| DTP Name |
Sodium/potassium/calcium exchanger 5 (SLC24A5)
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| Gene Name |
SLC24A5
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| UniProt ID |
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| VARIDT ID |
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| 3D Structure |
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| Synonyms |
JSX; NCKX5; Na(+)/K(+)/Ca(2+)-exchange protein 5; OCA6; SHEP4; SLC24A5; Solute carrier family 24 member 5 |
| DTP Family |
Ca(2+):Cation Antiporter (CACA) Family
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| Sequence |
MQTKGGQTWARRALLLGILWATAHLPLSGTSLPQRLPRATGNSTQCVISPSSEFPEGFFT
RQERRDGGIIIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSA
PELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYT
ISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCCACLAKAME
RSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDPPSVFNMPE
ADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITG
ETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLCLGIPWFI
KTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCLLSYLGLAT
LSVLYELGIIGNNKIRGCGG
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| Function |
This transporter mediates the transport of cation and involves in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-Calcium exchanger in melanocytes. Probably transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+).
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| Endogenous Substrate(s) |
Ca2+; K+; Na+
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| TCDB ID |
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| Gene ID |
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| Reactome Pathway |
- Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) (R-HSA-5619036 )
- Sodium/Calcium exchangers (R-HSA-425561 )
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