Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DT7LDG0)

• DTP Name: ATP-binding cassette sub-family A member 12 (ABCA12)
• Gene Name: ABCA12
• UniProt ID: Q86UK0 (ABCAC_HUMAN)
• VARIDT ID: DTD0038
• Synonyms: ABC12; ABCA12; ARCI4A; ARCI4B; ATP-binding cassette 12; ATP-binding cassette transporter 12; ICR2B; LI2
• DTP Family:
  ATP-Binding Cassette (ABC) Superfamily
  Cholesterol/Phospholipid/Retinal (CPR) Flippase Family (ABCA)
• Tissue Specificity: Mainly expressed in the stomach, placenta,testis and fetal brain.
• Sequence:
  MASLFHQLQILVWKNWLGVKRQPLWTLVLILWPVIIFIILAITRTKFPPTAKPTCYLAPR
  NLPSTGFFPFLQTLLCDTDSKCKDTPYGPQDLLRRKGIDDALFKDSEILRKSSNLDKDSS
  LSFQSTQVPERRHASLATVFPSPSSDLEIPGTYTFNGSQVLARILGLEKLLKQNSTSEDI
  RRELCDSYSGYIVDDAFSWTFLGRNVFNKFCLSNMTLLESSLQELNKQFSQLSSDPNNQK
  IVFQEIVRMLSFFSQVQEQKAVWQLLSSFPNVFQNDTSLSNLFDVLRKANSVLLVVQKVY
  PRFATNEGFRTLQKSVKHLLYTLDSPAQGDSDNITHVWNEDDGQTLSPSSLAAQLLILEN
  FEDALLNISANSPYIPYLACVRNVTDSLARGSPENLRLLQSTIRFKKSFLRNGSYEDYFP
  PVPEVLKSKLSQLRNLTELLCESETFSLIEKSCQLSDMSFGSLCEESEFDLQLLEAAELG
  TEIAASLLYHDNVISKKVRDLLTGDPSKINLNMDQFLEQALQMNYLENITQLIPIIEAML
  HVNNSADASEKPGQLLEMFKNVEELKEDLRRTTGMSNRTIDKLLAIPIPDNRAEIISQVF
  WLHSCDTNITTPKLEDAMKEFCNLSLSERSRQSYLIGLTLLHYLNIYNFTYKVFFPRKDQ
  KPVEKMMELFIRLKEILNQMASGTHPLLDKMRSLKQMHLPRSVPLTQAMYRSNRMNTPQG
  SFSTISQALCSQGITTEYLTAMLPSSQRPKGNHTKDFLTYKLTKEQIASKYGIPINSTPF
  CFSLYKDIINMPAGPVIWAFLKPMLLGRILYAPYNPVTKAIMEKSNVTLRQLAELREKSQ
  EWMDKSPLFMNSFHLLNQAIPMLQNTLRNPFVQVFVKFSVGLDAVELLKQIDELDILRLK
  LENNIDIIDQLNTLSSLTVNISSCVLYDRIQAAKTIDEMEREAKRLYKSNELFGSVIFKL
  PSNRSWHRGYDSGNVFLPPVIKYTIRMSLKTAQTTRSLRTKIWAPGPHNSPSHNQIYGRA
  FIYLQDSIERAIIELQTGRNSQEIAVQVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVF
  IAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILKFGNILP
  KTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVENEL
  SYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILAD
  SFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQN
  TNPSASPEYMFSSNIEPEPKDLTVGVALHGVTKIYGSKVAVDNLNLNFYEGHITSLLGPN
  GAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLL
  LYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVV
  ILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGS
  PFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVL
  PPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLEHLT
  QKKIGNSNANGISTPDDLSVSSSNFTDRDDKILTRGERLDGFGLLLKKIMAILIKRFHHT
  RRNWKGLIAQVILPIVFVTTAMGLGTLRNSSNSYPEIQISPSLYGTSEQTAFYANYHPST
  EALVSAMWDFPGIDNMCLNTSDLQCLNKDSLEKWNTSGEPITNFGVCSCSENVQECPKFN
  YSPPHRRTYSSQVIYNLTGQRVENYLISTANEFVQKRYGGWSFGLPLTKDLRFDITGVPA
  NRTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSKYDAARHGIIMYSHPYPGVQDQEQAT
  ISSLIDILVALSILMGYSVTTASFVTYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMV
  FYLVPVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFI
  TYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELS
  QQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRLFFR
  KFNSSHVRETIDEDEDVRAERLRVESGAAEFDLVQLYCLTKTYQLIHKKIIAVNNISIGI
  PAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSLVGYCPQED
  ALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLST
  ALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLA
  IMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFPKTYLKDQHLSM
  LEYHVPVTAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQKSYETADTSSQ
  GSTISVDSQDDQMES
• Function: This transporter is probable transporter involved in lipid homeostasis.
• Endogenous Substrate(s): Lipids; Ceramide
• TCDB ID: 3.A.1.211.13
• Gene ID: 26154
• KEGG Pathway: ABC transporters (hsa02010)
• Reactome Pathway:
  Defective ABCA12 causes ARCI4B (R-HSA-5682294)
  ABC transporters in lipid homeostasis (R-HSA-1369062)

Molecular Interaction Atlas (MIA) of This DTP

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cholesterol	DMR3J6S	Discovery agent	N.A.	Investigative	[1]

Molecular Expression Atlas (MEA) of This DTP

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	2.47E-06	4.93E-02	4.55E-01
Adrenocortical carcinoma	2D11.Z	Kidney	2.92E-01	-1.37E-02	-1.29E-01
Alopecia	ED70	Skin from scalp	2.95E-01	1.52E-01	3.28E-01
Alzheimer's disease	8A20	Entorhinal cortex	3.99E-01	-1.21E-02	-9.61E-02
Ankylosing spondylitis	FA92.0	Pheripheral blood	1.96E-01	9.44E-02	8.85E-01
Aortic stenosis	BB70	Calcified aortic valve	2.99E-01	1.04E-01	2.78E-01
Apnea	7A40	Hyperplastic tonsil	3.99E-02	-1.10E+00	-7.20E-01
Arthropathy	FA00-FA5Z	Peripheral blood	2.27E-01	8.59E-02	6.66E-01
Asthma	CA23	Nasal and bronchial airway	4.24E-07	8.01E-01	6.67E-01
Atopic dermatitis	EA80	Skin	1.33E-07	-1.72E+00	-5.59E+00
Autism	6A02	Whole blood	6.47E-01	-1.64E-02	-1.28E-01
Autoimmune uveitis	9A96	Peripheral monocyte	1.40E-02	-1.33E-01	-9.74E-01
Autosomal dominant monocytopenia	4B04	Whole blood	6.73E-01	7.99E-02	6.49E-01
Bacterial infection of gingival	1C1H	Gingival tissue	7.99E-18	-1.17E+00	-1.48E+00
Batten disease	5C56.1	Whole blood	6.54E-01	3.04E-02	1.84E-01
Behcet's disease	4A62	Peripheral blood	5.87E-01	1.47E-02	8.24E-02
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	6.77E-01	-2.68E-02	-2.02E-01
Bladder cancer	2C94	Bladder tissue	6.20E-10	5.36E-01	3.26E+00
Breast cancer	2C60-2C6Z	Breast tissue	9.96E-36	5.89E-01	6.02E-01
Cardioembolic stroke	8B11.20	Whole blood	6.55E-01	3.69E-02	2.16E-01
Cervical cancer	2C77	Cervical tissue	4.80E-01	3.44E-01	3.20E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	1.03E-01	6.99E-02	6.31E-01
Chronic hepatitis C	1E51.1	Whole blood	6.89E-01	-1.29E-02	-8.88E-02
Chronic obstructive pulmonary disease	CA22	Lung tissue	9.46E-01	3.34E-02	2.37E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	1.82E-02	4.07E-02	6.16E-02
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	1.48E-01	3.92E-02	4.49E-01
Colon cancer	2B90	Colon tissue	8.70E-25	8.04E-02	4.28E-01
Coronary artery disease	BA80-BA8Z	Peripheral blood	2.53E-01	-1.12E-01	-1.09E+00
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	1.21E-01	-1.06E-01	-1.09E+00
Endometriosis	GA10	Endometrium tissue	7.88E-02	-2.85E-02	-1.03E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	1.04E-01	1.23E-01	1.39E+00
Familial hypercholesterolemia	5C80.00	Whole blood	7.54E-01	-1.12E-02	-7.81E-02
Gastric cancer	2B72	Gastric tissue	5.61E-03	1.81E-01	1.19E+00
Glioblastopma	2A00.00	Nervous tissue	9.37E-02	-1.15E-02	-3.52E-02
Glioma	2A00.0Y-2A00.0Z	White matter tissue	5.70E-02	-2.82E-01	-1.11E+00
Head and neck cancer	2D42	Head and neck tissue	2.57E-20	2.04E+00	1.95E+00
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	9.22E-01	4.23E-03	2.72E-02
Huntington's disease	8A01.10	Whole blood	6.02E-01	-2.25E-03	-1.91E-02
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	2.47E-02	1.44E-01	2.36E+00
Immunodeficiency	4A00-4A20	Peripheral blood	6.34E-01	-8.91E-03	-6.49E-02
Influenza	1.00E+30	Whole blood	5.33E-01	1.11E-01	6.36E-01
Interstitial cystitis	GC00.3	Bladder tissue	2.92E-04	1.57E-01	3.81E+00
Intracranial aneurysm	8B01.0	Intracranial artery	3.17E-01	1.28E-01	5.74E-01
Irritable bowel syndrome	DD91.0	Rectal colon tissue	8.09E-02	3.39E-02	1.36E-01
Ischemic stroke	8B11	Peripheral blood	3.65E-01	-1.87E-02	-1.72E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	2.54E-01	-2.08E-02	-1.01E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	7.30E-01	7.17E-02	4.32E-01
Lateral sclerosis	8B60.4	Skin	9.90E-01	-3.60E-02	-3.85E-01
Liver cancer	2C12.0	Liver tissue	9.49E-01	-2.91E-02	-1.68E-01
Liver failure	DB99.7-DB99.8	Liver tissue	3.73E-01	-1.10E-02	-1.23E-01
Lung cancer	2C25	Lung tissue	6.93E-134	6.77E-01	4.46E+00
Lupus erythematosus	4A40	Whole blood	1.81E-01	1.21E-02	6.14E-02
Major depressive disorder	6A70-6A7Z	Whole blood	2.14E-01	-3.20E-03	-1.59E-02
Major depressive disorder	6A70-6A7Z	Hippocampus	9.14E-01	-3.73E-02	-2.99E-01
Melanoma	2C30	Skin	6.79E-02	-1.68E+00	-8.21E-01
Multiple myeloma	2A83.1	Bone marrow	1.36E-01	-1.26E-01	-7.75E-01
Multiple myeloma	2A83.1	Peripheral blood	2.10E-01	2.33E-02	2.95E-01
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	8.63E-01	6.06E-02	1.42E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	1.37E-01	3.21E-02	2.85E-01
Myelofibrosis	2A20.2	Whole blood	6.03E-01	5.26E-02	4.78E-01
Myocardial infarction	BA41-BA50	Peripheral blood	8.59E-01	-2.55E-02	-6.53E-02
Myopathy	8C70.6	Muscle tissue	3.36E-01	-5.57E-04	-2.52E-03
Neonatal sepsis	KA60	Whole blood	2.65E-01	3.48E-02	2.33E-01
Neuroectodermal tumour	2A00.11	Brain stem tissue	7.33E-01	-5.29E-02	-3.37E-01
Non-alcoholic fatty liver disease	DB92	Liver tissue	2.27E-01	-5.75E-02	-5.47E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	8.39E-01	2.02E-02	2.59E-01
Olive pollen allergy	CA08.00	Peripheral blood	2.97E-01	-1.29E-01	-9.49E-01
Oral cancer	2B6E	Oral tissue	1.33E-05	1.86E+00	1.38E+00
Osteoarthritis	FA00-FA0Z	Synovial tissue	3.71E-01	-4.16E-02	-2.51E-01
Osteoporosis	FB83.1	Bone marrow	5.40E-01	1.54E-02	1.86E-01
Ovarian cancer	2C73	Ovarian tissue	6.45E-02	-6.93E-02	-2.78E-01
Pancreatic cancer	2C10	Pancreas	3.96E-05	2.14E-01	8.47E-01
Parkinson's disease	8A00.0	Substantia nigra tissue	4.21E-01	-5.58E-03	-3.38E-02
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	1.16E-01	-6.69E-02	-6.65E-01
Pituitary cancer	2D12	Pituitary tissue	8.57E-01	-7.32E-02	-3.07E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	9.04E-01	-1.87E-01	-6.75E-01
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	3.84E-01	-4.62E-04	-3.69E-03
Polycythemia vera	2A20.4	Whole blood	6.82E-01	2.38E-02	2.28E-01
Pompe disease	5C51.3	Biceps muscle	4.30E-02	-1.07E-01	-5.79E-01
Preterm birth	KA21.4Z	Myometrium	4.68E-01	1.86E-02	1.78E-01
Prostate cancer	2C82	Prostate	1.51E-05	3.58E-01	1.13E+00
Psoriasis	EA90	Skin	1.58E-38	2.02E+00	2.86E+00
Rectal cancer	2B92	Rectal colon tissue	1.08E-02	3.20E-02	2.61E-01
Renal cancer	2C90-2C91	Kidney	3.10E-06	2.19E-01	8.80E-01
Retinoblastoma	2D02.2	Uvea	1.13E-01	-1.04E-01	-6.94E-01
Rheumatoid arthritis	FA20	Synovial tissue	6.13E-01	-6.22E-02	-3.05E-01
Rhinovirus infection	CA42.1	Nasal epithelium tissue	8.79E-01	-1.33E-02	-2.18E-02
Schizophrenia	6A20	Prefrontal cortex	2.67E-01	1.71E-02	1.27E-01
Schizophrenia	6A20	Superior temporal cortex	8.93E-01	2.79E-02	3.25E-01
Scleroderma	4A42.Z	Whole blood	3.70E-02	6.22E-02	5.59E-01
Seizure	8A60-8A6Z	Whole blood	7.42E-01	2.20E-03	1.96E-02
Sensitive skin	EK0Z	Skin	6.12E-01	-9.93E-02	-2.49E-01
Sepsis with septic shock	1G41	Whole blood	2.50E-02	0.00E+00	0.00E+00
Shwachman-Diamond syndrome	3A70.0	Bone marrow	1.99E-01	-8.33E-02	-6.46E-01
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	2.26E-01	6.68E-02	3.70E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	1.46E-01	3.12E-02	7.59E-01
Sjogren's syndrome	4A43.2	Salivary gland tissue	5.45E-01	1.48E-02	1.09E-01
Skin cancer	2C30-2C3Z	Skin	1.53E-80	-3.80E+00	-4.89E+00
Thrombocythemia	3B63	Whole blood	4.28E-01	7.98E-02	7.26E-01
Thrombocytopenia	3B64	Whole blood	8.60E-01	3.38E-02	2.64E-01
Thyroid cancer	2D10	Thyroid	4.01E-04	4.97E-02	2.90E-01
Tibial muscular dystrophy	8C75	Muscle tissue	1.32E-04	-1.22E-01	-1.01E+00
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	2.20E-01	5.44E-02	7.02E-01
Type 2 diabetes	5A11	Liver tissue	7.30E-01	2.29E-02	1.44E-01
Ureter cancer	2C92	Urothelium	2.17E-01	5.21E-02	3.40E-01
Uterine cancer	2C78	Endometrium tissue	2.36E-06	1.39E-01	1.78E-01
Vitiligo	ED63.0	Skin	4.80E-01	-8.08E-03	-2.85E-02

References

• [1] ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis. Cell Metab. 2013 Aug 6;18(2):225-38.