Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DT5A9X2)

DTP Name	Sodium-dependent organic anion transporter (SLC10A6)
Gene Name	SLC10A6
UniProt ID	Q3KNW5 (SOAT_HUMAN)
VARIDT ID	DTD0078
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Synonyms	SLC10A6; SOAT; Solute carrier family 10 member 6
DTP Family	Bile Acid:Na(+) Symporter (BASS) Family ;
Tissue Specificity	Highly expressed in testis, placenta andpancreas. Moderately expressed in heart, lung and mammary gland.Weakly expressed in brain, colon, kidney, liver, ovary, prostate,small intestine, spleen and thymus.
Sequence	MRANCSSSSACPANSSEEELPVGLEVHGNLELVFTVVSTVMMGLLMFSLGCSVEIRKLWS HIRRPWGIAVGLLCQFGLMPFTAYLLAISFSLKPVQAIAVLIMGCCPGGTISNIFTFWVD GDMDLSISMTTCSTVAALGMMPLCIYLYTWSWSLQQNLTIPYQNIGITLVCLTIPVAFGV YVNYRWPKQSKIILKIGAVVGGVLLLVVAVAGVVLAKGSWNSDITLLTISFIFPLIGHVT GFLLALFTHQSWQRCRTISLETGAQNIQMCITMLQLSFTAEHLVQMLSFPLAYGLFQLID GFLIVAAYQTYKRRLKNKHGKKNSGCTEVCHTRKSTSSRETNAFLEVNEEGAITPGPPGP MDCHRALEPVGHITSCE
Function	This transporter transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner.
Endogenous Substrate(s)	Organic anions; Na+; Dehydroepiandrosterone sulfate; Estrone-3-sulfate; Pregnenolone sulfate; Sulfoconjugated taurolithocholate
TCDB ID	2.A.28.1.4
Gene ID	345274
Reactome Pathway	Transport of bile salts and organic acids, metal ions and amine compounds (R-HSA-425366 )