Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DT7648O)

DTP Name Mitochondrial uncoupling protein 3 (SLC25A9)
Gene Name SLC25A9
UniProt ID
P55916 (UCP3_HUMAN)
VARIDT ID
DTD0226
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms SLC25A9; Solute carrier family 25 member 9; UCP 3; UCP3
DTP Family Mitochondrial Carrier (MC) Family ;
Tissue Specificity Only in skeletal muscle and heart. Is moreexpressed in glycolytic than in oxidative skeletal muscles.
Sequence
MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRG
VLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRI
LAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWK
GTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDV
VKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKRA
LMKVQMLRESPF
Function
This transporter is mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. It may play a role in the modulation of tissue respiratory control. It participates in thermogenesis and energy balance.
Endogenous Substrate(s) H+; Cl-
TCDB ID
2.A.29.3.5
Gene ID
7352
Reactome Pathway
The proton buffering model (R-HSA-167827 )
The fatty acid cycling model (R-HSA-167826 )

Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 4.36E-03 7.69E-02 4.46E-01
Adrenocortical carcinoma 2D11.Z Kidney 2.48E-01 -8.35E-02 -2.33E-01
Alopecia ED70 Skin from scalp 3.16E-02 -1.11E-01 -5.19E-01
Alzheimer's disease 8A20 Entorhinal cortex 5.73E-01 8.91E-03 5.73E-02
Ankylosing spondylitis FA92.0 Pheripheral blood 4.90E-01 -8.84E-03 -3.02E-02
Aortic stenosis BB70 Calcified aortic valve 8.72E-01 1.17E-01 2.26E-01
Apnea 7A40 Hyperplastic tonsil 3.80E-01 -1.46E-01 -9.34E-01
Arthropathy FA00-FA5Z Peripheral blood 2.79E-01 -3.79E-02 -3.42E-01
Asthma CA23 Nasal and bronchial airway 1.12E-01 -8.32E-02 -2.69E-01
Atopic dermatitis EA80 Skin 9.95E-01 -3.02E-03 -4.52E-02
Autism 6A02 Whole blood 3.57E-02 -1.79E-01 -8.17E-01
Autoimmune uveitis 9A96 Peripheral monocyte 1.91E-05 -1.82E-01 -1.92E+00
Autosomal dominant monocytopenia 4B04 Whole blood 5.10E-01 4.32E-02 3.00E-01
Bacterial infection of gingival 1C1H Gingival tissue 1.87E-08 2.12E-01 9.70E-01
Batten disease 5C56.1 Whole blood 7.22E-01 6.77E-02 7.71E-01
Behcet's disease 4A62 Peripheral blood 9.99E-01 5.83E-02 5.00E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 5.39E-01 -7.88E-02 -5.56E-01
Bladder cancer 2C94 Bladder tissue 2.32E-03 4.04E-01 1.76E+00
Breast cancer 2C60-2C6Z Breast tissue 1.04E-01 -5.83E-02 -1.91E-01
Cardioembolic stroke 8B11.20 Whole blood 4.81E-03 -1.48E-01 -6.61E-01
Cervical cancer 2C77 Cervical tissue 2.85E-02 1.93E-01 7.14E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 1.00E-01 7.80E-02 3.31E-01
Chronic hepatitis C 1E51.1 Whole blood 5.62E-01 -2.05E-02 -1.58E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 9.23E-01 3.14E-02 1.60E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 1.45E-03 1.70E-01 5.98E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 1.37E-01 5.08E-02 1.34E+00
Colon cancer 2B90 Colon tissue 3.52E-11 -1.27E-01 -5.61E-01
Coronary artery disease BA80-BA8Z Peripheral blood 7.80E-01 -7.61E-02 -3.34E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 7.88E-01 8.16E-03 1.11E-01
Endometriosis GA10 Endometrium tissue 6.79E-01 -2.21E-02 -9.77E-02
Familial hypercholesterolemia 5C80.00 Peripheral blood 9.08E-01 -2.25E-02 -1.63E-01
Familial hypercholesterolemia 5C80.00 Whole blood 1.53E-01 -9.94E-02 -5.24E-01
Gastric cancer 2B72 Gastric tissue 2.61E-01 -4.13E-01 -1.45E+00
Glioblastopma 2A00.00 Nervous tissue 7.21E-57 -2.49E-01 -1.14E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 1.12E-01 -1.50E-01 -6.02E-01
Head and neck cancer 2D42 Head and neck tissue 2.61E-10 -2.14E-01 -8.90E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 4.47E-02 -1.27E-01 -6.35E-01
Huntington's disease 8A01.10 Whole blood 1.34E-01 5.44E-02 5.16E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 2.52E-01 -1.14E-01 -7.93E-01
Immunodeficiency 4A00-4A20 Peripheral blood 9.55E-01 1.80E-02 2.37E-01
Influenza 1.00E+30 Whole blood 9.36E-04 3.87E-01 4.11E+00
Interstitial cystitis GC00.3 Bladder tissue 3.68E-01 6.62E-02 1.17E+00
Intracranial aneurysm 8B01.0 Intracranial artery 9.44E-02 -1.48E-01 -3.61E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 6.11E-01 -1.67E-02 -8.58E-02
Ischemic stroke 8B11 Peripheral blood 5.66E-01 -3.70E-02 -2.94E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 8.29E-04 -4.69E-02 -1.44E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 5.94E-01 -1.30E-01 -6.03E-01
Lateral sclerosis 8B60.4 Skin 2.87E-01 -5.04E-02 -3.48E-01
Liver cancer 2C12.0 Liver tissue 2.53E-05 -1.75E-01 -6.90E-01
Liver failure DB99.7-DB99.8 Liver tissue 2.93E-01 1.06E-02 1.05E-01
Lung cancer 2C25 Lung tissue 5.04E-20 -1.11E-01 -6.02E-01
Lupus erythematosus 4A40 Whole blood 1.15E-04 -7.26E-02 -3.26E-01
Major depressive disorder 6A70-6A7Z Whole blood 4.14E-01 -4.47E-02 -1.83E-01
Major depressive disorder 6A70-6A7Z Hippocampus 5.78E-01 -4.20E-02 -2.97E-01
Melanoma 2C30 Skin 9.95E-01 3.51E-02 9.65E-02
Multiple myeloma 2A83.1 Bone marrow 5.26E-03 -2.10E-01 -1.43E+00
Multiple myeloma 2A83.1 Peripheral blood 6.21E-01 -2.62E-02 -1.29E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 2.58E-01 3.15E-01 1.11E+00
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 7.72E-01 5.06E-03 3.28E-02
Myelofibrosis 2A20.2 Whole blood 7.47E-02 -9.44E-02 -8.83E-01
Myocardial infarction BA41-BA50 Peripheral blood 6.51E-01 -5.71E-02 -1.23E-01
Myopathy 8C70.6 Muscle tissue 7.55E-03 -1.10E+00 -1.60E+00
Neonatal sepsis KA60 Whole blood 3.56E-01 -4.14E-02 -1.59E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 4.88E-03 -3.61E-01 -1.52E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 6.90E-01 -7.23E-02 -4.11E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 2.02E-01 8.35E-02 8.92E-01
Olive pollen allergy CA08.00 Peripheral blood 5.44E-04 2.52E-01 4.03E+00
Oral cancer 2B6E Oral tissue 1.04E-05 -5.12E-01 -7.47E-01
Osteoarthritis FA00-FA0Z Synovial tissue 8.98E-02 -6.87E-01 -7.16E-01
Osteoporosis FB83.1 Bone marrow 5.95E-01 1.36E-01 8.21E-01
Ovarian cancer 2C73 Ovarian tissue 8.34E-01 -3.57E-02 -1.24E-01
Pancreatic cancer 2C10 Pancreas 1.26E-02 -1.29E-01 -5.08E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 7.10E-01 -7.27E-02 -3.96E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 6.29E-02 -7.83E-02 -5.85E-01
Pituitary cancer 2D12 Pituitary tissue 5.88E-01 -3.52E-02 -1.43E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 4.25E-01 -1.40E-01 -6.38E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 1.56E-01 1.40E-01 3.30E-01
Polycythemia vera 2A20.4 Whole blood 6.87E-01 -3.68E-02 -3.76E-01
Pompe disease 5C51.3 Biceps muscle 1.30E-01 2.18E-01 1.57E-01
Preterm birth KA21.4Z Myometrium 8.37E-01 -1.64E-03 -1.68E-02
Prostate cancer 2C82 Prostate 9.93E-01 -9.80E-02 -2.24E-01
Psoriasis EA90 Skin 2.08E-01 9.87E-02 3.60E-01
Rectal cancer 2B92 Rectal colon tissue 6.22E-01 -4.81E-02 -4.80E-01
Renal cancer 2C90-2C91 Kidney 4.04E-03 -4.15E-01 -1.44E+00
Retinoblastoma 2D02.2 Uvea 4.56E-11 -7.35E-01 -5.61E+00
Rheumatoid arthritis FA20 Synovial tissue 3.18E-02 -7.88E-01 -9.43E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 4.67E-01 -1.18E-02 -1.06E-01
Schizophrenia 6A20 Prefrontal cortex 2.30E-01 4.01E-02 1.79E-01
Schizophrenia 6A20 Superior temporal cortex 5.66E-01 7.69E-02 5.36E-01
Scleroderma 4A42.Z Whole blood 5.55E-01 -2.29E-02 -1.77E-01
Seizure 8A60-8A6Z Whole blood 8.93E-01 3.24E-02 2.14E-01
Sensitive skin EK0Z Skin 8.13E-01 4.85E-02 2.84E-01
Sepsis with septic shock 1G41 Whole blood 2.42E-03 -1.63E-01 -5.99E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 7.21E-02 1.54E-01 1.20E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 4.61E-01 2.57E-02 1.12E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 7.42E-01 4.18E-02 8.97E-02
Sjogren's syndrome 4A43.2 Salivary gland tissue 3.73E-01 1.62E-01 1.13E+00
Skin cancer 2C30-2C3Z Skin 8.98E-04 -7.81E-02 -2.34E-01
Thrombocythemia 3B63 Whole blood 3.57E-01 -3.90E-02 -3.84E-01
Thrombocytopenia 3B64 Whole blood 9.71E-01 7.27E-02 1.70E-01
Thyroid cancer 2D10 Thyroid 4.90E-01 -5.09E-03 -2.98E-02
Tibial muscular dystrophy 8C75 Muscle tissue 2.05E-04 -1.02E+00 -2.06E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 4.35E-01 -2.76E-02 -1.71E-01
Type 2 diabetes 5A11 Liver tissue 1.35E-01 -1.45E-01 -1.62E+00
Ureter cancer 2C92 Urothelium 9.57E-01 -5.73E-02 -3.28E-01
Uterine cancer 2C78 Endometrium tissue 1.97E-02 6.64E-02 2.72E-01
Vitiligo ED63.0 Skin 2.55E-01 -2.93E-02 -1.90E-01
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⏷ Show the Full List of Expression Under 107 Diseases

The Drug Therapeutic Target (DTT) Role of This DTP

DTP DTT Name Mitochondrial uncoupling protein 3 (UCP3) DTT Info
DTP DTT Type Clinical trial
1 Clinical Trial Drug(s) Targeting This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
CL-316,243 DMXH1KC Obesity 5B81 Phase 2 [1]
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References

1 Anti-obesity and anti-diabetic effects of CL316,243, a highly specific beta 3-adrenoceptor agonist, in Otsuka Long-Evans Tokushima Fatty rats: induction of uncoupling protein and activation of glucose transporter 4 in white fat. Eur J Endocrinol. 1997 Apr;136(4):429-37.