Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DT38SZL)

DTP Name Organic cation transporter-like 3 (SLC22A13)
Gene Name SLC22A13
UniProt ID
Q9Y226 (S22AD_HUMAN)
VARIDT ID
DTD0139
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms OAT10; OCTL1; OCTL3; ORCTL-3; ORCTL3; SLC22A13; Solute carrier family 22 member 13
DTP Family Major Facilitator Superfamily (MFS)
Organic Cation Transporter (OCT) Family
Tissue Specificity Ubiquitous, expressed at low levels.
Sequence
MAQFVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTF
NLSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQPCDMGWEYPENRL
PSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGL
ATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVL
AGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRR
KLSPELMNQLVPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGL
DVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPADLPVVVTM
LAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVILLGEYHAAL
PMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPRSPKSVPSEKETEAKGRTSS
PGVAFVSSTYF
Function This transporter can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine.
Endogenous Substrate(s) Nicotinate; Urate; Lactate; p-aminohippurate
TCDB ID
2.A.1.19.17
Gene ID
9390
Reactome Pathway
Nicotinamide salvaging (R-HSA-197264 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
1 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-glutamic acid DM4PUDW Schizophrenia 6A20 Approved [1]
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1 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspartic acid DMK7EYA Discovery agent N.A. Investigative [1]
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Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 4.15E-01 -6.68E-03 -3.15E-02
Adrenocortical carcinoma 2D11.Z Kidney 4.93E-02 -1.22E-01 -4.84E-01
Alopecia ED70 Skin from scalp 3.47E-02 -5.72E-02 -3.21E-01
Alzheimer's disease 8A20 Entorhinal cortex 4.56E-01 -9.51E-03 -3.68E-02
Ankylosing spondylitis FA92.0 Pheripheral blood 5.45E-01 -3.02E-02 -2.52E-01
Aortic stenosis BB70 Calcified aortic valve 5.28E-01 2.27E-01 3.85E-01
Apnea 7A40 Hyperplastic tonsil 9.18E-01 5.06E-03 4.40E-02
Arthropathy FA00-FA5Z Peripheral blood 4.09E-01 3.37E-02 2.25E-01
Asthma CA23 Nasal and bronchial airway 2.79E-01 -1.08E-01 -2.92E-01
Atopic dermatitis EA80 Skin 2.79E-01 -6.94E-02 -7.02E-01
Autism 6A02 Whole blood 8.69E-01 5.84E-02 1.67E-01
Autoimmune uveitis 9A96 Peripheral monocyte 2.10E-02 -2.41E-01 -3.11E+00
Autosomal dominant monocytopenia 4B04 Whole blood 1.73E-01 -7.54E-02 -1.10E-01
Bacterial infection of gingival 1C1H Gingival tissue 3.76E-01 -3.88E-03 -1.28E-02
Batten disease 5C56.1 Whole blood 4.83E-01 -3.95E-02 -3.75E-01
Behcet's disease 4A62 Peripheral blood 8.49E-01 2.70E-02 1.02E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 5.19E-01 -1.16E-01 -5.74E-01
Bladder cancer 2C94 Bladder tissue 3.28E-03 7.50E-01 2.05E+00
Breast cancer 2C60-2C6Z Breast tissue 5.09E-03 -8.07E-02 -2.27E-01
Cardioembolic stroke 8B11.20 Whole blood 8.51E-04 1.73E-01 8.06E-01
Cervical cancer 2C77 Cervical tissue 5.58E-01 4.79E-02 1.16E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 8.44E-01 -1.14E-01 -3.57E-01
Chronic hepatitis C 1E51.1 Whole blood 8.96E-01 -1.29E-02 -7.55E-02
Chronic obstructive pulmonary disease CA22 Lung tissue 3.12E-01 4.36E-02 2.37E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 1.04E-03 9.30E-02 3.83E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 8.81E-01 2.55E-02 1.34E-01
Colon cancer 2B90 Colon tissue 7.44E-06 -1.70E-01 -4.98E-01
Coronary artery disease BA80-BA8Z Peripheral blood 6.42E-01 -1.08E-01 -6.24E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 2.81E-01 1.18E-01 4.41E-01
Endometriosis GA10 Endometrium tissue 9.38E-01 -6.07E-02 -1.79E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 8.26E-01 7.51E-02 3.91E-01
Familial hypercholesterolemia 5C80.00 Whole blood 5.42E-01 -1.01E-01 -4.53E-01
Gastric cancer 2B72 Gastric tissue 8.24E-01 -1.72E-01 -2.80E-01
Glioblastopma 2A00.00 Nervous tissue 1.50E-75 -4.78E-01 -1.41E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 7.50E-04 -5.47E-01 -1.73E+00
Head and neck cancer 2D42 Head and neck tissue 3.56E-02 8.63E-02 3.09E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 4.87E-01 1.29E-02 3.93E-02
Huntington's disease 8A01.10 Whole blood 4.38E-01 1.32E-01 5.83E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 7.98E-01 2.05E-01 4.99E-01
Immunodeficiency 4A00-4A20 Peripheral blood 5.16E-01 1.03E-01 1.20E+00
Influenza 1.00E+30 Whole blood 3.90E-03 7.22E-01 8.13E+00
Interstitial cystitis GC00.3 Bladder tissue 8.30E-01 -3.33E-03 -3.44E-02
Intracranial aneurysm 8B01.0 Intracranial artery 9.36E-01 -8.80E-02 -5.37E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 1.94E-01 6.83E-02 2.51E-01
Ischemic stroke 8B11 Peripheral blood 2.30E-01 8.07E-02 3.78E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 2.69E-02 1.06E-01 4.83E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 5.20E-02 6.81E-01 1.76E+00
Lateral sclerosis 8B60.4 Skin 4.82E-01 -1.17E-01 -6.20E-01
Liver cancer 2C12.0 Liver tissue 4.53E-02 -1.63E-01 -3.71E-01
Liver failure DB99.7-DB99.8 Liver tissue 6.64E-01 1.03E-02 3.85E-02
Lung cancer 2C25 Lung tissue 1.63E-09 -1.53E-01 -5.99E-01
Lupus erythematosus 4A40 Whole blood 2.23E-03 -2.68E-01 -5.22E-01
Major depressive disorder 6A70-6A7Z Whole blood 8.08E-01 -1.41E-02 -4.77E-02
Major depressive disorder 6A70-6A7Z Hippocampus 1.21E-01 -1.10E-01 -5.02E-01
Melanoma 2C30 Skin 5.44E-01 4.66E-01 5.98E-01
Multiple myeloma 2A83.1 Bone marrow 2.08E-02 -3.49E-01 -1.04E+00
Multiple myeloma 2A83.1 Peripheral blood 7.75E-01 4.47E-02 2.56E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 8.91E-01 4.82E-02 1.54E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 1.97E-01 5.20E-02 2.95E-01
Myelofibrosis 2A20.2 Whole blood 7.80E-01 -3.53E-03 -1.95E-02
Myocardial infarction BA41-BA50 Peripheral blood 1.06E-01 3.38E-01 5.65E-01
Myopathy 8C70.6 Muscle tissue 6.15E-03 -2.70E-01 -1.96E+00
Neonatal sepsis KA60 Whole blood 4.88E-10 3.20E-01 9.46E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 3.96E-04 -7.92E-01 -1.58E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 5.53E-01 -3.80E-02 -1.34E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 1.01E-01 -1.23E-01 -1.16E+00
Olive pollen allergy CA08.00 Peripheral blood 2.41E-01 1.65E-01 5.83E-01
Oral cancer 2B6E Oral tissue 9.88E-10 -5.21E-01 -1.69E+00
Osteoarthritis FA00-FA0Z Synovial tissue 7.56E-01 2.71E-02 8.28E-02
Osteoporosis FB83.1 Bone marrow 4.83E-02 1.76E-01 9.65E-01
Ovarian cancer 2C73 Ovarian tissue 8.13E-01 -1.26E-01 -3.65E-01
Pancreatic cancer 2C10 Pancreas 3.34E-02 -2.62E-01 -5.22E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 2.31E-01 -1.11E-01 -4.30E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 9.65E-01 -2.73E-02 -1.11E-01
Pituitary cancer 2D12 Pituitary tissue 8.86E-01 4.23E-02 1.34E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 5.20E-01 7.02E-03 2.29E-02
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 1.36E-01 -9.34E-02 -4.63E-01
Polycythemia vera 2A20.4 Whole blood 5.12E-01 3.62E-02 1.86E-01
Pompe disease 5C51.3 Biceps muscle 7.05E-01 -3.43E-03 -2.39E-02
Preterm birth KA21.4Z Myometrium 9.87E-02 -1.65E-01 -3.65E-01
Prostate cancer 2C82 Prostate 4.23E-04 -7.35E-01 -1.38E+00
Psoriasis EA90 Skin 4.00E-04 -4.19E-02 -1.10E-01
Rectal cancer 2B92 Rectal colon tissue 4.06E-01 1.36E-01 4.29E-01
Renal cancer 2C90-2C91 Kidney 6.04E-03 -9.72E-01 -1.13E+00
Retinoblastoma 2D02.2 Uvea 3.87E-05 -4.97E-01 -2.62E+00
Rheumatoid arthritis FA20 Synovial tissue 8.08E-01 -5.90E-02 -1.58E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 9.89E-02 7.02E-02 4.40E-01
Schizophrenia 6A20 Prefrontal cortex 6.29E-01 1.72E-02 5.23E-02
Schizophrenia 6A20 Superior temporal cortex 6.02E-01 6.10E-04 4.29E-03
Scleroderma 4A42.Z Whole blood 3.98E-04 -5.84E-01 -2.51E+00
Seizure 8A60-8A6Z Whole blood 9.96E-01 -5.58E-02 -1.73E-01
Sensitive skin EK0Z Skin 4.62E-01 1.02E-01 6.99E-01
Sepsis with septic shock 1G41 Whole blood 1.35E-11 2.72E-01 7.25E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 9.94E-01 9.53E-02 2.46E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 9.47E-01 5.91E-02 1.77E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 7.14E-01 3.50E-02 4.07E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 9.53E-01 -1.17E-01 -4.39E-01
Skin cancer 2C30-2C3Z Skin 1.80E-01 -4.16E-02 -9.00E-02
Thrombocythemia 3B63 Whole blood 6.06E-02 7.19E-02 4.24E-01
Thrombocytopenia 3B64 Whole blood 4.25E-01 5.69E-02 2.96E-01
Thyroid cancer 2D10 Thyroid 6.97E-02 2.24E-02 9.71E-02
Tibial muscular dystrophy 8C75 Muscle tissue 2.82E-03 -3.82E-01 -1.15E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 2.03E-02 -2.38E-01 -4.27E+00
Type 2 diabetes 5A11 Liver tissue 4.60E-01 5.34E-02 2.96E-01
Ureter cancer 2C92 Urothelium 9.66E-01 1.95E-02 6.78E-02
Uterine cancer 2C78 Endometrium tissue 1.84E-02 -7.09E-02 -2.57E-01
Vitiligo ED63.0 Skin 5.41E-01 3.25E-02 1.72E-01
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⏷ Show the Full List of Expression Under 107 Diseases

References

1 SLC22A13 catalyses unidirectional efflux of aspartate and glutamate at the basolateral membrane of type A intercalated cells in the renal collecting duct. Biochem J. 2014 Jan 15;457(2):243-51.