Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DT9SQ3L)

DTP Name Glucose transporter type 3, brain (SLC2A3)
Gene Name SLC2A3
UniProt ID
P11169 (GTR3_HUMAN)
VARIDT ID
DTD0258
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Synonyms GLUT-3; GLUT3; SLC2A3; Solute carrier family 2, facilitated glucose transporter member 3
DTP Family Major Facilitator Superfamily (MFS)
Sugar Porter (SP) Family
Tissue Specificity Highly expressed in brain. Expressed in manytissues.
Sequence
MGTQKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLT
SLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEML
ILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGS
EELWPLLLGFTILPAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQ
EMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAG
VQEPIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDNYN
GMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLF
PSAAHYLGAYVFIIFTGFLITFLAFTFFKVPETRGRTFEDITRAFEGQAHGADRSGKDGV
MEMNSIEPAKETTTNV
Function
This transporter facilitates glucose transport and mediates the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
Endogenous Substrate(s) Glucose
TCDB ID
2.A.1.1.91
Gene ID
6515
Reactome Pathway
Vitamin C (ascorbate) metabolism (R-HSA-196836 )
Neutrophil degranulation (R-HSA-6798695 )
MECP2 regulates neuronal receptors and channels (R-HSA-9022699 )
Cellular hexose transport (R-HSA-189200 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
1 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [1]
------------------------------------------------------------------------------------

Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 4.34E-11 -6.37E-01 -7.30E-01
Adrenocortical carcinoma 2D11.Z Kidney 1.57E-01 -2.21E-01 -1.97E-01
Alopecia ED70 Skin from scalp 1.08E-06 3.63E-01 1.05E+00
Alzheimer's disease 8A20 Entorhinal cortex 4.59E-05 -2.30E-01 -4.30E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 2.51E-01 -1.36E-01 -1.12E-01
Aortic stenosis BB70 Calcified aortic valve 9.49E-02 4.33E-01 6.81E-01
Apnea 7A40 Hyperplastic tonsil 7.01E-02 9.44E-01 2.22E+00
Arthropathy FA00-FA5Z Peripheral blood 7.52E-02 3.98E-01 1.45E+00
Asthma CA23 Nasal and bronchial airway 2.43E-02 1.84E-01 1.89E-01
Atopic dermatitis EA80 Skin 6.71E-03 4.29E-01 1.13E+00
Autism 6A02 Whole blood 3.75E-01 -2.06E-02 -2.99E-02
Autoimmune uveitis 9A96 Peripheral monocyte 2.97E-01 -1.15E+00 -8.81E-01
Autosomal dominant monocytopenia 4B04 Whole blood 2.18E-02 2.02E-01 6.55E-01
Bacterial infection of gingival 1C1H Gingival tissue 4.32E-15 9.75E-01 1.39E+00
Batten disease 5C56.1 Whole blood 9.73E-02 2.47E-01 1.95E+00
Behcet's disease 4A62 Peripheral blood 3.93E-01 -3.51E-01 -5.23E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 4.37E-01 -7.25E-02 -2.64E-01
Bladder cancer 2C94 Bladder tissue 2.69E-03 1.47E+00 1.98E+00
Breast cancer 2C60-2C6Z Breast tissue 1.33E-01 -1.99E-02 -2.32E-02
Cardioembolic stroke 8B11.20 Whole blood 9.64E-08 8.36E-01 1.94E+00
Cervical cancer 2C77 Cervical tissue 1.84E-03 1.06E+00 1.09E+00
Childhood onset rheumatic disease FA20.Z Peripheral blood 5.13E-01 9.85E-02 9.32E-02
Chronic hepatitis C 1E51.1 Whole blood 4.44E-01 1.91E-01 5.66E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 2.00E-01 1.06E-01 1.19E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 2.47E-03 4.40E-01 6.55E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 8.97E-01 1.25E-01 1.35E-01
Colon cancer 2B90 Colon tissue 8.55E-59 1.58E+00 2.18E+00
Coronary artery disease BA80-BA8Z Peripheral blood 8.90E-01 3.32E-01 3.98E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 4.71E-01 -1.47E-01 -5.05E-01
Endometriosis GA10 Endometrium tissue 1.25E-01 5.89E-01 4.73E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 5.36E-01 -1.34E-01 -6.85E-01
Familial hypercholesterolemia 5C80.00 Whole blood 3.76E-05 -5.90E-01 -1.44E+00
Gastric cancer 2B72 Gastric tissue 9.36E-01 1.12E+00 5.51E-01
Glioblastopma 2A00.00 Nervous tissue 4.18E-64 -9.43E-01 -1.43E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 9.92E-01 9.58E-02 1.42E-01
Head and neck cancer 2D42 Head and neck tissue 2.26E-24 1.82E+00 1.87E+00
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 6.39E-02 5.09E-01 7.16E-01
Huntington's disease 8A01.10 Whole blood 1.15E-01 3.42E-01 7.14E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 1.94E-02 -1.75E+00 -1.73E+00
Immunodeficiency 4A00-4A20 Peripheral blood 1.73E-03 3.96E-01 2.30E+00
Influenza 1.00E+30 Whole blood 2.27E-01 -1.04E+00 -1.42E+00
Interstitial cystitis GC00.3 Bladder tissue 2.67E-05 2.00E+00 4.91E+00
Intracranial aneurysm 8B01.0 Intracranial artery 8.27E-01 4.15E-01 2.41E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 1.13E-01 1.11E-01 2.37E-01
Ischemic stroke 8B11 Peripheral blood 1.15E-01 4.86E-02 5.52E-02
Juvenile idiopathic arthritis FA24 Peripheral blood 1.85E-11 4.90E-01 1.21E+00
Lateral sclerosis 8B60.4 Cervical spinal cord 3.99E-02 -5.23E-01 -1.24E+00
Lateral sclerosis 8B60.4 Skin 2.08E-02 -7.11E-01 -2.16E+00
Liver cancer 2C12.0 Liver tissue 3.46E-01 -2.63E-01 -3.05E-01
Liver failure DB99.7-DB99.8 Liver tissue 3.33E-01 4.23E-01 3.25E-01
Lung cancer 2C25 Lung tissue 1.71E-24 -5.54E-01 -7.66E-01
Lupus erythematosus 4A40 Whole blood 1.45E-04 4.66E-01 5.04E-01
Major depressive disorder 6A70-6A7Z Whole blood 9.88E-02 1.35E-01 3.78E-01
Major depressive disorder 6A70-6A7Z Hippocampus 6.23E-01 -6.29E-02 -2.37E-01
Melanoma 2C30 Skin 3.38E-04 8.62E-01 8.33E-01
Multiple myeloma 2A83.1 Bone marrow 5.28E-01 -3.47E-01 -4.52E-01
Multiple myeloma 2A83.1 Peripheral blood 3.47E-01 1.06E-01 1.83E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 4.09E-01 -9.92E-02 -1.50E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 2.89E-02 -4.08E-01 -3.54E-01
Myelofibrosis 2A20.2 Whole blood 9.82E-01 -2.03E-01 -6.04E-01
Myocardial infarction BA41-BA50 Peripheral blood 2.38E-08 8.96E-01 1.49E+00
Myopathy 8C70.6 Muscle tissue 2.80E-02 4.44E-01 9.58E-01
Neonatal sepsis KA60 Whole blood 2.34E-46 1.81E+00 2.65E+00
Neuroectodermal tumour 2A00.11 Brain stem tissue 5.40E-02 -8.63E-01 -1.32E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 7.16E-02 5.52E-01 1.03E+00
Obesity related type 2 diabetes 5A11 Omental adipose tissue 1.64E-01 2.54E-01 3.01E-01
Olive pollen allergy CA08.00 Peripheral blood 8.69E-01 -9.10E-02 -3.47E+00
Oral cancer 2B6E Oral tissue 1.11E-05 1.50E+00 1.38E+00
Osteoarthritis FA00-FA0Z Synovial tissue 9.78E-02 4.95E-01 3.87E-01
Osteoporosis FB83.1 Bone marrow 6.68E-03 1.04E+00 1.77E+00
Ovarian cancer 2C73 Ovarian tissue 1.92E-01 -4.05E-01 -2.49E-01
Pancreatic cancer 2C10 Pancreas 8.74E-01 2.87E-01 2.55E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 5.58E-02 2.17E-01 3.75E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 3.22E-03 6.49E-01 1.24E+00
Pituitary cancer 2D12 Pituitary tissue 1.34E-02 -1.01E+00 -1.22E+00
Pituitary gonadotrope tumour 2D12 Pituitary tissue 1.08E-02 -9.02E-01 -1.08E+00
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 6.61E-01 9.72E-02 3.70E-01
Polycythemia vera 2A20.4 Whole blood 1.43E-06 2.54E-01 8.38E-01
Pompe disease 5C51.3 Biceps muscle 1.25E-01 7.06E-01 1.01E+00
Preterm birth KA21.4Z Myometrium 1.70E-01 -5.11E-01 -7.81E-01
Prostate cancer 2C82 Prostate 3.58E-01 5.78E-01 3.56E-01
Psoriasis EA90 Skin 2.88E-01 5.56E-02 6.38E-02
Rectal cancer 2B92 Rectal colon tissue 2.98E-02 7.77E-01 1.23E+00
Renal cancer 2C90-2C91 Kidney 1.10E-03 1.45E+00 1.19E+00
Retinoblastoma 2D02.2 Uvea 1.09E-07 -1.60E+00 -3.26E+00
Rheumatoid arthritis FA20 Synovial tissue 1.93E-03 1.49E+00 1.54E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 1.28E-01 6.20E-02 7.41E-02
Schizophrenia 6A20 Prefrontal cortex 8.05E-01 5.42E-02 1.63E-01
Schizophrenia 6A20 Superior temporal cortex 2.77E-01 1.47E-01 5.78E-01
Scleroderma 4A42.Z Whole blood 9.90E-03 4.85E-01 1.77E+00
Seizure 8A60-8A6Z Whole blood 8.77E-01 1.27E-01 1.62E-01
Sensitive skin EK0Z Skin 3.15E-01 2.23E-01 6.40E-01
Sepsis with septic shock 1G41 Whole blood 6.24E-101 2.06E+00 3.28E+00
Shwachman-Diamond syndrome 3A70.0 Bone marrow 6.85E-01 -6.21E-02 -1.28E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 7.50E-01 1.13E-01 2.71E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 1.13E-02 1.85E+00 3.07E+00
Sjogren's syndrome 4A43.2 Salivary gland tissue 5.74E-01 -2.06E-01 -3.97E-01
Skin cancer 2C30-2C3Z Skin 2.83E-48 1.66E+00 2.02E+00
Thrombocythemia 3B63 Whole blood 6.53E-01 -1.02E-01 -3.05E-01
Thrombocytopenia 3B64 Whole blood 5.54E-01 -1.71E-01 -3.83E-01
Thyroid cancer 2D10 Thyroid 8.84E-12 7.54E-01 1.07E+00
Tibial muscular dystrophy 8C75 Muscle tissue 9.40E-03 8.75E-01 1.12E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 1.43E-02 -8.54E-01 -1.85E+00
Type 2 diabetes 5A11 Liver tissue 6.64E-01 5.53E-02 2.64E-01
Ureter cancer 2C92 Urothelium 7.53E-01 3.49E-01 2.48E-01
Uterine cancer 2C78 Endometrium tissue 5.40E-03 4.41E-01 3.59E-01
Vitiligo ED63.0 Skin 5.73E-01 -3.85E-03 -1.38E-02
------------------------------------------------------------------------------------
⏷ Show the Full List of Expression Under 107 Diseases

References

1 Ascorbic acid-dependent GLUT3 inhibition is a critical step for switching neuronal metabolism. J Cell Physiol. 2011 Dec;226(12):3286-94.