| DTP Name |
Inward rectifier K(+) channel Kir3.2 (KCNJ6)
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| Gene Name |
KCNJ6
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| UniProt ID |
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| VARIDT ID |
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| 3D Structure |
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| Synonyms |
BIR1; GIRK-2; GIRK2; G protein-activated inward rectifier potassium channel 2; KATP-2; KATP2; KCNJ6; KCNJ7; KIR3.2; KPLBS; Potassium channel, inwardly rectifying subfamily J member 6; hiGIRK2 |
| DTP Family |
Inward Rectifier K(+) Channel (IRK-C) Family
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| Tissue Specificity |
Most abundant in cerebellum, and to a lesserdegree in islets and exocrine pancreas.
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| Sequence |
MAKLTESMTNVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKD
GKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGD
MDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSI
VNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAK
LIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKE
ELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYET
STPSLSAKELAELASRAELPLSWSVSSKLNQHAELETEEEEKNLEEQTERNGDVANLENE
SKV
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| Function |
This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
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| Endogenous Substrate(s) |
Potassium ions
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| TCDB ID |
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| Gene ID |
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| KEGG Pathway |
- Circadian entrainment (hsa04713 )
- Retrograde endocannabinoid signaling (hsa04723 )
- Cholinergic synapse (hsa04725 )
- Serotonergic synapse (hsa04726 )
- GABAergic synapse (hsa04727 )
- Dopaminergic synapse (hsa04728 )
- Estrogen signaling pathway (hsa04915 )
- Oxytocin signaling pathway (hsa04921 )
- GnRH secretion (hsa04929 )
- Morphine addiction (hsa05032 )
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| Reactome Pathway |
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (R-HSA-997272 )
- Activation of G protein gated Potassium channels (R-HSA-1296041 )
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