Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DT18YD9)

• DTP Name: Glucose transporter type 14 (SLC2A14)
• Gene Name: SLC2A14
• UniProt ID: Q8TDB8 (GTR14_HUMAN)
• VARIDT ID: DTD0256
• Synonyms: GLUT-14; GLUT14; SLC2A14; SLC2A3P3; Solute carrier family 2, facilitated glucose transporter member 14
• DTP Family:
  Major Facilitator Superfamily (MFS)
  Sugar Porter (SP) Family
• Tissue Specificity: Expressed mainly in testis.
• Sequence:
  MEFHNGGHVSGIGGFLVSLTSRMKPHTLAVTPALIFAITVATIGSFQFGYNTGVINAPET
  IIKEFINKTLTDKANAPPSEVLLTNLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLI
  VNLLAATGGCLMGLCKIAESVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGT
  LNQLGIVIGILVAQIFGLELILGSEELWPVLLGFTILPAILQSAALPCCPESPRFLLINR
  KKEENATRILQRLWGTQDVSQDIQEMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVL
  QLSQQLSGINAVFYYSTGIFKDAGVQQPIYATISAGVVNTIFTLLSLFLVERAGRRTLHM
  IGLGGMAFCSTLMTVSLLLKNHYNGMSFVCIGAILVFVACFEIGPGPIPWFIVAELFSQG
  PRPAAMAVAGCSNWTSNFLVGLLFPSAAYYLGAYVFIIFTGFLITFLAFTFFKVPETRGR
  TFEDITRAFEGQAHGADRSGKDGVMGMNSIEPAKETTTNV
• Function: This transporter may have a specific function related to spermatogenesis and facilitates glucose transport.
• Endogenous Substrate(s): Glucose
• TCDB ID: 2.A.1.1.90
• Gene ID: 144195
• Reactome Pathway: Cellular hexose transport (R-HSA-189200)

Molecular Interaction Atlas (MIA) of This DTP

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[1]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
dehydroascorbic acid	DMKYQO4	Discovery agent	N.A.	Investigative	[1]

References

• [1] The SLC2A14 gene, encoding the novel glucose/dehydroascorbate transporter GLUT14, is associated with inflammatory bowel disease. Am J Clin Nutr. 2017 Dec;106(6):1508-1513.