Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DT4NW1F)

DTP Name Mitochondrial iron transporter 2 (SLC25A28)
Gene Name SLC25A28
UniProt ID
Q96A46 (MFRN2_HUMAN)
VARIDT ID
DTD0189
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms Mitochondrial RNA-splicing protein 3/4 homolog; MRS3/4; hMRS3/4; Solute carrier family 25 member 28; SLC25A28; MFRN2; NPD016; Mitoferrin-2
DTP Family Mitochondrial Carrier (MC) Family ;
Tissue Specificity Ubiquitous. Expressed in placenta, lung,kidney, pancreas, liver, brain, skeletal muscle and heart.
Sequence
MELEGRGAGGVAGGPAAGPGRSPGESALLDGWLQRGVGRGAGGGEAGACRPPVRQDPDSG
PDYEALPAGATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWR
IIRTEGLWRPMRGLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGGNSHIANGAAGCVA
TLLHDAAMNPAEVVKQRMQMYNSPYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQA
IHFMTYEFLQEHFNPQRRYNPSSHVLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSH
ITGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQEEW
RAGK
Function
This mitochondrial transporter mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme.
Endogenous Substrate(s) Iron
TCDB ID
2.A.29.5.8
Gene ID
81894
Reactome Pathway
Mitochondrial iron-sulfur cluster biogenesis (R-HSA-1362409 )

Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 1.09E-02 2.06E-01 3.97E-01
Adrenocortical carcinoma 2D11.Z Kidney 1.10E-03 -2.62E-01 -7.73E-01
Alopecia ED70 Skin from scalp 1.07E-05 -2.42E-01 -9.56E-01
Alzheimer's disease 8A20 Entorhinal cortex 4.71E-03 1.22E-01 5.83E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 7.05E-01 1.58E-02 1.11E-01
Aortic stenosis BB70 Calcified aortic valve 4.22E-01 6.52E-01 8.99E-01
Apnea 7A40 Hyperplastic tonsil 2.96E-01 2.20E-01 3.16E-01
Arthropathy FA00-FA5Z Peripheral blood 7.17E-01 -1.23E-01 -6.73E-01
Asthma CA23 Nasal and bronchial airway 6.76E-06 4.58E-01 6.43E-01
Atopic dermatitis EA80 Skin 1.64E-02 6.51E-02 4.35E-01
Autism 6A02 Whole blood 6.94E-01 5.14E-02 1.20E-01
Autoimmune uveitis 9A96 Peripheral monocyte 8.46E-01 9.62E-02 3.74E-01
Autosomal dominant monocytopenia 4B04 Whole blood 9.92E-01 1.89E-01 2.36E-01
Bacterial infection of gingival 1C1H Gingival tissue 4.10E-01 1.06E-01 3.00E-01
Batten disease 5C56.1 Whole blood 8.84E-01 1.36E-01 7.12E-01
Behcet's disease 4A62 Peripheral blood 1.78E-01 -1.32E-01 -5.20E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 5.31E-01 4.63E-02 2.49E-01
Bladder cancer 2C94 Bladder tissue 1.88E-05 -8.39E-01 -3.39E+00
Breast cancer 2C60-2C6Z Breast tissue 1.68E-07 1.87E-01 3.44E-01
Cardioembolic stroke 8B11.20 Whole blood 4.65E-02 -1.43E-01 -6.39E-01
Cervical cancer 2C77 Cervical tissue 3.02E-02 4.59E-01 1.16E+00
Childhood onset rheumatic disease FA20.Z Peripheral blood 2.92E-01 -1.06E-01 -3.85E-01
Chronic hepatitis C 1E51.1 Whole blood 2.87E-01 -2.51E-01 -7.05E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 1.16E-01 -1.82E-01 -4.53E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 9.47E-02 -1.67E-01 -3.67E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 2.26E-01 1.02E-01 4.46E-01
Colon cancer 2B90 Colon tissue 7.92E-01 -9.02E-03 -2.82E-02
Coronary artery disease BA80-BA8Z Peripheral blood 3.33E-01 -7.43E-02 -3.16E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 7.22E-01 1.17E-01 2.30E-01
Endometriosis GA10 Endometrium tissue 6.01E-02 3.65E-02 2.19E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 8.96E-01 3.84E-03 2.07E-02
Familial hypercholesterolemia 5C80.00 Whole blood 1.59E-02 1.75E-01 6.67E-01
Gastric cancer 2B72 Gastric tissue 4.11E-03 -5.14E-01 -5.85E+00
Glioblastopma 2A00.00 Nervous tissue 3.03E-113 -7.27E-01 -1.82E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 3.44E-01 2.04E-01 5.90E-01
Head and neck cancer 2D42 Head and neck tissue 9.39E-12 3.78E-01 1.22E+00
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 3.54E-01 1.11E-01 3.18E-01
Huntington's disease 8A01.10 Whole blood 6.95E-02 8.66E-02 5.33E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 4.23E-01 3.19E-03 8.70E-03
Immunodeficiency 4A00-4A20 Peripheral blood 4.36E-03 -3.29E-01 -2.27E+00
Influenza 1.00E+30 Whole blood 3.27E-01 5.75E-01 1.48E+00
Interstitial cystitis GC00.3 Bladder tissue 2.58E-01 1.99E-01 1.15E+00
Intracranial aneurysm 8B01.0 Intracranial artery 2.03E-01 -1.28E-01 -4.65E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 1.41E-01 3.24E-02 1.68E-01
Ischemic stroke 8B11 Peripheral blood 8.89E-01 5.28E-02 2.51E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 9.23E-02 -3.49E-02 -1.32E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 5.23E-02 -5.47E-01 -1.15E+00
Lateral sclerosis 8B60.4 Skin 2.43E-02 -1.83E-01 -1.52E+00
Liver cancer 2C12.0 Liver tissue 2.77E-01 -8.70E-02 -2.27E-01
Liver failure DB99.7-DB99.8 Liver tissue 1.83E-04 -1.03E+00 -2.75E+00
Lung cancer 2C25 Lung tissue 3.87E-20 -2.46E-01 -7.99E-01
Lupus erythematosus 4A40 Whole blood 3.91E-03 4.17E-01 4.30E-01
Major depressive disorder 6A70-6A7Z Whole blood 4.10E-02 -8.97E-02 -4.57E-01
Major depressive disorder 6A70-6A7Z Hippocampus 9.04E-01 1.77E-02 1.23E-01
Melanoma 2C30 Skin 7.31E-03 -7.28E-01 -1.04E+00
Multiple myeloma 2A83.1 Bone marrow 2.97E-03 3.87E-01 1.38E+00
Multiple myeloma 2A83.1 Peripheral blood 3.67E-01 5.90E-02 2.32E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 4.41E-01 2.46E-01 6.67E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 3.30E-01 -1.86E-01 -4.71E-01
Myelofibrosis 2A20.2 Whole blood 1.02E-06 -1.96E-01 -9.23E-01
Myocardial infarction BA41-BA50 Peripheral blood 9.57E-01 2.26E-01 2.12E-01
Myopathy 8C70.6 Muscle tissue 6.00E-01 -3.88E-02 -1.04E-01
Neonatal sepsis KA60 Whole blood 3.02E-08 3.73E-01 8.32E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 7.81E-06 -8.06E-01 -2.65E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 3.11E-02 7.42E-01 3.11E+00
Obesity related type 2 diabetes 5A11 Omental adipose tissue 8.88E-01 -1.34E-01 -4.37E-01
Olive pollen allergy CA08.00 Peripheral blood 7.88E-01 6.93E-02 3.17E-01
Oral cancer 2B6E Oral tissue 5.10E-02 2.34E-01 5.17E-01
Osteoarthritis FA00-FA0Z Synovial tissue 2.81E-01 4.98E-01 6.18E-01
Osteoporosis FB83.1 Bone marrow 7.82E-01 -1.22E-01 -3.35E-01
Ovarian cancer 2C73 Ovarian tissue 5.28E-03 -3.43E-01 -1.35E+00
Pancreatic cancer 2C10 Pancreas 3.82E-01 2.77E-02 4.08E-02
Parkinson's disease 8A00.0 Substantia nigra tissue 4.11E-01 -1.51E-01 -8.42E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 8.95E-02 6.09E-02 2.67E-01
Pituitary cancer 2D12 Pituitary tissue 9.28E-01 4.13E-02 1.07E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 7.92E-01 1.52E-01 4.64E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 4.08E-01 3.86E-02 2.30E-01
Polycythemia vera 2A20.4 Whole blood 2.59E-05 -4.70E-02 -2.09E-01
Pompe disease 5C51.3 Biceps muscle 2.38E-01 -7.75E-02 -4.44E-01
Preterm birth KA21.4Z Myometrium 9.02E-01 8.41E-02 1.53E-01
Prostate cancer 2C82 Prostate 7.75E-02 8.70E-02 1.70E-01
Psoriasis EA90 Skin 2.28E-28 9.37E-01 2.02E+00
Rectal cancer 2B92 Rectal colon tissue 6.39E-02 3.45E-01 1.27E+00
Renal cancer 2C90-2C91 Kidney 6.00E-01 9.80E-02 2.41E-01
Retinoblastoma 2D02.2 Uvea 1.08E-06 -6.35E-01 -4.00E+00
Rheumatoid arthritis FA20 Synovial tissue 8.69E-05 1.45E+00 2.83E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 3.07E-02 -4.43E-02 -2.46E-01
Schizophrenia 6A20 Prefrontal cortex 7.47E-01 -2.42E-02 -8.26E-02
Schizophrenia 6A20 Superior temporal cortex 7.43E-01 0.00E+00 0.00E+00
Scleroderma 4A42.Z Whole blood 1.50E-01 -4.94E-02 -3.19E-01
Seizure 8A60-8A6Z Whole blood 3.54E-02 3.76E-01 8.82E-01
Sensitive skin EK0Z Skin 1.65E-01 2.04E-01 1.07E+00
Sepsis with septic shock 1G41 Whole blood 2.28E-30 5.17E-01 1.17E+00
Shwachman-Diamond syndrome 3A70.0 Bone marrow 8.72E-03 -3.29E-01 -1.56E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 6.98E-01 4.59E-02 1.40E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 7.25E-02 -2.68E-01 -1.89E+00
Sjogren's syndrome 4A43.2 Salivary gland tissue 5.53E-02 3.56E-01 2.01E+00
Skin cancer 2C30-2C3Z Skin 2.71E-01 4.58E-02 8.52E-02
Thrombocythemia 3B63 Whole blood 7.45E-05 -1.92E-01 -9.47E-01
Thrombocytopenia 3B64 Whole blood 1.75E-01 2.26E-01 3.32E-01
Thyroid cancer 2D10 Thyroid 1.12E-16 -3.83E-01 -1.23E+00
Tibial muscular dystrophy 8C75 Muscle tissue 9.35E-01 -1.78E-02 -4.21E-02
Tuberous sclerosis complex LD2D.2 Perituberal tissue 1.56E-01 -2.21E-01 -9.81E-01
Type 2 diabetes 5A11 Liver tissue 6.02E-01 3.27E-02 1.80E-01
Ureter cancer 2C92 Urothelium 2.97E-01 -7.27E-02 -4.01E-01
Uterine cancer 2C78 Endometrium tissue 4.14E-01 2.45E-02 5.29E-02
Vitiligo ED63.0 Skin 1.18E-03 2.26E-01 2.35E+00
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