Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DT9J8DO)

• DTP Name: Sodium/hydrogen exchanger 10 (SLC9C1)
• Gene Name: SLC9C1
• UniProt ID: Q4G0N8 (SL9C1_HUMAN)
• VARIDT ID: DTD0497
• Synonyms: NHE; NHE-10; Na(+)/H(+) exchanger 10; SLC9A10; SLC9C1; Solute carrier family 9 member 10; Solute carrier family 9 member C1; Sperm-specific Na(+)/H(+) exchanger; sNHE; sperm-NHE
• DTP Family: Monovalent Cation:Proton Antiporter-1 (CPA1) family
• Sequence:
  MAGIFKEFFFSTEDLPEVILTLSLISSIGAFLNRHLEDFPIPVPVILFLLGCSFEVLSFT
  SSQVQRYANAIQWMSPDLFFRIFTPVVFFTTAFDMDTYMLQKLFWQILLISIPGFLVNYI
  LVLWHLASVNQLLLKPTQWLLFSAILVSSDPMLTAAAIRDLGLSRSLISLINGESLMTSV
  ISLITFTSIMDFDQRLQSKRNHTLAEEIVGGICSYIIASFLFGILSSKLIQFWMSTVFGD
  DVNHISLIFSILYLIFYICELVGMSGIFTLAIVGLLLNSTSFKAAIEETLLLEFWTFLSR
  IAFLMVFTFFGLLIPAHTYLYIEFVDIYYSLNIYLTLIVLRFLTLLLISPVLSRVGHEFS
  WRWIFIMVCSEMKGMPNINMALLLAYSDLYFGSDKEKSQILFHGVLVCLITLVVNRFILP
  VAVTILGLRDATSTKYKSVCCTFQHFQELTKSAASALKFDKDLANADWNMIEKAITLENP
  YMLNEEETTEHQKVKCPHCNKEIDEIFNTEAMELANRRLLSAQIASYQRQYRNEILSQSA
  VQVLVGAAESFGEKKGKCMSLDTIKNYSESQKTVTFARKLLLNWVYNTRKEKEGPSKYFF
  FRICHTIVFTEEFEHVGYLVILMNIFPFIISWISQLNVIYHSELKHTNYCFLTLYILEAL
  LKIAAMRKDFFSHAWNIFELAITLIGILHVILIEIDTIKYIFNETEVIVFIKVVQFFRIL
  RIFKLIAPKLLQIIDKRMSHQKTFWYGILKGYVQGEADIMTIIDQITSSKQIKQMLLKQV
  IRNMEHAIKELGYLEYDHPEIAVTVKTKEEINVMLNMATEILKAFGLKGIISKTEGAGIN
  KLIMAKKKEVLDSQSIIRPLTVEEVLYHIPWLDKNKDYINFIQEKAKVVTFDCGNDIFEE
  GDEPKGIYIIISGMVKLEKSKPGLGIDQMVESKEKDFPIIDTDYMLSGEIIGEINCLTNE
  PMKYSATCKTVVETCFIPKTHLYDAFEQCSPLIKQKMWLKLGLAITARKIREHLSYEDWN
  YNMQLKLSNIYVVDIPMSTKTDIYDENLIYVILIHGAVEDCLLRKTYRAPFLIPITCHQI
  QSIEDFTKVVIIQTPINMKTFRRNIRKFVPKHKSYLTPGLIGSVGTLEEGIQEERNVKED
  GAHSAATARSPQPCSLLGTKFNCKESPRINLRKVRKE
• Function: This transporter is involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Sperm-specific sodium/hydrogen exchanger gets involved in intracellular pH regulation of spermatozoa and Required for sperm motility and fertility. So the transporter is required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC).
• Endogenous Substrate(s): Na+; H+
• TCDB ID: 2.A.36.7.5
• Gene ID: 285335
• Reactome Pathway: Stimuli-sensing channels (R-HSA-2672351)