.00E+30 Whole blood 6.16E-01 3.72E-02 3.17E-01
Interstitial cystitis GC00.3 Bladder tissue 1.01E-01 -2.18E-01 -1.20E+00
Intracranial aneurysm 8B01.0 Intracranial artery 5.92E-03 -2.32E-01 -9.07E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 6.07E-01 -1.49E-02 -4.05E-02
Ischemic stroke 8B11 Peripheral blood 7.38E-01 -3.84E-03 -3.21E-02
Juvenile idiopathic arthritis FA24 Peripheral blood 1.42E-02 7.39E-02 3.29E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 2.54E-01 -1.39E-01 -8.29E-01
Lateral sclerosis 8B60.4 Skin 4.47E-01 1.95E-01 6.87E-01
Liver cancer 2C12.0 Liver tissue 8.69E-02 -9.93E-02 -1.99E-01
Liver failure DB99.7-DB99.8 Liver tissue 3.33E-03 -3.03E-01 -1.34E+00
Lung cancer 2C25 Lung tissue 1.12E-01 -1.95E-02 -7.24E-02
Lupus erythematosus 4A40 Whole blood 3.86E-01 2.12E-02 1.26E-01
Major depressive disorder 6A70-6A7Z Whole blood 6.98E-03 1.60E-01 8.77E-01
Major depressive disorder 6A70-6A7Z Hippocampus 3.75E-01 -2.59E-02 -4.91E-02
Melanoma 2C30 Skin 2.62E-01 -4.31E-01 -3.72E-01
Multiple myeloma 2A83.1 Bone marrow 4.99E-03 -2.09E-01 -1.92E+00
Multiple myeloma 2A83.1 Peripheral blood 5.77E-01 3.98E-02 4.48E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 4.88E-02 2.25E-01 9.50E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 6.10E-03 -2.62E-02 -2.08E-01
Myelofibrosis 2A20.2 Whole blood 7.50E-01 6.85E-02 6.90E-01
Myocardial infarction BA41-BA50 Peripheral blood 2.30E-01 3.29E-02 1.11E-01
Myopathy 8C70.6 Muscle tissue 1.05E-01 9.89E-02 7.02E-01
Neonatal sepsis KA60 Whole blood 1.63E-02 6.42E-02 4.84E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 1.35E-01 4.78E-02 1.27E-01
Non-alcoholic fatty liver disease DB92 Liver tissue 6.05E-01 3.49E-04 2.42E-03
Obesity related type 2 diabetes 5A11 Omental adipose tissue 3.26E-01 -2.89E-01 -7.08E-01
Olive pollen allergy CA08.00 Peripheral blood 8.65E-01 -1.00E-02 -4.32E-02
Oral cancer 2B6E Oral tissue 2.86E-02 -1.02E-01 -3.49E-01
Osteoarthritis FA00-FA0Z Synovial tissue 7.75E-02 -3.72E-01 -1.06E+00
Osteoporosis FB83.1 Bone marrow 9.68E-01 1.16E-01 2.99E-01
Ovarian cancer 2C73 Ovarian tissue 7.16E-02 -8.52E-01 -8.59E-01
Pancreatic cancer 2C10 Pancreas 9.84E-01 -5.04E-02 -1.22E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 4.41E-01 -1.79E-02 -3.14E-02
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 3.39E-01 -1.59E-03 -2.40E-02
Pituitary cancer 2D12 Pituitary tissue 7.69E-02 -4.04E-01 -9.83E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 1.45E-01 4.12E-01 1.17E+00
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 5.25E-01 -1.97E-02 -1.45E-01
Polycythemia vera 2A20.4 Whole blood 2.35E-04 8.32E-02 9.10E-01
Pompe disease 5C51.3 Biceps muscle 2.78E-01 1.14E-01 5.70E-01
Preterm birth KA21.4Z Myometrium 5.93E-01 2.52E-01 1.34E+00
Prostate cancer 2C82 Prostate 1.84E-03 5.15E-01 6.36E-01
Psoriasis EA90 Skin 5.99E-08 1.90E-01 4.85E-01
Rectal cancer 2B92 Rectal colon tissue 7.05E-03 1.30E-01 6.01E-01
Renal cancer 2C90-2C91 Kidney 9.22E-01 -1.65E-01 -3.53E-01
Retinoblastoma 2D02.2 Uvea 1.85E-05 -2.08E+00 -5.81E+00
Rheumatoid arthritis FA20 Synovial tissue 9.44E-02 1.09E-01 5.11E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 1.93E-01 -1.44E-02 -1.25E-01
Schizophrenia 6A20 Prefrontal cortex 2.86E-02 -4.62E-01 -3.93E-01
Schizophrenia 6A20 Superior temporal cortex 3.63E-01 2.49E-02 7.38E-02
Scleroderma 4A42.Z Whole blood 4.80E-01 2.53E-02 1.99E-01
Seizure 8A60-8A6Z Whole blood 4.68E-01 4.82E-02 5.48E-01
Sensitive skin EK0Z Skin 6.46E-01 -1.07E-01 -1.13E+00
Sepsis with septic shock 1G41 Whole blood 4.25E-01 -1.30E-02 -9.65E-02
Shwachman-Diamond syndrome 3A70.0 Bone marrow 4.60E-01 -3.85E-02 -2.38E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 6.19E-02 5.17E-02 8.33E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 9.94E-01 8.67E-02 4.81E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 7.66E-01 -6.62E-02 -3.19E-01
Skin cancer 2C30-2C3Z Skin 2.18E-08 3.81E-01 5.99E-01
Thrombocythemia 3B63 Whole blood 6.31E-02 7.87E-02 7.30E-01
Thrombocytopenia 3B64 Whole blood 5.23E-02 3.16E-01 1.44E+00
Thyroid cancer 2D10 Thyroid 2.79E-02 1.34E-01 4.04E-01
Tibial muscular dystrophy 8C75 Muscle tissue 1.94E-02 -3.61E-01 -1.79E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 5.14E-05 -1.91E+00 -6.17E+00
Type 2 diabetes 5A11 Liver tissue 1.70E-01 -3.90E-01 -1.04E+00
Ureter cancer 2C92 Urothelium 6.92E-01 5.08E-02 3.24E-01
Uterine cancer 2C78 Endometrium tissue 1.74E-01 -1.75E-01 -2.90E-01
Vitiligo ED63.0 Skin 5.38E-03 3.78E-01 1.63E+00
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