Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DT2I7BM)

DTP Name Glucose transporter type 8 (SLC2A8)
Gene Name SLC2A8
UniProt ID
Q9NY64 (GTR8_HUMAN)
VARIDT ID
DTD0266
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms GLUT-8; GLUT8; GLUTX1; Glucose transporter type X1; SLC2A8; Solute carrier family 2, facilitated glucose transporter member 8
DTP Family Major Facilitator Superfamily (MFS)
Sugar Porter (SP) Family
Tissue Specificity Highly expressed in testis, but not intesticular carcinoma. Lower amounts present in most other tissues.
Sequence
MTPEDPEETQPLLGPPGGSAPRGRRVFLAAFAAALGPLSFGFALGYSSPAIPSLQRAAPP
APRLDDAAASWFGAVVTLGAAAGGVLGGWLVDRAGRKLSLLLCSVPFVAGFAVITAAQDV
WMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVVGILLAYLAGWVLE
WRWLAVLGCVPPSLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLWGSEQGWEDPPIGAE
QSFHLALLRQPGIYKPFIIGVSLMAFQQLSGVNAVMFYAETIFEEAKFKDSSLASVVVGV
IQVLFTAVAALIMDRAGRRLLLVLSGVVMVFSTSAFGAYFKLTQGGPGNSSHVAISAPVS
AQPVDASVGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWLM
AFLVTKEFSSLMEVLRPYGAFWLASAFCIFSVLFTLFCVPETKGKTLEQITAHFEGR
Function
This insulin-regulated transporter facilitates glucose transport and binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose.
Endogenous Substrate(s) Glucose
TCDB ID
2.A.1.1.89
Gene ID
29988
Reactome Pathway
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825 )
Clathrin-mediated endocytosis (R-HSA-8856828 )
Cellular hexose transport (R-HSA-189200 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
1 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [1]
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Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 7.62E-01 -2.38E-02 -1.44E-01
Adrenocortical carcinoma 2D11.Z Kidney 2.71E-01 -2.78E-02 -8.98E-02
Alopecia ED70 Skin from scalp 3.32E-02 2.40E-01 7.42E-01
Alzheimer's disease 8A20 Entorhinal cortex 3.53E-01 -4.98E-02 -1.96E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 7.73E-01 -7.98E-02 -3.01E-01
Aortic stenosis BB70 Calcified aortic valve 3.97E-01 1.41E-01 4.09E-01
Apnea 7A40 Hyperplastic tonsil 1.15E-01 -3.34E-01 -4.10E+00
Arthropathy FA00-FA5Z Peripheral blood 1.41E-01 -1.07E-01 -7.71E-01
Asthma CA23 Nasal and bronchial airway 1.43E-04 3.91E-01 6.05E-01
Atopic dermatitis EA80 Skin 2.77E-03 2.03E-01 9.18E-01
Autism 6A02 Whole blood 3.65E-01 -3.20E-02 -2.32E-01
Autoimmune uveitis 9A96 Peripheral monocyte 4.18E-01 1.89E-02 1.06E-01
Autosomal dominant monocytopenia 4B04 Whole blood 1.47E-01 4.27E-02 2.43E-01
Bacterial infection of gingival 1C1H Gingival tissue 9.76E-01 -1.19E-02 -5.88E-02
Batten disease 5C56.1 Whole blood 1.40E-01 1.53E-01 7.65E-01
Behcet's disease 4A62 Peripheral blood 4.85E-01 -5.13E-02 -2.70E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 2.38E-01 6.42E-02 3.16E-01
Bladder cancer 2C94 Bladder tissue 1.39E-02 -3.95E-01 -1.62E+00
Breast cancer 2C60-2C6Z Breast tissue 4.20E-01 1.26E-02 3.79E-02
Cardioembolic stroke 8B11.20 Whole blood 7.91E-01 -1.94E-02 -5.76E-02
Cervical cancer 2C77 Cervical tissue 6.10E-01 -7.63E-02 -3.74E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 2.02E-01 4.41E-02 3.61E-01
Chronic hepatitis C 1E51.1 Whole blood 5.91E-01 -8.27E-02 -3.01E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 3.91E-01 -3.16E-02 -1.07E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 8.99E-01 5.44E-02 2.57E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 1.59E-02 1.45E-01 2.41E+00
Colon cancer 2B90 Colon tissue 5.26E-59 3.90E-01 1.81E+00
Coronary artery disease BA80-BA8Z Peripheral blood 2.61E-01 -3.22E-01 -9.65E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 3.37E-01 7.32E-03 4.60E-02
Endometriosis GA10 Endometrium tissue 8.61E-01 -6.64E-02 -1.27E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 7.16E-01 -6.92E-03 -5.59E-02
Familial hypercholesterolemia 5C80.00 Whole blood 2.67E-01 1.00E-02 5.85E-02
Gastric cancer 2B72 Gastric tissue 4.58E-01 -1.57E-01 -2.17E-01
Glioblastopma 2A00.00 Nervous tissue 1.93E-48 -3.12E-01 -9.81E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 5.70E-01 1.72E-01 5.22E-01
Head and neck cancer 2D42 Head and neck tissue 8.16E-01 -2.76E-02 -1.75E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 2.35E-01 1.11E-01 4.00E-01
Huntington's disease 8A01.10 Whole blood 7.42E-01 2.10E-02 1.13E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 7.05E-01 3.09E-02 9.74E-02
Immunodeficiency 4A00-4A20 Peripheral blood 1.44E-01 4.52E-02 4.73E-01
Influenza 1.00E+30 Whole blood 3.13E-01 4.03E-02 3.24E-01
Interstitial cystitis GC00.3 Bladder tissue 8.12E-02 -1.62E-01 -9.45E-01
Intracranial aneurysm 8B01.0 Intracranial artery 9.95E-03 2.39E-01 1.40E+00
Irritable bowel syndrome DD91.0 Rectal colon tissue 1.53E-01 -7.76E-02 -1.91E-01
Ischemic stroke 8B11 Peripheral blood 3.01E-01 -8.13E-02 -4.44E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 2.25E-02 -1.25E-01 -4.98E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 5.93E-01 3.25E-04 1.13E-03
Lateral sclerosis 8B60.4 Skin 4.11E-01 1.11E-01 5.51E-01
Liver cancer 2C12.0 Liver tissue 4.38E-03 -9.50E-02 -3.01E-01
Liver failure DB99.7-DB99.8 Liver tissue 5.50E-01 9.29E-02 2.28E-01
Lung cancer 2C25 Lung tissue 4.57E-05 -1.21E-01 -4.42E-01
Lupus erythematosus 4A40 Whole blood 9.38E-04 -1.13E-01 -3.67E-01
Major depressive disorder 6A70-6A7Z Whole blood 7.11E-01 2.93E-02 1.36E-01
Major depressive disorder 6A70-6A7Z Hippocampus 6.25E-01 3.22E-02 1.56E-01
Melanoma 2C30 Skin 2.64E-01 -3.34E-01 -5.02E-01
Multiple myeloma 2A83.1 Bone marrow 9.06E-04 3.28E-01 1.59E+00
Multiple myeloma 2A83.1 Peripheral blood 7.64E-01 -1.16E-02 -5.98E-02
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 4.79E-01 -5.97E-02 -1.30E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 3.38E-05 1.32E-01 9.24E-01
Myelofibrosis 2A20.2 Whole blood 2.08E-01 3.63E-02 1.95E-01
Myocardial infarction BA41-BA50 Peripheral blood 9.29E-01 2.56E-02 7.46E-02
Myopathy 8C70.6 Muscle tissue 8.54E-03 -3.27E-01 -1.46E+00
Neonatal sepsis KA60 Whole blood 1.45E-03 -1.19E-01 -5.84E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 3.80E-01 7.85E-02 3.33E-01
Non-alcoholic fatty liver disease DB92 Liver tissue 8.67E-01 -4.37E-02 -1.96E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 5.77E-01 8.70E-04 1.14E-02
Olive pollen allergy CA08.00 Peripheral blood 2.28E-01 1.29E-01 2.88E-01
Oral cancer 2B6E Oral tissue 4.71E-05 -2.62E-01 -1.33E+00
Osteoarthritis FA00-FA0Z Synovial tissue 3.60E-01 -3.47E-02 -1.47E-01
Osteoporosis FB83.1 Bone marrow 2.42E-01 1.01E-01 6.50E-01
Ovarian cancer 2C73 Ovarian tissue 7.53E-01 -1.33E-01 -8.39E-01
Pancreatic cancer 2C10 Pancreas 5.84E-01 -1.16E-02 -3.41E-02
Parkinson's disease 8A00.0 Substantia nigra tissue 4.02E-01 7.91E-02 4.90E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 6.95E-02 -4.71E-02 -3.69E-01
Pituitary cancer 2D12 Pituitary tissue 3.11E-03 2.78E-01 1.38E+00
Pituitary gonadotrope tumour 2D12 Pituitary tissue 2.96E-01 -2.96E-02 -1.40E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 9.02E-02 -7.45E-02 -6.53E-01
Polycythemia vera 2A20.4 Whole blood 7.30E-03 1.36E-01 7.87E-01
Pompe disease 5C51.3 Biceps muscle 5.17E-01 -1.68E-01 -5.54E-01
Preterm birth KA21.4Z Myometrium 5.78E-01 1.48E-01 4.45E-01
Prostate cancer 2C82 Prostate 1.15E-01 2.07E-01 4.86E-01
Psoriasis EA90 Skin 2.29E-11 1.89E-01 7.87E-01
Rectal cancer 2B92 Rectal colon tissue 3.46E-04 2.83E-01 1.95E+00
Renal cancer 2C90-2C91 Kidney 2.06E-01 6.81E-02 3.35E-01
Retinoblastoma 2D02.2 Uvea 8.15E-05 3.67E-01 3.12E+00
Rheumatoid arthritis FA20 Synovial tissue 2.01E-01 -1.85E-01 -5.04E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 4.52E-01 2.75E-02 1.28E-01
Schizophrenia 6A20 Prefrontal cortex 1.30E-02 -1.80E-01 -5.78E-01
Schizophrenia 6A20 Superior temporal cortex 2.37E-01 -5.95E-02 -4.02E-01
Scleroderma 4A42.Z Whole blood 1.43E-01 1.09E-01 7.06E-01
Seizure 8A60-8A6Z Whole blood 9.37E-01 -1.59E-02 -8.79E-02
Sensitive skin EK0Z Skin 2.14E-01 1.85E-01 1.23E+00
Sepsis with septic shock 1G41 Whole blood 2.12E-19 -2.01E-01 -8.83E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 9.83E-01 -1.01E-01 -6.37E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 7.91E-02 1.57E-01 7.63E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 8.64E-01 7.19E-02 1.86E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 7.40E-01 3.42E-02 1.27E-01
Skin cancer 2C30-2C3Z Skin 5.30E-03 -3.28E-02 -1.04E-01
Thrombocythemia 3B63 Whole blood 1.10E-01 8.76E-02 4.54E-01
Thrombocytopenia 3B64 Whole blood 7.38E-01 -1.35E-01 -2.10E-01
Thyroid cancer 2D10 Thyroid 2.04E-21 -4.01E-01 -1.42E+00
Tibial muscular dystrophy 8C75 Muscle tissue 3.34E-03 -2.22E-01 -8.45E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 2.48E-01 8.79E-02 3.80E-01
Type 2 diabetes 5A11 Liver tissue 5.20E-01 2.50E-02 1.11E-01
Ureter cancer 2C92 Urothelium 3.97E-01 9.44E-03 6.58E-02
Uterine cancer 2C78 Endometrium tissue 1.74E-18 -7.18E-01 -6.75E-01
Vitiligo ED63.0 Skin 6.24E-01 -9.47E-03 -2.32E-02
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⏷ Show the Full List of Expression Under 107 Diseases

Drug Affinity of This DTP Assessed by Cell Line

Approved Drug(s)
Drug Name Highest Status Cell Line Affinity REF
2-deoxyglucose Approved Xenopus oocytes-GLUT8 Km = 2000.0 microM [1]

References

1 Functional Properties and Genomics of Glucose Transporters. Curr Genomics. 2007 Apr; 8(2): 113128.