Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DT8HR5O)

DTP Name S-adenosylmethionine mitochondrial carrier protein (SLC25A26)
Gene Name SLC25A26
UniProt ID
Q70HW3 (SAMC_HUMAN)
VARIDT ID
DTD0187
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms COXPD28; Mitochondrial S-adenosylmethionine transporter; SAMC; SLC25A26; Solute carrier family 25 member 26
DTP Family Mitochondrial Carrier (MC) Family ;
Tissue Specificity Widely expressed. Highly expressed in testis,with moderate expression in brain, heart, kidney, lung, skeletalmuscle, pancreas, small intestine and liver, and low expression inspleen.
Sequence
MDRPGFVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFSKAGGFHGIYAGVPSAAIGS
FPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRAQVSA
STRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWSWRQDHVVDSW
QSAVCGAFAGGFAAAVTTPLDVAKTRITLAKAGSSTADGNVLSVLHGVWRSQGLAGLFAG
VFPRMAAISLGGFIFLGAYDRTHSLLLEVGRKSP
Function This transporter specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria and shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane.
Endogenous Substrate(s) S-adenosylmethionine
TCDB ID
2.A.29.18.3
Gene ID
115286
Reactome Pathway
Transport of inorganic cations/anions and amino acids/oligopeptides (R-HSA-425393 )

Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 7.67E-47 7.40E-01 2.35E+00
Adrenocortical carcinoma 2D11.Z Kidney 3.50E-01 -5.21E-02 -2.10E-01
Alopecia ED70 Skin from scalp 7.40E-01 2.19E-02 9.45E-02
Alzheimer's disease 8A20 Entorhinal cortex 1.71E-09 -2.73E-01 -7.85E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 8.97E-02 3.97E-01 1.43E+00
Aortic stenosis BB70 Calcified aortic valve 5.37E-01 -5.22E-01 -6.40E-01
Apnea 7A40 Hyperplastic tonsil 7.71E-01 -2.15E-01 -4.15E-01
Arthropathy FA00-FA5Z Peripheral blood 1.49E-01 -1.84E-01 -8.84E-01
Asthma CA23 Nasal and bronchial airway 1.67E-08 5.32E-01 6.32E-01
Atopic dermatitis EA80 Skin 4.92E-04 -1.21E-01 -8.92E-01
Autism 6A02 Whole blood 7.64E-01 3.65E-02 1.31E-01
Autoimmune uveitis 9A96 Peripheral monocyte 6.63E-01 3.27E-02 1.76E-01
Autosomal dominant monocytopenia 4B04 Whole blood 2.88E-01 4.45E-01 1.17E+00
Bacterial infection of gingival 1C1H Gingival tissue 5.29E-02 -5.02E-02 -2.06E-01
Batten disease 5C56.1 Whole blood 8.05E-01 5.00E-02 3.53E-01
Behcet's disease 4A62 Peripheral blood 5.27E-02 -1.71E-01 -1.61E+00
Bipolar disorder 6A60-6A6Z Prefrontal cortex 2.33E-01 -1.95E-02 -4.90E-02
Bladder cancer 2C94 Bladder tissue 2.02E-03 -3.72E-01 -1.92E+00
Breast cancer 2C60-2C6Z Breast tissue 8.22E-26 -3.82E-01 -7.39E-01
Cardioembolic stroke 8B11.20 Whole blood 8.13E-01 -2.63E-02 -1.01E-01
Cervical cancer 2C77 Cervical tissue 3.22E-05 -3.15E-01 -1.21E+00
Childhood onset rheumatic disease FA20.Z Peripheral blood 6.75E-01 2.07E-02 2.24E-02
Chronic hepatitis C 1E51.1 Whole blood 5.67E-01 1.12E-01 3.72E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 3.22E-01 -2.15E-02 -1.20E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 2.63E-01 -7.27E-02 -2.62E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 8.45E-01 -1.28E-01 -8.15E-01
Colon cancer 2B90 Colon tissue 7.83E-52 4.14E-01 1.62E+00
Coronary artery disease BA80-BA8Z Peripheral blood 9.28E-02 5.44E-01 1.13E+00
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 6.14E-01 -8.46E-02 -2.04E-01
Endometriosis GA10 Endometrium tissue 1.77E-01 -1.47E-01 -3.75E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 5.61E-01 -6.19E-02 -8.60E-01
Familial hypercholesterolemia 5C80.00 Whole blood 1.19E-01 2.56E-01 1.18E+00
Gastric cancer 2B72 Gastric tissue 2.27E-01 1.68E-01 8.52E-01
Glioblastopma 2A00.00 Nervous tissue 4.73E-64 -4.92E-01 -1.14E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 2.93E-01 -3.23E-01 -7.49E-01
Head and neck cancer 2D42 Head and neck tissue 3.01E-04 -1.98E-01 -6.41E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 6.53E-01 1.39E-02 3.36E-02
Huntington's disease 8A01.10 Whole blood 6.08E-02 -1.72E-01 -1.41E+00
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 1.42E-02 3.56E-01 2.63E+00
Immunodeficiency 4A00-4A20 Peripheral blood 4.75E-01 -1.60E-01 -1.07E+00
Influenza 1.00E+30 Whole blood 9.14E-02 -3.44E-01 -1.49E+00
Interstitial cystitis GC00.3 Bladder tissue 1.39E-03 -4.39E-01 -2.59E+00
Intracranial aneurysm 8B01.0 Intracranial artery 1.86E-01 -1.49E-01 -7.27E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 2.45E-01 3.73E-02 1.09E-01
Ischemic stroke 8B11 Peripheral blood 5.00E-01 1.46E-02 6.01E-02
Juvenile idiopathic arthritis FA24 Peripheral blood 1.09E-02 2.06E-02 5.72E-02
Lateral sclerosis 8B60.4 Cervical spinal cord 9.53E-01 2.88E-02 5.50E-02
Lateral sclerosis 8B60.4 Skin 8.75E-01 -2.04E-02 -1.62E-01
Liver cancer 2C12.0 Liver tissue 5.16E-07 -3.33E-01 -1.06E+00
Liver failure DB99.7-DB99.8 Liver tissue 1.88E-01 -2.41E-01 -6.37E-01
Lung cancer 2C25 Lung tissue 6.08E-01 -9.78E-03 -3.71E-02
Lupus erythematosus 4A40 Whole blood 2.04E-01 1.21E-01 1.37E-01
Major depressive disorder 6A70-6A7Z Whole blood 1.59E-01 -8.93E-02 -3.02E-01
Major depressive disorder 6A70-6A7Z Hippocampus 8.86E-01 9.03E-03 2.36E-02
Melanoma 2C30 Skin 5.28E-01 -5.51E-01 -7.91E-01
Multiple myeloma 2A83.1 Bone marrow 1.72E-06 1.22E+00 4.60E+00
Multiple myeloma 2A83.1 Peripheral blood 8.66E-01 -6.51E-02 -3.31E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 7.10E-01 -9.14E-02 -2.86E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 4.00E-01 -1.66E-01 -3.97E-01
Myelofibrosis 2A20.2 Whole blood 7.87E-01 2.02E-02 1.34E-01
Myocardial infarction BA41-BA50 Peripheral blood 6.32E-01 -6.63E-01 -5.38E-01
Myopathy 8C70.6 Muscle tissue 3.32E-01 -2.88E-01 -1.06E+00
Neonatal sepsis KA60 Whole blood 1.43E-12 -4.19E-01 -1.05E+00
Neuroectodermal tumour 2A00.11 Brain stem tissue 1.90E-02 3.90E-01 1.01E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 5.79E-01 -2.67E-02 -9.87E-02
Obesity related type 2 diabetes 5A11 Omental adipose tissue 6.47E-01 1.09E-01 4.38E-01
Olive pollen allergy CA08.00 Peripheral blood 5.25E-01 2.61E-02 4.24E-02
Oral cancer 2B6E Oral tissue 2.10E-03 -2.19E-01 -6.55E-01
Osteoarthritis FA00-FA0Z Synovial tissue 9.79E-01 1.08E-01 3.14E-01
Osteoporosis FB83.1 Bone marrow 6.16E-01 -1.17E-01 -1.65E+00
Ovarian cancer 2C73 Ovarian tissue 3.93E-01 -1.06E-01 -1.91E-01
Pancreatic cancer 2C10 Pancreas 7.98E-02 -1.66E-01 -4.04E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 4.34E-01 -1.30E-01 -2.80E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 1.64E-03 -2.25E-01 -1.46E+00
Pituitary cancer 2D12 Pituitary tissue 2.38E-05 6.65E-01 2.52E+00
Pituitary gonadotrope tumour 2D12 Pituitary tissue 2.82E-04 5.12E-01 1.75E+00
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 3.85E-01 2.22E-02 1.39E-01
Polycythemia vera 2A20.4 Whole blood 1.31E-05 -1.39E-01 -8.03E-01
Pompe disease 5C51.3 Biceps muscle 2.98E-01 -4.94E-02 -1.94E-01
Preterm birth KA21.4Z Myometrium 7.23E-01 4.18E-02 1.31E-01
Prostate cancer 2C82 Prostate 6.90E-03 1.17E+00 1.22E+00
Psoriasis EA90 Skin 1.73E-11 2.35E-01 5.95E-01
Rectal cancer 2B92 Rectal colon tissue 2.47E-02 1.79E-01 1.28E+00
Renal cancer 2C90-2C91 Kidney 2.40E-01 1.14E-01 4.63E-01
Retinoblastoma 2D02.2 Uvea 3.70E-01 -1.81E-01 -1.41E+00
Rheumatoid arthritis FA20 Synovial tissue 8.64E-01 2.85E-02 6.40E-02
Rhinovirus infection CA42.1 Nasal epithelium tissue 2.67E-01 -8.11E-02 -4.20E-01
Schizophrenia 6A20 Prefrontal cortex 2.34E-03 -1.46E-01 -3.68E-01
Schizophrenia 6A20 Superior temporal cortex 6.39E-01 2.96E-02 1.35E-01
Scleroderma 4A42.Z Whole blood 4.85E-01 4.20E-02 2.34E-01
Seizure 8A60-8A6Z Whole blood 4.21E-01 2.39E-01 8.48E-01
Sensitive skin EK0Z Skin 4.50E-02 -1.29E-01 -3.61E+00
Sepsis with septic shock 1G41 Whole blood 2.66E-37 -5.19E-01 -1.49E+00
Shwachman-Diamond syndrome 3A70.0 Bone marrow 5.39E-02 -3.08E-01 -1.99E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 1.91E-02 -4.31E-01 -7.50E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 5.23E-01 2.00E-01 7.39E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 5.28E-01 -5.56E-01 -1.28E+00
Skin cancer 2C30-2C3Z Skin 4.06E-01 -6.86E-02 -1.57E-01
Thrombocythemia 3B63 Whole blood 8.23E-02 3.18E-02 1.96E-01
Thrombocytopenia 3B64 Whole blood 9.79E-01 2.86E-01 5.39E-01
Thyroid cancer 2D10 Thyroid 1.17E-03 -1.05E-01 -3.80E-01
Tibial muscular dystrophy 8C75 Muscle tissue 2.54E-02 -2.79E-01 -8.41E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 3.19E-01 -1.53E-01 -3.87E-01
Type 2 diabetes 5A11 Liver tissue 5.69E-01 -3.13E-02 -1.40E-01
Ureter cancer 2C92 Urothelium 4.67E-01 7.10E-02 2.73E-01
Uterine cancer 2C78 Endometrium tissue 1.30E-01 -6.77E-02 -1.59E-01
Vitiligo ED63.0 Skin 3.34E-03 1.70E-01 1.32E+00
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