Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTF7GAL)

DTP Name Anion exchange protein 2 (SLC4A2)
Gene Name SLC4A2
UniProt ID
P04920 (B3A2_HUMAN)
VARIDT ID
DTD0383
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms AE 2; AE2; Anion exchanger 2; BND3L; EPB3L1; HKB3; MPB3L; NBND3; Non-erythroid band 3-like protein; SLC4A2; Solute carrier family 4 member 2
DTP Family Anion Exchanger (AE) Family ;
Sequence
MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGE
EPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPT
IEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQ
EATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRR
IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSG
REGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERW
GKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVL
RALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEV
ERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREA
VELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLT
AINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKAL
LQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAAL
SPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFS
FCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETF
YKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNT
ALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQ
KLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIIS
KKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDK
PKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLH
LLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLR
MVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV
Function This transporter is a plasma membrane anion exchange protein of wide distribution.
Endogenous Substrate(s) Cl-
TCDB ID
2.A.31.1.2
Gene ID
6522
KEGG Pathway
Salivary secretion (hsa04970 )
Gastric acid secretion (hsa04971 )
Pancreatic secretion (hsa04972 )
Bile secretion (hsa04976 )
Reactome Pathway
Bicarbonate transporters (R-HSA-425381 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
1 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
BICARBONATE DMT5E36 Discovery agent N.A. Investigative [1]
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Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 3.83E-22 4.31E-01 1.16E+00
Adrenocortical carcinoma 2D11.Z Kidney 2.26E-01 1.11E-01 3.56E-01
Alopecia ED70 Skin from scalp 7.70E-01 6.04E-02 1.99E-01
Alzheimer's disease 8A20 Entorhinal cortex 2.08E-03 1.77E-01 3.78E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 5.27E-01 1.92E-02 8.71E-02
Aortic stenosis BB70 Calcified aortic valve 5.89E-02 4.67E-01 1.45E+00
Apnea 7A40 Hyperplastic tonsil 9.36E-01 -4.27E-02 -1.70E-01
Arthropathy FA00-FA5Z Peripheral blood 1.00E+00 1.47E-02 1.05E-01
Asthma CA23 Nasal and bronchial airway 4.14E-04 1.98E-01 3.52E-01
Atopic dermatitis EA80 Skin 1.85E-04 4.47E-01 1.71E+00
Autism 6A02 Whole blood 8.52E-01 7.94E-02 2.14E-01
Autoimmune uveitis 9A96 Peripheral monocyte 2.47E-01 1.85E-01 7.36E-01
Autosomal dominant monocytopenia 4B04 Whole blood 2.13E-01 -9.07E-02 -4.89E-01
Bacterial infection of gingival 1C1H Gingival tissue 4.36E-05 3.56E-01 7.46E-01
Batten disease 5C56.1 Whole blood 7.90E-01 8.27E-03 4.63E-02
Behcet's disease 4A62 Peripheral blood 5.30E-01 -9.02E-02 -3.57E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 2.61E-01 3.78E-02 1.39E-01
Bladder cancer 2C94 Bladder tissue 1.62E-01 3.63E-01 9.49E-01
Breast cancer 2C60-2C6Z Breast tissue 2.27E-24 5.83E-01 9.37E-01
Cardioembolic stroke 8B11.20 Whole blood 3.02E-02 -7.89E-02 -4.16E-01
Cervical cancer 2C77 Cervical tissue 5.01E-03 2.55E-01 7.71E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 7.51E-01 1.52E-02 4.41E-02
Chronic hepatitis C 1E51.1 Whole blood 3.41E-01 -5.72E-02 -4.87E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 3.76E-02 -3.41E-01 -8.00E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 7.02E-01 2.81E-02 6.17E-02
Chronic rhinosinusitis CA0A Sinus mucosa tissue 3.08E-03 2.64E-01 1.28E+00
Colon cancer 2B90 Colon tissue 4.47E-25 5.46E-01 1.17E+00
Coronary artery disease BA80-BA8Z Peripheral blood 7.06E-01 6.72E-03 2.15E-02
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 9.14E-02 -1.91E-01 -5.58E-01
Endometriosis GA10 Endometrium tissue 9.12E-01 1.54E-01 2.11E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 8.51E-01 2.47E-02 1.25E-01
Familial hypercholesterolemia 5C80.00 Whole blood 4.06E-05 2.21E-01 9.12E-01
Gastric cancer 2B72 Gastric tissue 8.28E-02 -1.34E+00 -1.95E+00
Glioblastopma 2A00.00 Nervous tissue 1.31E-15 4.78E-01 7.71E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 8.52E-03 1.72E+00 1.91E+00
Head and neck cancer 2D42 Head and neck tissue 5.87E-06 3.15E-01 7.49E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 1.52E-01 1.30E-01 3.00E-01
Huntington's disease 8A01.10 Whole blood 3.86E-01 1.10E-01 4.30E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 1.67E-01 2.90E-01 8.56E-01
Immunodeficiency 4A00-4A20 Peripheral blood 1.49E-01 1.18E-01 5.67E-01
Influenza 1.00E+30 Whole blood 3.31E-01 -2.87E-01 -6.85E-01
Interstitial cystitis GC00.3 Bladder tissue 9.43E-01 2.47E-01 5.13E-01
Intracranial aneurysm 8B01.0 Intracranial artery 5.21E-01 2.72E-01 3.05E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 6.09E-02 -8.76E-01 -1.20E+00
Ischemic stroke 8B11 Peripheral blood 4.66E-01 -9.91E-02 -4.53E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 5.50E-10 -1.08E+00 -1.62E+00
Lateral sclerosis 8B60.4 Cervical spinal cord 6.50E-01 -1.15E-01 -4.96E-01
Lateral sclerosis 8B60.4 Skin 2.42E-01 4.27E-01 1.21E+00
Liver cancer 2C12.0 Liver tissue 2.29E-04 3.89E-01 8.64E-01
Liver failure DB99.7-DB99.8 Liver tissue 5.15E-02 -5.24E-01 -9.72E-01
Lung cancer 2C25 Lung tissue 4.33E-27 -3.24E-01 -8.04E-01
Lupus erythematosus 4A40 Whole blood 1.22E-01 1.37E-01 1.63E-01
Major depressive disorder 6A70-6A7Z Whole blood 8.96E-01 -1.80E-02 -3.38E-02
Major depressive disorder 6A70-6A7Z Hippocampus 7.35E-01 -2.38E-02 -8.05E-02
Melanoma 2C30 Skin 1.41E-04 4.06E-01 8.31E-01
Multiple myeloma 2A83.1 Bone marrow 4.90E-02 2.72E-01 7.18E-01
Multiple myeloma 2A83.1 Peripheral blood 6.47E-01 -5.13E-02 -1.28E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 7.95E-01 1.15E-02 3.51E-02
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 4.42E-01 -1.03E-01 -2.06E-01
Myelofibrosis 2A20.2 Whole blood 1.98E-04 -1.74E-01 -1.02E+00
Myocardial infarction BA41-BA50 Peripheral blood 1.78E-02 -7.62E-01 -8.16E-01
Myopathy 8C70.6 Muscle tissue 6.32E-02 8.15E-02 4.78E-01
Neonatal sepsis KA60 Whole blood 1.60E-08 2.39E-01 5.12E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 7.62E-08 -1.92E+00 -4.74E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 2.77E-01 -1.89E-01 -3.02E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 1.42E-01 -1.30E-01 -1.01E+00
Olive pollen allergy CA08.00 Peripheral blood 7.88E-01 -2.61E-01 -8.46E-01
Oral cancer 2B6E Oral tissue 5.28E-02 2.79E-01 7.29E-01
Osteoarthritis FA00-FA0Z Synovial tissue 1.07E-01 7.08E-01 8.71E-01
Osteoporosis FB83.1 Bone marrow 5.70E-01 -2.28E-01 -3.81E-01
Ovarian cancer 2C73 Ovarian tissue 4.05E-01 3.73E-01 1.07E+00
Pancreatic cancer 2C10 Pancreas 3.14E-03 5.73E-01 1.34E+00
Parkinson's disease 8A00.0 Substantia nigra tissue 5.35E-02 1.62E-01 6.83E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 7.52E-02 1.76E-01 7.99E-01
Pituitary cancer 2D12 Pituitary tissue 8.40E-01 9.65E-02 2.20E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 2.46E-01 -6.24E-02 -1.60E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 8.61E-01 7.75E-02 6.53E-01
Polycythemia vera 2A20.4 Whole blood 3.17E-04 -1.13E-01 -6.50E-01
Pompe disease 5C51.3 Biceps muscle 1.60E-02 2.52E-01 1.24E+00
Preterm birth KA21.4Z Myometrium 7.88E-03 -3.27E-01 -2.37E+00
Prostate cancer 2C82 Prostate 8.19E-01 2.69E-01 4.98E-01
Psoriasis EA90 Skin 2.50E-03 1.63E-01 3.46E-01
Rectal cancer 2B92 Rectal colon tissue 4.27E-21 7.10E-01 1.17E+01
Renal cancer 2C90-2C91 Kidney 5.40E-05 -5.61E-01 -1.60E+00
Retinoblastoma 2D02.2 Uvea 4.65E-03 7.01E-01 3.69E+00
Rheumatoid arthritis FA20 Synovial tissue 4.94E-03 4.54E-01 1.39E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 9.26E-01 -3.41E-02 -2.38E-01
Schizophrenia 6A20 Prefrontal cortex 1.53E-01 6.67E-02 1.07E-01
Schizophrenia 6A20 Superior temporal cortex 1.53E-01 -9.07E-02 -5.13E-01
Scleroderma 4A42.Z Whole blood 2.16E-01 4.85E-03 3.91E-02
Seizure 8A60-8A6Z Whole blood 6.67E-01 2.57E-02 1.25E-01
Sensitive skin EK0Z Skin 1.83E-01 1.99E-01 7.90E-01
Sepsis with septic shock 1G41 Whole blood 6.04E-03 -3.38E-02 -7.25E-02
Shwachman-Diamond syndrome 3A70.0 Bone marrow 4.14E-02 -2.52E-01 -1.44E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 3.91E-01 1.56E-01 7.01E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 9.87E-01 4.13E-02 8.32E-02
Sjogren's syndrome 4A43.2 Salivary gland tissue 1.27E-02 1.43E+00 4.30E+00
Skin cancer 2C30-2C3Z Skin 4.29E-49 9.00E-01 1.91E+00
Thrombocythemia 3B63 Whole blood 2.71E-05 -1.67E-01 -9.42E-01
Thrombocytopenia 3B64 Whole blood 5.42E-01 4.35E-01 3.57E-01
Thyroid cancer 2D10 Thyroid 2.79E-04 1.09E-01 1.93E-01
Tibial muscular dystrophy 8C75 Muscle tissue 2.54E-04 4.43E-01 1.57E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 8.10E-02 6.16E-01 5.86E+00
Type 2 diabetes 5A11 Liver tissue 4.75E-01 -7.75E-02 -5.14E-01
Ureter cancer 2C92 Urothelium 6.57E-01 -1.16E-02 -6.83E-02
Uterine cancer 2C78 Endometrium tissue 5.97E-05 -3.13E-01 -3.46E-01
Vitiligo ED63.0 Skin 7.94E-01 2.71E-02 1.44E-01
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⏷ Show the Full List of Expression Under 107 Diseases

References

1 HCO3-/Cl- anion exchanger SLC4A2 is required for proper osteoclast differentiation and function. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16934-9.