Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTBS49U)

DTP Name Proton-coupled amino acid transporter 4 (SLC36A4)
Gene Name SLC36A4
UniProt ID
Q6YBV0 (S36A4_HUMAN)
VARIDT ID
DTD0321
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms PAT4; Proton/amino acid transporter 4; SLC36A4; Solute carrier family 36 member 4
DTP Family Amino Acid/Auxin Permease (AAAP) Family ;
Sequence
MEAAATPAAAGAARREELDMDVMRPLINEQNFDGTSDEEHEQELLPVQKHYQLDDQEGIS
FVQTLMHLLKGNIGTGLLGLPLAIKNAGIVLGPISLVFIGIISVHCMHILVRCSHFLCLR
FKKSTLGYSDTVSFAMEVSPWSCLQKQAAWGRSVVDFFLVITQLGFCSVYIVFLAENVKQ
VHEGFLESKVFISNSTNSSNPCERRSVDLRIYMLCFLPFIILLVFIRELKNLFVLSFLAN
VSMAVSLVIIYQYVVRNMPDPHNLPIVAGWKKYPLFFGTAVFAFEGIGVVLPLENQMKES
KRFPQALNIGMGIVTTLYVTLATLGYMCFHDEIKGSITLNLPQDVWLYQSVKILYSFGIF
VTYSIQFYVPAEIIIPGITSKFHTKWKQICEFGIRSFLVSITCAGAILIPRLDIVISFVG
AVSSSTLALILPPLVEILTFSKEHYNIWMVLKNISIAFTGVVGFLLGTYITVEEIIYPTP
KVVAGTPQSPFLNLNSTCLTSGLK
Function This sodium-independent electroneutral transporter mediates the transport of tryptophan, proline and alanine. Inhibited by sarcosine.
Endogenous Substrate(s) H+
TCDB ID
2.A.18.8.5
Gene ID
120103
KEGG Pathway
Protein digestion and absorption (hsa04974 )
Reactome Pathway
Tryptophan catabolism (R-HSA-71240 )
Amino acid transport across the plasma membrane (R-HSA-352230 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
2 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-Proline DMKSTWR Malnutrition 5B50-5B71 Approved [1]
L-Tryptophan DMIBH7M Depression 6A70-6A7Z Approved [1]
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Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 1.22E-09 -3.21E-01 -6.90E-01
Adrenocortical carcinoma 2D11.Z Kidney 4.40E-01 -5.01E-02 -1.94E-01
Alopecia ED70 Skin from scalp 1.77E-01 -1.53E-01 -5.12E-01
Alzheimer's disease 8A20 Entorhinal cortex 5.84E-02 4.62E-02 2.04E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 4.00E-01 -6.45E-02 -3.59E-01
Aortic stenosis BB70 Calcified aortic valve 9.28E-01 -1.58E-01 -6.48E-01
Apnea 7A40 Hyperplastic tonsil 1.24E-01 1.32E-01 5.81E-01
Arthropathy FA00-FA5Z Peripheral blood 6.03E-01 -5.32E-02 -2.39E-01
Asthma CA23 Nasal and bronchial airway 6.79E-07 3.38E-01 6.16E-01
Atopic dermatitis EA80 Skin 9.58E-03 -1.07E-01 -5.97E-01
Autism 6A02 Whole blood 7.02E-01 3.03E-02 1.25E-01
Autoimmune uveitis 9A96 Peripheral monocyte 2.21E-01 1.93E-01 4.61E-01
Autosomal dominant monocytopenia 4B04 Whole blood 1.33E-01 5.45E-01 9.92E-01
Bacterial infection of gingival 1C1H Gingival tissue 6.16E-01 1.09E-02 3.77E-02
Batten disease 5C56.1 Whole blood 5.77E-01 -1.10E-01 -5.50E-01
Behcet's disease 4A62 Peripheral blood 9.18E-01 -9.41E-03 -2.76E-02
Bipolar disorder 6A60-6A6Z Prefrontal cortex 3.49E-01 8.18E-02 3.62E-01
Bladder cancer 2C94 Bladder tissue 6.44E-01 1.38E-01 3.53E-01
Breast cancer 2C60-2C6Z Breast tissue 3.50E-01 1.63E-02 3.47E-02
Cardioembolic stroke 8B11.20 Whole blood 2.00E-03 3.92E-01 1.04E+00
Cervical cancer 2C77 Cervical tissue 4.80E-07 5.21E-01 1.71E+00
Childhood onset rheumatic disease FA20.Z Peripheral blood 3.92E-01 3.66E-02 8.72E-02
Chronic hepatitis C 1E51.1 Whole blood 5.46E-01 1.02E-01 3.11E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 3.57E-01 7.03E-02 2.67E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 7.77E-04 1.82E-01 5.50E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 4.18E-02 1.52E-01 1.06E+00
Colon cancer 2B90 Colon tissue 9.47E-06 8.97E-02 2.93E-01
Coronary artery disease BA80-BA8Z Peripheral blood 3.46E-01 -3.80E-01 -8.23E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 8.20E-01 2.29E-02 8.66E-02
Endometriosis GA10 Endometrium tissue 4.79E-02 1.14E-01 1.56E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 7.81E-01 -8.91E-02 -4.11E-01
Familial hypercholesterolemia 5C80.00 Whole blood 7.15E-13 1.08E+00 1.90E+00
Gastric cancer 2B72 Gastric tissue 2.20E-02 3.37E-01 2.94E+00
Glioblastopma 2A00.00 Nervous tissue 1.07E-07 1.43E-01 3.17E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 2.10E-03 1.04E+00 1.41E+00
Head and neck cancer 2D42 Head and neck tissue 2.62E-02 7.02E-02 2.43E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 5.45E-01 5.50E-02 2.05E-01
Huntington's disease 8A01.10 Whole blood 2.80E-01 -1.03E-01 -4.26E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 1.51E-03 -5.82E-01 -2.56E+00
Immunodeficiency 4A00-4A20 Peripheral blood 5.71E-01 1.16E-02 5.59E-02
Influenza 1.00E+30 Whole blood 1.42E-01 -5.27E-01 -1.90E+00
Interstitial cystitis GC00.3 Bladder tissue 4.51E-04 5.02E-01 3.05E+00
Intracranial aneurysm 8B01.0 Intracranial artery 5.47E-01 5.04E-02 1.35E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 9.41E-01 1.35E-02 3.74E-02
Ischemic stroke 8B11 Peripheral blood 9.48E-01 7.55E-02 2.59E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 7.17E-01 -1.16E-02 -3.67E-02
Lateral sclerosis 8B60.4 Cervical spinal cord 2.55E-01 3.19E-01 6.47E-01
Lateral sclerosis 8B60.4 Skin 6.40E-01 -3.47E-02 -2.18E-01
Liver cancer 2C12.0 Liver tissue 6.93E-01 3.90E-02 8.02E-02
Liver failure DB99.7-DB99.8 Liver tissue 6.28E-02 -3.94E-01 -7.82E-01
Lung cancer 2C25 Lung tissue 1.66E-21 3.09E-01 8.67E-01
Lupus erythematosus 4A40 Whole blood 5.60E-02 2.19E-01 3.61E-01
Major depressive disorder 6A70-6A7Z Whole blood 7.23E-01 6.01E-02 1.16E-01
Major depressive disorder 6A70-6A7Z Hippocampus 2.79E-01 1.23E-01 5.60E-01
Melanoma 2C30 Skin 3.61E-01 -2.88E-01 -3.72E-01
Multiple myeloma 2A83.1 Bone marrow 2.64E-05 3.20E-01 2.67E+00
Multiple myeloma 2A83.1 Peripheral blood 9.61E-01 -1.53E-02 -5.75E-02
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 6.54E-02 -3.39E-01 -1.74E+00
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 1.99E-03 -2.88E-01 -7.48E-01
Myelofibrosis 2A20.2 Whole blood 2.02E-03 2.23E-01 8.00E-01
Myocardial infarction BA41-BA50 Peripheral blood 6.41E-01 -1.29E-01 -1.75E-01
Myopathy 8C70.6 Muscle tissue 7.41E-03 2.86E-01 1.85E+00
Neonatal sepsis KA60 Whole blood 8.10E-21 5.64E-01 1.66E+00
Neuroectodermal tumour 2A00.11 Brain stem tissue 1.45E-06 1.40E+00 3.23E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 8.43E-01 -2.52E-02 -1.05E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 1.11E-01 -2.00E-01 -4.41E-01
Olive pollen allergy CA08.00 Peripheral blood 2.34E-01 -5.94E-01 -1.61E+00
Oral cancer 2B6E Oral tissue 5.34E-05 5.10E-01 1.22E+00
Osteoarthritis FA00-FA0Z Synovial tissue 3.39E-01 3.59E-02 9.48E-02
Osteoporosis FB83.1 Bone marrow 3.90E-02 -4.47E-01 -1.01E+00
Ovarian cancer 2C73 Ovarian tissue 6.93E-01 -2.77E-01 -6.83E-01
Pancreatic cancer 2C10 Pancreas 9.99E-01 -8.63E-02 -2.14E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 9.99E-01 4.80E-02 1.14E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 1.03E-03 2.85E-01 1.07E+00
Pituitary cancer 2D12 Pituitary tissue 1.75E-01 -2.98E-01 -7.91E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 1.96E-01 -1.89E-01 -1.12E+00
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 4.77E-01 -8.80E-02 -5.33E-01
Polycythemia vera 2A20.4 Whole blood 6.92E-01 -8.01E-02 -2.97E-01
Pompe disease 5C51.3 Biceps muscle 2.14E-05 7.26E-01 3.45E+00
Preterm birth KA21.4Z Myometrium 4.85E-01 -2.86E-02 -9.88E-02
Prostate cancer 2C82 Prostate 8.08E-02 7.27E-01 8.21E-01
Psoriasis EA90 Skin 1.03E-23 4.23E-01 1.21E+00
Rectal cancer 2B92 Rectal colon tissue 2.92E-01 -9.72E-02 -5.03E-01
Renal cancer 2C90-2C91 Kidney 2.77E-03 4.19E-01 1.39E+00
Retinoblastoma 2D02.2 Uvea 8.47E-07 -9.92E-01 -2.78E+00
Rheumatoid arthritis FA20 Synovial tissue 9.66E-01 -2.15E-01 -5.22E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 3.70E-01 8.80E-03 5.03E-02
Schizophrenia 6A20 Prefrontal cortex 7.50E-01 -5.38E-02 -1.33E-01
Schizophrenia 6A20 Superior temporal cortex 6.16E-01 -8.81E-02 -3.93E-01
Scleroderma 4A42.Z Whole blood 2.69E-01 1.17E-02 1.45E-01
Seizure 8A60-8A6Z Whole blood 5.71E-02 3.53E-01 1.04E+00
Sensitive skin EK0Z Skin 2.07E-01 1.52E-01 2.14E+00
Sepsis with septic shock 1G41 Whole blood 3.90E-36 3.99E-01 1.25E+00
Shwachman-Diamond syndrome 3A70.0 Bone marrow 1.07E-01 -3.31E-01 -1.14E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 3.94E-03 -3.50E-01 -1.47E+00
Simpson golabi behmel syndrome LD2C Adipose tissue 9.94E-01 -2.97E-01 -3.79E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 1.48E-01 3.48E-01 1.09E+00
Skin cancer 2C30-2C3Z Skin 1.41E-08 2.47E-01 4.93E-01
Thrombocythemia 3B63 Whole blood 4.08E-01 -9.39E-02 -3.45E-01
Thrombocytopenia 3B64 Whole blood 3.09E-01 -2.62E-01 -3.48E-01
Thyroid cancer 2D10 Thyroid 6.93E-06 -2.22E-01 -8.34E-01
Tibial muscular dystrophy 8C75 Muscle tissue 1.35E-04 2.86E-01 1.55E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 3.50E-02 -5.43E-01 -3.90E+00
Type 2 diabetes 5A11 Liver tissue 4.08E-01 -3.69E-02 -1.71E-01
Ureter cancer 2C92 Urothelium 2.46E-01 4.74E-02 3.78E-01
Uterine cancer 2C78 Endometrium tissue 3.85E-21 5.14E-01 1.32E+00
Vitiligo ED63.0 Skin 1.17E-01 9.83E-02 4.19E-01
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⏷ Show the Full List of Expression Under 107 Diseases

References

1 SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes. J Biol Chem. 2011 Jan 28;286(4):2455-60.