Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTBZWL4)

DTP Name	Voltage-dependent L-type calcium channel beta-2 (CACNB2)
Gene Name	CACNB2
UniProt ID	Q08289 (CACB2_HUMAN)
VARIDT ID	DTD0535
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Synonyms	CAB2; CACNB2; CACNLB2; CAVB2; Calcium channel voltage-dependent subunit beta 2; Lambert-Eaton myasthenic syndrome antigen B; MYSB; Voltage-dependent L-type calcium channel subunit beta-2
DTP Family	Ca(2+) Channel Auxiliary Subunit Beta Types 1-4 (CCA-Beta) Family ;
Tissue Specificity	Expressed in all tissues.
Sequence	MVQRDMSKSPPTAAAAVAQEIQMELLENVAPAGALGAAAQSYGKGARRKNRFKGSDGSTS SDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVR TNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLE NMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIP ANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMM QKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIER IFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLN VQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTL ATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHN HRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDH RHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ
Function	The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Endogenous Substrate(s)	Ca2+
TCDB ID	8.A.22.1.2
Gene ID	783
KEGG Pathway	MAPK signaling pathway (hsa04010 ) Cardiac muscle contraction (hsa04260 ) Adrenergic signaling in cardiomyocytes (hsa04261 ) Oxytocin signaling pathway (hsa04921 ) Hypertrophic cardiomyopathy (hsa05410 ) Arrhythmogenic right ventricular cardiomyopathy (hsa05412 ) Dilated cardiomyopathy (hsa05414 )
Reactome Pathway	Adrenaline,noradrenaline inhibits insulin secretion (R-HSA-400042 ) NCAM1 interactions (R-HSA-419037 ) Regulation of insulin secretion (R-HSA-422356 ) Phase 0 - rapid depolarisation (R-HSA-5576892 ) Phase 2 - plateau phase (R-HSA-5576893 ) Sensory processing of sound by inner hair cells of the cochlea (R-HSA-9662360 ) Presynaptic depolarization and calcium channel opening (R-HSA-112308 )