Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTENHUP)

DTP Name	Potassium channel subfamily K member 2 (KCNK2)
Gene Name	KCNK2
UniProt ID	O95069 (KCNK2_HUMAN)
VARIDT ID	DTD0545
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Synonyms	Outward rectifying potassium channel protein TREK-1; TREK-1 K(+) channel subunit; Two pore domain potassium channel TREK-1; Two pore potassium channel TPKC1
DTP Family	Voltage-gated Ion Channel (VIC) Superfamily ;
Tissue Specificity	Isoform 4 is detected in kidney, adrenal gland and brain where it is preferentially expressed in the amygdala but not found in thalamus, hypothalamus, hippocampus or substantia nigra.
Sequence	MLPSASRERPGYRAGVAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWK TVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQQ IVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALL GIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVAL PAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYF AAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATS IKRKLSAELAGNHNQELTPCRRTLSVNHLTSERDVLPPLLKTESIYLNGLTPHCAGEEIA VIENIK
Function	This transporter can reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. Ion channel that contributes to passive transmembrane potassium transport.
TCDB ID	1.A.1.9.1
Gene ID	3776
KEGG Pathway	Cortisol synthesis and secretion (hsa04927 ) Cushing syndrome (hsa04934 ) Gastric acid secretion (hsa04971 )
Reactome Pathway	Phase 4 - resting membrane potential (R-HSA-5576886 ) TWIK related potassium channel (TREK) (R-HSA-1299503 )