Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DT81RKJ)

DTP Name Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2)
Gene Name SLC35B2
UniProt ID
Q8TB61 (S35B2_HUMAN)
VARIDT ID
DTD0293
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms PAPS transporter 1; PAPST1; PSEC0149; Putative MAPK-activating protein PM15; Putative NF-kappa-B-activating protein 48; SLC35B2; SLL; Solute carrier family 35 member B2; UGTrel4
DTP Family Drug/Metabolite Transporter (DMT) Superfamily
UDP-Galactose:UMP Antiporter (UGA) Family
Tissue Specificity Highly expressed in the placenta, pancreas,mammary gland and skeletal muscle. Weakly or not expressed incolon, heart and prostate.
Sequence
MDARWWAVVVLAAFPSLGAGGETPEAPPESWTQLWFFRFVVNAAGYASFMVPGYLLVQYF
RRKNYLETGRGLCFPLVKACVFGNEPKASDEVPLAPRTEAAETTPMWQALKLLFCATGLQ
VSYLTWGVLQERVMTRSYGATATSPGERFTDSQFLVLMNRVLALIVAGLSCVLCKQPRHG
APMYRYSFASLSNVLSSWCQYEALKFVSFPTQVLAKASKVIPVMLMGKLVSRRSYEHWEY
LTATLISIGVSMFLLSSGPEPRSSPATTLSGLILLAGYIAFDSFTSNWQDALFAYKMSSV
QMMFGVNFFSCLFTVGSLLEQGALLEGTRFMGRHSEFAAHALLLSICSACGQLFIFYTIG
QFGAAVFTIIMTLRQAFAILLSCLLYGHTVTVVGGLGVAVVFAALLLRVYARGRLKQRGK
KAVPVESPVQKV
Function This transporter mediates the transport of adenosine 3'- phosphate 5'- phosphate sulfate (PAPS) from cytoplasm to Golgi apparatus.
Endogenous Substrate(s) Adenosine 3'-phosphate 5'-phosphosulfate; Adenosine 3'-phosphate 5'-phosphate
TCDB ID
2.A.7.11.3
Gene ID
347734
Reactome Pathway
Transport of nucleotide sugars (R-HSA-727802 )
Transport and synthesis of PAPS (R-HSA-174362 )