Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DT650XW)

DTP Name Natural resistance-associated macrophage protein 1 (SLC11A1)
Gene Name SLC11A1
UniProt ID
P49279 (NRAM1_HUMAN)
VARIDT ID
DTD0080
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms LSH; NRAMP; NRAMP 1; NRAMP1; SLC11A1; Solute carrier family 11 member 1
DTP Family Metal Ion (Mn(2+)-Iron) Transporter (NRAMP) Family ;
Tissue Specificity Macrophages; peripheral blood leukocytes,lung, spleen and liver.
Sequence
MTGDKGPQRLSGSSYGSISSPTSPTSPGPQQAPPRETYLSEKIPIPDTKPGTFSLRKLWA
FTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKD
LGEVCHLYYPKVPRTVLWLTIELAIVGSDMQEVIGTAIAFNLLSAGRIPLWGGVLITIVD
TFFFLFLDNYGLRKLEAFFGLLITIMALTFGYEYVVARPEQGALLRGLFLPSCPGCGHPE
LLQAVGIVGAIIMPHNIYLHSALVKSREIDRARRADIREANMYFLIEATIALSVSFIINL
FVMAVFGQAFYQKTNQAAFNICANSSLHDYAKIFPMNNATVAVDIYQGGVILGCLFGPAA
LYIWAIGLLAAGQSSTMTGTYAGQFVMEGFLRLRWSRFARVLLTRSCAILPTVLVAVFRD
LRDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPTLMQEFANGLLNKVVTSSIMVLVCAIN
LYFVVSYLPSLPHPAYFGLAALLAAAYLGLSTYLVWTCCLAHGATFLAHSSHHHFLYGLL
EEDQKGETSG
Function This transporter mediates the transport of divalent metal ion (iron and manganese) and involves in iron metabolism and host resistance to certain pathogens.
Endogenous Substrate(s) Mn2+; Fe2+; H+
TCDB ID
2.A.55.2.3
Gene ID
6556
KEGG Pathway
Lysosome (hsa04142 )
Reactome Pathway
Metal ion SLC transporters (R-HSA-425410 )
Neutrophil degranulation (R-HSA-6798695 )
Ion influx/efflux at host-pathogen interface (R-HSA-6803544 )
ROS and RNS production in phagocytes (R-HSA-1222556 )

Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 5.14E-31 -4.66E-01 -1.57E+00
Adrenocortical carcinoma 2D11.Z Kidney 1.28E-02 -2.20E-01 -6.20E-01
Alopecia ED70 Skin from scalp 1.40E-01 1.29E-01 4.57E-01
Alzheimer's disease 8A20 Entorhinal cortex 3.51E-06 2.02E-01 6.58E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 1.24E-01 3.56E-01 1.44E+00
Aortic stenosis BB70 Calcified aortic valve 6.25E-03 2.49E-01 1.08E+00
Apnea 7A40 Hyperplastic tonsil 2.97E-01 -9.67E-02 -5.93E-01
Arthropathy FA00-FA5Z Peripheral blood 5.93E-02 1.62E-01 7.40E-01
Asthma CA23 Nasal and bronchial airway 6.50E-01 -3.19E-02 -5.83E-02
Atopic dermatitis EA80 Skin 6.48E-01 3.29E-02 2.86E-01
Autism 6A02 Whole blood 1.20E-01 4.16E-02 2.02E-01
Autoimmune uveitis 9A96 Peripheral monocyte 7.52E-01 1.18E-01 4.55E-01
Autosomal dominant monocytopenia 4B04 Whole blood 1.88E-02 -4.94E-01 -9.87E-01
Bacterial infection of gingival 1C1H Gingival tissue 9.36E-09 2.02E-01 8.90E-01
Batten disease 5C56.1 Whole blood 9.83E-01 7.39E-02 2.42E-01
Behcet's disease 4A62 Peripheral blood 5.28E-01 -1.68E-02 -7.75E-02
Bipolar disorder 6A60-6A6Z Prefrontal cortex 2.96E-01 5.35E-03 3.56E-02
Bladder cancer 2C94 Bladder tissue 2.93E-03 5.93E-01 2.07E+00
Breast cancer 2C60-2C6Z Breast tissue 1.99E-20 1.97E-01 5.36E-01
Cardioembolic stroke 8B11.20 Whole blood 1.53E-06 7.49E-01 1.68E+00
Cervical cancer 2C77 Cervical tissue 8.13E-01 1.27E-02 5.97E-02
Childhood onset rheumatic disease FA20.Z Peripheral blood 9.72E-01 1.59E-02 1.93E-02
Chronic hepatitis C 1E51.1 Whole blood 7.45E-01 -1.90E-02 -3.23E-02
Chronic obstructive pulmonary disease CA22 Lung tissue 1.26E-01 1.28E-01 3.34E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 1.79E-04 2.28E-01 6.77E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 5.02E-01 3.29E-02 2.31E-01
Colon cancer 2B90 Colon tissue 1.92E-20 1.18E-01 5.64E-01
Coronary artery disease BA80-BA8Z Peripheral blood 3.51E-01 -3.68E-01 -1.26E+00
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 9.91E-01 2.74E-03 1.98E-02
Endometriosis GA10 Endometrium tissue 2.15E-01 3.06E-02 1.85E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 6.81E-02 -2.07E-01 -1.48E+00
Familial hypercholesterolemia 5C80.00 Whole blood 2.48E-01 1.48E-01 7.28E-01
Gastric cancer 2B72 Gastric tissue 2.07E-01 3.98E-01 1.47E+00
Glioblastopma 2A00.00 Nervous tissue 1.02E-18 2.44E-01 6.45E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 4.99E-01 7.21E-01 4.25E-01
Head and neck cancer 2D42 Head and neck tissue 6.01E-22 4.18E-01 1.68E+00
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 1.23E-01 1.55E-02 1.22E-01
Huntington's disease 8A01.10 Whole blood 1.27E-01 1.38E-01 4.33E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 1.61E-01 -4.23E-01 -8.75E-01
Immunodeficiency 4A00-4A20 Peripheral blood 2.48E-01 4.10E-02 3.85E-01
Influenza 1.00E+30 Whole blood 1.75E-01 4.04E-01 1.43E+00
Interstitial cystitis GC00.3 Bladder tissue 1.09E-03 4.34E-01 6.41E+00
Intracranial aneurysm 8B01.0 Intracranial artery 2.74E-02 5.85E-01 1.20E+00
Irritable bowel syndrome DD91.0 Rectal colon tissue 6.79E-01 -1.40E-02 -7.17E-02
Ischemic stroke 8B11 Peripheral blood 4.78E-01 7.13E-02 2.31E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 1.13E-02 9.64E-02 1.94E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 1.49E-04 3.64E-01 2.23E+00
Lateral sclerosis 8B60.4 Skin 3.66E-01 1.15E-01 7.08E-01
Liver cancer 2C12.0 Liver tissue 1.74E-04 -1.41E-01 -4.42E-01
Liver failure DB99.7-DB99.8 Liver tissue 1.74E-02 3.47E-01 1.53E+00
Lung cancer 2C25 Lung tissue 8.97E-40 -4.02E-01 -1.09E+00
Lupus erythematosus 4A40 Whole blood 2.45E-05 4.53E-01 4.97E-01
Major depressive disorder 6A70-6A7Z Whole blood 6.50E-02 1.49E-01 3.74E-01
Major depressive disorder 6A70-6A7Z Hippocampus 6.36E-01 4.75E-03 3.38E-02
Melanoma 2C30 Skin 5.00E-02 5.87E-01 9.62E-01
Multiple myeloma 2A83.1 Bone marrow 4.91E-02 -2.40E-01 -9.11E-01
Multiple myeloma 2A83.1 Peripheral blood 6.20E-01 -5.39E-02 -3.72E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 7.73E-02 1.53E-01 4.69E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 9.43E-01 3.27E-02 9.08E-02
Myelofibrosis 2A20.2 Whole blood 9.61E-01 1.19E-01 8.46E-01
Myocardial infarction BA41-BA50 Peripheral blood 2.04E-10 1.58E+00 1.40E+00
Myopathy 8C70.6 Muscle tissue 3.80E-01 -9.44E-02 -8.70E-01
Neonatal sepsis KA60 Whole blood 4.92E-27 6.40E-01 1.56E+00
Neuroectodermal tumour 2A00.11 Brain stem tissue 2.27E-04 -6.07E-01 -2.19E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 1.22E-01 4.55E-01 1.19E+00
Obesity related type 2 diabetes 5A11 Omental adipose tissue 6.65E-01 -5.56E-03 -6.04E-02
Olive pollen allergy CA08.00 Peripheral blood 6.10E-01 -3.52E-02 -5.06E-02
Oral cancer 2B6E Oral tissue 2.62E-03 2.07E-01 8.34E-01
Osteoarthritis FA00-FA0Z Synovial tissue 1.76E-01 1.66E-01 5.22E-01
Osteoporosis FB83.1 Bone marrow 1.39E-02 2.92E-01 2.93E+00
Ovarian cancer 2C73 Ovarian tissue 1.19E-01 3.11E-01 8.27E-01
Pancreatic cancer 2C10 Pancreas 4.58E-01 2.04E-01 4.03E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 4.98E-01 3.83E-01 7.21E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 7.67E-04 3.20E-01 1.20E+00
Pituitary cancer 2D12 Pituitary tissue 6.21E-01 -7.14E-02 -1.76E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 2.46E-01 -8.07E-02 -1.96E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 1.69E-02 9.36E-02 8.59E-01
Polycythemia vera 2A20.4 Whole blood 1.02E-06 1.75E-01 1.25E+00
Pompe disease 5C51.3 Biceps muscle 3.51E-02 -1.60E-01 -8.66E-01
Preterm birth KA21.4Z Myometrium 4.52E-02 -4.98E-01 -9.53E-01
Prostate cancer 2C82 Prostate 1.83E-06 -5.78E-01 -1.47E+00
Psoriasis EA90 Skin 9.04E-10 -4.88E-02 -1.32E-01
Rectal cancer 2B92 Rectal colon tissue 5.78E-03 9.37E-02 1.05E+00
Renal cancer 2C90-2C91 Kidney 8.60E-05 3.88E-01 1.96E+00
Retinoblastoma 2D02.2 Uvea 1.28E-02 -9.14E-02 -6.01E-01
Rheumatoid arthritis FA20 Synovial tissue 4.85E-01 3.44E-01 7.51E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 1.77E-01 2.79E-02 1.61E-01
Schizophrenia 6A20 Prefrontal cortex 6.50E-03 2.74E-01 3.86E-01
Schizophrenia 6A20 Superior temporal cortex 6.45E-02 1.26E-01 1.13E+00
Scleroderma 4A42.Z Whole blood 1.40E-01 2.10E-01 7.09E-01
Seizure 8A60-8A6Z Whole blood 6.34E-01 3.81E-02 1.08E-01
Sensitive skin EK0Z Skin 2.99E-01 -1.02E-02 -7.43E-02
Sepsis with septic shock 1G41 Whole blood 1.85E-88 6.79E-01 2.29E+00
Shwachman-Diamond syndrome 3A70.0 Bone marrow 3.83E-01 3.26E-02 3.12E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 5.28E-01 -1.66E-01 -8.37E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 4.53E-01 -2.89E-02 -1.71E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 2.53E-01 -3.45E-01 -1.41E+00
Skin cancer 2C30-2C3Z Skin 8.31E-01 -1.04E-02 -2.63E-02
Thrombocythemia 3B63 Whole blood 3.98E-01 9.98E-02 7.62E-01
Thrombocytopenia 3B64 Whole blood 1.29E-01 2.19E-01 3.55E-01
Thyroid cancer 2D10 Thyroid 4.33E-16 1.78E-01 8.14E-01
Tibial muscular dystrophy 8C75 Muscle tissue 4.26E-03 -1.43E-01 -8.21E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 1.31E-02 4.15E-01 5.16E+00
Type 2 diabetes 5A11 Liver tissue 2.95E-01 6.76E-03 3.16E-02
Ureter cancer 2C92 Urothelium 4.68E-01 -1.04E-02 -3.52E-02
Uterine cancer 2C78 Endometrium tissue 6.55E-03 9.03E-02 3.01E-01
Vitiligo ED63.0 Skin 7.09E-01 -2.13E-02 -9.94E-02
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