Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTBCKVM)

DTP Name Neutral and basic amino acid transport protein rBAT (SLC3A1)
Gene Name SLC3A1
UniProt ID
Q07837 (SLC31_HUMAN)
VARIDT ID
DTD0351
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms ATR1; CSNU1; D2h; NBAT; RBAT; SLC3A1; Solute carrier family 3 member 1; b(0),+-type amino acid transport protein
DTP Family rBAT Transport Accessory Protein (rBAT) Family ;
Tissue Specificity Expressed in the brush border membrane in thekidney (at protein level). Predominantly expressed in the kidney,small intestine and pancreas. Weakly expressed in liver.
Sequence
MAEDKSKRDSIEMSMKGCQTNNGFVHNEDILEQTPDPGSSTDNLKHSTRGILGSQEPDFK
GVQPYAGMPKEVLFQFSGQARYRIPREILFWLTVASVLVLIAATIAIIALSPKCLDWWQE
GPMYQIYPRSFKDSNKDGNGDLKGIQDKLDYITALNIKTVWITSFYKSSLKDFRYGVEDF
REVDPIFGTMEDFENLVAAIHDKGLKLIIDFIPNHTSDKHIWFQLSRTRTGKYTDYYIWH
DCTHENGKTIPPNNWLSVYGNSSWHFDEVRNQCYFHQFMKEQPDLNFRNPDVQEEIKEIL
RFWLTKGVDGFSLDAVKFLLEAKHLRDEIQVNKTQIPDTVTQYSELYHDFTTTQVGMHDI
VRSFRQTMDQYSTEPGRYRFMGTEAYAESIDRTVMYYGLPFIQEADFPFNNYLSMLDTVS
GNSVYEVITSWMENMPEGKWPNWMIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYY
GEEIGMGNIVAANLNESYDINTLRSKSPMQWDNSSNAGFSEASNTWLPTNSDYHTVNVDV
QKTQPRSALKLYQDLSLLHANELLLNRGWFCHLRNDSHYVVYTRELDGIDRIFIVVLNFG
ESTLLNLHNMISGLPAKMRIRLSTNSADKGSKVDTSGIFLDKGEGLIFEHNTKNLLHRQT
AFRDRCFVSNRACYSSVLNILYTSC
Function
This transporter mediates the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). Involved in the high-affinity reabsorption of cystine in the kidney tubule.
Endogenous Substrate(s) Cystine
TCDB ID
8.A.9.1.2
Gene ID
6519
KEGG Pathway
Protein digestion and absorption (hsa04974 )
Reactome Pathway
Defective SLC3A1 causes cystinuria (CSNU) (R-HSA-5619113 )
Defective SLC7A9 causes cystinuria (CSNU) (R-HSA-5660883 )
Amino acid transport across the plasma membrane (R-HSA-352230 )

Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 9.11E-01 -7.02E-03 -5.35E-02
Adrenocortical carcinoma 2D11.Z Kidney 6.52E-01 -1.45E-02 -7.07E-02
Alopecia ED70 Skin from scalp 8.29E-01 -1.79E-02 -3.59E-02
Alzheimer's disease 8A20 Entorhinal cortex 5.00E-01 -9.76E-03 -7.13E-02
Ankylosing spondylitis FA92.0 Pheripheral blood 6.35E-02 9.88E-02 8.32E-01
Aortic stenosis BB70 Calcified aortic valve 8.39E-01 -1.02E-01 -1.33E-01
Apnea 7A40 Hyperplastic tonsil 3.68E-03 -2.36E-01 -1.78E+00
Arthropathy FA00-FA5Z Peripheral blood 9.31E-01 2.45E-02 2.30E-01
Asthma CA23 Nasal and bronchial airway 6.05E-01 -1.19E-01 -2.30E-01
Atopic dermatitis EA80 Skin 7.08E-02 -2.07E-02 -3.23E-01
Autism 6A02 Whole blood 3.09E-01 -2.95E-02 -1.58E-01
Autoimmune uveitis 9A96 Peripheral monocyte 1.81E-01 -1.31E-01 -1.48E+00
Autosomal dominant monocytopenia 4B04 Whole blood 7.44E-01 -6.38E-02 -3.00E-01
Bacterial infection of gingival 1C1H Gingival tissue 5.46E-01 1.64E-03 8.61E-03
Batten disease 5C56.1 Whole blood 2.87E-01 3.99E-02 3.29E-01
Behcet's disease 4A62 Peripheral blood 6.80E-01 1.39E-02 1.11E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 8.89E-01 1.94E-02 1.16E-01
Bladder cancer 2C94 Bladder tissue 7.35E-03 -3.89E-01 -1.59E+00
Breast cancer 2C60-2C6Z Breast tissue 4.49E-01 8.17E-03 4.63E-02
Cardioembolic stroke 8B11.20 Whole blood 2.80E-01 3.55E-02 7.58E-02
Cervical cancer 2C77 Cervical tissue 3.98E-02 -9.18E-02 -3.14E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 4.28E-01 -2.61E-02 -1.41E-01
Chronic hepatitis C 1E51.1 Whole blood 4.48E-01 -1.50E-01 -7.17E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 1.28E-01 1.11E-01 5.22E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 9.59E-01 2.15E-03 1.39E-02
Chronic rhinosinusitis CA0A Sinus mucosa tissue 3.16E-01 -2.47E-02 -1.66E-01
Colon cancer 2B90 Colon tissue 4.77E-01 -1.21E-04 -5.29E-04
Coronary artery disease BA80-BA8Z Peripheral blood 2.77E-01 -2.54E-02 -4.96E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 1.74E-01 -1.47E-01 -5.38E-01
Endometriosis GA10 Endometrium tissue 8.56E-02 -2.81E-02 -1.26E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 1.75E-01 7.82E-02 5.39E-01
Familial hypercholesterolemia 5C80.00 Whole blood 1.18E-01 -1.42E-01 -6.39E-01
Gastric cancer 2B72 Gastric tissue 6.57E-01 -1.11E-01 -7.54E-01
Glioblastopma 2A00.00 Nervous tissue 1.89E-01 1.41E-02 6.46E-02
Glioma 2A00.0Y-2A00.0Z White matter tissue 1.81E-01 3.77E-01 4.20E-01
Head and neck cancer 2D42 Head and neck tissue 8.15E-02 -2.45E-02 -1.59E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 6.35E-02 -8.86E-02 -4.07E-01
Huntington's disease 8A01.10 Whole blood 5.85E-01 -5.84E-02 -9.51E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 5.30E-01 4.55E-04 4.10E-03
Immunodeficiency 4A00-4A20 Peripheral blood 3.47E-01 -3.42E-02 -3.96E-01
Influenza 1.00E+30 Whole blood 1.13E-01 2.49E-01 1.90E+00
Interstitial cystitis GC00.3 Bladder tissue 3.99E-01 -2.47E-02 -1.49E-01
Intracranial aneurysm 8B01.0 Intracranial artery 7.29E-02 9.10E-02 5.19E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 5.17E-01 5.18E-02 1.25E-01
Ischemic stroke 8B11 Peripheral blood 6.19E-01 -1.39E-02 -7.17E-02
Juvenile idiopathic arthritis FA24 Peripheral blood 7.06E-02 1.13E-01 1.36E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 9.65E-01 -3.04E-02 -1.37E-01
Lateral sclerosis 8B60.4 Skin 4.24E-01 1.08E-01 6.04E-01
Liver cancer 2C12.0 Liver tissue 1.17E-04 -2.04E-01 -7.23E-01
Liver failure DB99.7-DB99.8 Liver tissue 2.64E-02 9.67E-02 6.26E-01
Lung cancer 2C25 Lung tissue 6.37E-04 -5.74E-02 -3.34E-01
Lupus erythematosus 4A40 Whole blood 1.14E-01 -1.12E-02 -2.20E-02
Major depressive disorder 6A70-6A7Z Whole blood 2.50E-01 -1.18E-01 -2.16E-01
Major depressive disorder 6A70-6A7Z Hippocampus 5.27E-01 2.46E-02 1.53E-01
Melanoma 2C30 Skin 1.20E-02 -2.17E-01 -3.53E-01
Multiple myeloma 2A83.1 Bone marrow 2.81E-04 1.42E-01 1.75E+00
Multiple myeloma 2A83.1 Peripheral blood 6.14E-01 -1.50E-02 -1.36E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 3.46E-01 2.76E-01 4.81E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 2.14E-05 1.40E-01 1.03E+00
Myelofibrosis 2A20.2 Whole blood 3.75E-02 -2.05E-02 -1.52E-01
Myocardial infarction BA41-BA50 Peripheral blood 4.25E-02 -1.48E-01 -1.67E-01
Myopathy 8C70.6 Muscle tissue 8.10E-01 1.36E-02 1.15E-01
Neonatal sepsis KA60 Whole blood 4.37E-01 1.38E-02 6.77E-02
Neuroectodermal tumour 2A00.11 Brain stem tissue 9.54E-02 -4.12E-02 -1.65E-01
Non-alcoholic fatty liver disease DB92 Liver tissue 5.07E-01 -8.07E-02 -4.90E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 4.09E-01 -2.39E-03 -3.58E-02
Olive pollen allergy CA08.00 Peripheral blood 2.11E-01 9.05E-02 6.64E-01
Oral cancer 2B6E Oral tissue 2.67E-01 -5.91E-02 -3.59E-01
Osteoarthritis FA00-FA0Z Synovial tissue 9.99E-01 -3.05E-02 -1.26E-01
Osteoporosis FB83.1 Bone marrow 7.28E-01 -1.05E-02 -4.97E-02
Ovarian cancer 2C73 Ovarian tissue 1.06E-01 -1.07E-01 -9.88E-01
Pancreatic cancer 2C10 Pancreas 1.31E-02 -5.38E-01 -1.14E+00
Parkinson's disease 8A00.0 Substantia nigra tissue 2.81E-01 -3.14E-02 -1.89E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 1.20E-01 8.79E-02 5.98E-01
Pituitary cancer 2D12 Pituitary tissue 1.08E-01 9.94E-02 1.02E+00
Pituitary gonadotrope tumour 2D12 Pituitary tissue 3.69E-01 -9.84E-02 -8.62E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 9.07E-01 4.67E-02 7.95E-01
Polycythemia vera 2A20.4 Whole blood 1.63E-01 4.12E-03 2.59E-02
Pompe disease 5C51.3 Biceps muscle 9.31E-01 -8.24E-02 -1.45E-01
Preterm birth KA21.4Z Myometrium 9.12E-01 -1.50E-02 -8.83E-02
Prostate cancer 2C82 Prostate 1.42E-04 5.37E-01 1.21E+00
Psoriasis EA90 Skin 3.58E-01 -2.90E-02 -1.15E-01
Rectal cancer 2B92 Rectal colon tissue 3.84E-02 -3.03E-01 -1.16E+00
Renal cancer 2C90-2C91 Kidney 8.82E-01 -1.43E-01 -1.92E-01
Retinoblastoma 2D02.2 Uvea 4.17E-01 -7.12E-02 -5.92E-01
Rheumatoid arthritis FA20 Synovial tissue 1.87E-02 -2.89E-01 -1.16E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 6.80E-01 4.06E-03 3.54E-02
Schizophrenia 6A20 Prefrontal cortex 2.85E-02 5.03E-02 3.32E-01
Schizophrenia 6A20 Superior temporal cortex 7.79E-01 -5.56E-02 -3.24E-01
Scleroderma 4A42.Z Whole blood 2.38E-02 -2.73E-01 -1.20E+00
Seizure 8A60-8A6Z Whole blood 2.63E-01 -3.16E-02 -1.49E-01
Sensitive skin EK0Z Skin 6.30E-01 0.00E+00 0.00E+00
Sepsis with septic shock 1G41 Whole blood 6.65E-01 8.70E-03 3.80E-02
Shwachman-Diamond syndrome 3A70.0 Bone marrow 5.51E-01 -5.51E-02 -1.97E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 1.23E-01 4.63E-02 3.93E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 6.83E-01 3.94E-02 4.44E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 1.10E-01 7.12E-02 1.94E+00
Skin cancer 2C30-2C3Z Skin 7.37E-02 -5.39E-02 -1.42E-01
Thrombocythemia 3B63 Whole blood 7.11E-01 4.31E-04 3.06E-03
Thrombocytopenia 3B64 Whole blood 8.51E-01 1.50E-01 1.95E-01
Thyroid cancer 2D10 Thyroid 1.08E-01 5.41E-02 2.46E-01
Tibial muscular dystrophy 8C75 Muscle tissue 7.04E-01 5.45E-02 8.36E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 3.30E-01 -1.34E-01 -1.84E+00
Type 2 diabetes 5A11 Liver tissue 7.42E-01 -4.69E-02 -3.06E-01
Ureter cancer 2C92 Urothelium 7.01E-01 -1.29E-01 -9.15E-01
Uterine cancer 2C78 Endometrium tissue 7.49E-01 1.10E-02 5.23E-02
Vitiligo ED63.0 Skin 6.52E-02 1.93E-01 4.27E-01
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