Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DT7A9GF)

DTP Name Synaptic vesicle glycoprotein 2C (SLC22B3)
Gene Name SLC22B3
UniProt ID
Q496J9 (SV2C_HUMAN)
VARIDT ID
DTD0155
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms KIAA1054; SV2C; Synaptic vesicle glycoprotein SV2C
DTP Family Major Facilitator Superfamily (MFS)
Vesicular Neurotransmitter Transporter (VNT) Family (Related to the SP Family
Sequence
MEDSYKDRTSLMKGAKDIAREVKKQTVKKVNQAVDRAQDEYTQRSYSRFQDEEDDDDYYP
AGETYNGEANDDEGSSEATEGHDEDDEIYEGEYQGIPSMNQAKDSIVSVGQPKGDEYKDR
RELESERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAE
TDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQG
YGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAI
IPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMIL
KLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLT
FMRCFNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYAN
FTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDT
VFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVS
ALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVE
LYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLASTVLVCGGLVGLCLPD
TRTQVLM
Function This transporter positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.
TCDB ID
2.A.1.22.6
Gene ID
22987
KEGG Pathway
ECM-receptor interaction (hsa04512 )
Reactome Pathway
Toxicity of botulinum toxin type A (botA) (R-HSA-5250968 )
Toxicity of botulinum toxin type F (botF) (R-HSA-5250981 )
Toxicity of botulinum toxin type D (botD) (R-HSA-5250955 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
1 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [1]
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Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 4.28E-04 4.90E-02 3.93E-01
Adrenocortical carcinoma 2D11.Z Kidney 2.89E-02 -4.62E-02 -1.01E-01
Alopecia ED70 Skin from scalp 1.59E-05 -2.48E-01 -9.32E-01
Alzheimer's disease 8A20 Entorhinal cortex 9.35E-01 -5.10E-02 -6.99E-02
Ankylosing spondylitis FA92.0 Pheripheral blood 6.66E-01 1.68E-02 2.48E-01
Aortic stenosis BB70 Calcified aortic valve 8.34E-01 5.45E-02 8.42E-02
Apnea 7A40 Hyperplastic tonsil 6.20E-01 -1.33E-03 -8.01E-03
Arthropathy FA00-FA5Z Peripheral blood 8.66E-01 -1.26E-02 -9.94E-02
Asthma CA23 Nasal and bronchial airway 9.81E-04 1.50E-01 3.61E-01
Atopic dermatitis EA80 Skin 6.32E-01 7.84E-03 6.85E-02
Autism 6A02 Whole blood 6.74E-01 -4.39E-02 -4.62E-01
Autoimmune uveitis 9A96 Peripheral monocyte 3.12E-01 8.94E-02 8.50E-01
Autosomal dominant monocytopenia 4B04 Whole blood 1.31E-01 -7.01E-02 -5.95E-01
Bacterial infection of gingival 1C1H Gingival tissue 5.74E-01 6.14E-03 4.69E-02
Batten disease 5C56.1 Whole blood 6.22E-01 -2.41E-02 -2.89E-01
Behcet's disease 4A62 Peripheral blood 2.67E-01 1.02E-01 6.90E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 2.38E-01 -1.87E-01 -5.93E-01
Bladder cancer 2C94 Bladder tissue 4.46E-01 3.19E-01 6.02E-01
Breast cancer 2C60-2C6Z Breast tissue 9.94E-23 -1.57E-01 -7.62E-01
Cardioembolic stroke 8B11.20 Whole blood 4.04E-03 1.87E-01 9.61E-01
Cervical cancer 2C77 Cervical tissue 3.31E-01 -3.49E-02 -1.72E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 7.35E-01 3.10E-02 2.07E-01
Chronic hepatitis C 1E51.1 Whole blood 7.79E-02 1.14E-01 8.92E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 1.33E-01 7.77E-03 5.89E-02
Chronic obstructive pulmonary disease CA22 Small airway epithelium 2.91E-01 -2.24E-02 -2.30E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 7.12E-02 1.45E-01 1.53E+00
Colon cancer 2B90 Colon tissue 5.71E-02 -8.64E-02 -5.20E-01
Coronary artery disease BA80-BA8Z Peripheral blood 7.32E-01 3.77E-02 8.40E-02
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 2.47E-01 2.28E-02 2.42E-01
Endometriosis GA10 Endometrium tissue 4.07E-01 -5.78E-02 -1.50E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 9.26E-01 2.76E-02 3.76E-01
Familial hypercholesterolemia 5C80.00 Whole blood 7.79E-02 -2.29E-02 -1.66E-01
Gastric cancer 2B72 Gastric tissue 2.54E-07 -8.27E-01 -3.18E+01
Glioblastopma 2A00.00 Nervous tissue 2.87E-71 -1.14E+00 -1.42E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 5.36E-01 4.75E-02 1.43E-01
Head and neck cancer 2D42 Head and neck tissue 2.03E-03 -3.67E-02 -2.87E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 1.69E-01 -1.70E-01 -1.85E-01
Huntington's disease 8A01.10 Whole blood 6.47E-01 -2.61E-03 -1.73E-02
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 3.68E-01 -7.02E-02 -8.25E-01
Immunodeficiency 4A00-4A20 Peripheral blood 9.05E-02 8.69E-02 9.84E-01
Influenza 1.00E+30 Whole blood 9.56E-03 2.37E-01 9.50E+00
Interstitial cystitis GC00.3 Bladder tissue 1.00E+00 -1.32E-02 -1.20E-01
Intracranial aneurysm 8B01.0 Intracranial artery 3.25E-01 -9.09E-02 -5.22E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 9.54E-01 -2.34E-02 -7.99E-02
Ischemic stroke 8B11 Peripheral blood 7.84E-01 -3.29E-03 -2.64E-02
Juvenile idiopathic arthritis FA24 Peripheral blood 2.53E-02 1.13E-01 4.08E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 2.58E-01 -1.02E-01 -2.23E-01
Lateral sclerosis 8B60.4 Skin 3.73E-01 2.49E-02 3.93E-01
Liver cancer 2C12.0 Liver tissue 2.34E-02 -9.43E-02 -6.41E-01
Liver failure DB99.7-DB99.8 Liver tissue 3.08E-01 -6.24E-02 -4.08E-01
Lung cancer 2C25 Lung tissue 1.96E-03 -1.07E-02 -7.52E-02
Lupus erythematosus 4A40 Whole blood 9.96E-02 -6.93E-02 -2.96E-01
Major depressive disorder 6A70-6A7Z Whole blood 2.64E-02 1.38E-01 4.19E-01
Major depressive disorder 6A70-6A7Z Hippocampus 2.39E-01 -1.18E-01 -3.74E-01
Melanoma 2C30 Skin 4.28E-02 -1.09E-01 -2.65E-01
Multiple myeloma 2A83.1 Bone marrow 5.77E-01 -9.21E-02 -4.71E-01
Multiple myeloma 2A83.1 Peripheral blood 2.39E-01 2.24E-02 2.25E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 3.25E-01 -2.97E-02 -1.26E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 3.28E-01 3.39E-02 2.98E-01
Myelofibrosis 2A20.2 Whole blood 2.26E-01 -2.05E-02 -1.57E-01
Myocardial infarction BA41-BA50 Peripheral blood 9.26E-01 -8.40E-02 -1.41E-01
Myopathy 8C70.6 Muscle tissue 2.43E-01 -4.44E-02 -3.35E-01
Neonatal sepsis KA60 Whole blood 2.49E-05 5.18E-02 3.41E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 1.13E-06 -2.09E+00 -3.88E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 9.69E-01 -3.06E-02 -2.83E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 5.63E-01 6.53E-02 5.29E-01
Olive pollen allergy CA08.00 Peripheral blood 5.88E-01 -2.16E-01 -7.65E-01
Oral cancer 2B6E Oral tissue 5.50E-04 -2.00E-01 -1.29E+00
Osteoarthritis FA00-FA0Z Synovial tissue 1.27E-01 -2.53E-01 -1.08E+00
Osteoporosis FB83.1 Bone marrow 4.48E-01 2.11E-02 2.30E-01
Ovarian cancer 2C73 Ovarian tissue 1.18E-01 -3.77E-01 -4.17E-01
Pancreatic cancer 2C10 Pancreas 5.37E-03 -2.88E-01 -9.28E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 3.46E-03 -1.29E+00 -1.75E+00
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 7.72E-01 -1.00E-02 -1.02E-01
Pituitary cancer 2D12 Pituitary tissue 5.31E-01 -2.33E-01 -4.77E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 7.98E-01 -1.56E-01 -3.07E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 2.55E-01 -3.59E-02 -2.91E-01
Polycythemia vera 2A20.4 Whole blood 7.83E-01 1.38E-02 9.66E-02
Pompe disease 5C51.3 Biceps muscle 6.24E-01 5.01E-02 4.12E-01
Preterm birth KA21.4Z Myometrium 1.29E-01 -1.85E-01 -1.34E+00
Prostate cancer 2C82 Prostate 1.63E-01 2.63E-01 4.71E-01
Psoriasis EA90 Skin 3.19E-14 -2.25E-01 -8.80E-01
Rectal cancer 2B92 Rectal colon tissue 7.82E-01 -1.04E-02 -3.03E-02
Renal cancer 2C90-2C91 Kidney 5.91E-01 -1.40E-01 -8.46E-01
Retinoblastoma 2D02.2 Uvea 4.62E-08 -2.63E+00 -3.44E+00
Rheumatoid arthritis FA20 Synovial tissue 1.48E-02 -3.57E-01 -1.21E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 2.50E-01 -2.87E-02 -2.84E-01
Schizophrenia 6A20 Prefrontal cortex 1.42E-01 -1.05E-01 -1.37E-01
Schizophrenia 6A20 Superior temporal cortex 2.16E-01 -1.14E-01 -3.46E-01
Scleroderma 4A42.Z Whole blood 6.74E-01 2.22E-02 2.40E-01
Seizure 8A60-8A6Z Whole blood 4.78E-01 -3.23E-02 -2.49E-01
Sensitive skin EK0Z Skin 8.96E-01 5.15E-02 4.38E-01
Sepsis with septic shock 1G41 Whole blood 6.41E-08 7.72E-02 4.27E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 4.93E-01 4.37E-02 1.52E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 4.01E-01 8.71E-02 5.60E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 7.84E-02 1.69E-01 1.83E+00
Sjogren's syndrome 4A43.2 Salivary gland tissue 3.77E-01 -4.60E-02 -6.58E-01
Skin cancer 2C30-2C3Z Skin 3.54E-05 -1.68E-01 -6.63E-01
Thrombocythemia 3B63 Whole blood 4.44E-01 -5.01E-02 -3.80E-01
Thrombocytopenia 3B64 Whole blood 9.65E-01 -2.85E-02 -1.90E-01
Thyroid cancer 2D10 Thyroid 2.58E-02 -1.45E-02 -9.57E-02
Tibial muscular dystrophy 8C75 Muscle tissue 1.01E-01 -2.63E-02 -2.13E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 8.93E-01 2.36E-01 5.17E-01
Type 2 diabetes 5A11 Liver tissue 6.50E-01 -7.35E-03 -5.83E-02
Ureter cancer 2C92 Urothelium 7.01E-01 -3.66E-02 -2.58E-01
Uterine cancer 2C78 Endometrium tissue 4.11E-05 -1.73E-01 -4.00E-01
Vitiligo ED63.0 Skin 4.01E-01 5.80E-02 1.76E-01
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⏷ Show the Full List of Expression Under 107 Diseases

References

1 Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2253-E2262.