Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTFPWJ9)

DTP Name Sodium-coupled citrate transporter (SLC13A5)
Gene Name SLC13A5
UniProt ID
Q86YT5 (S13A5_HUMAN)
VARIDT ID
DTD0095
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms EIEE25; INDY; Na(+)/citrate cotransporter; SLC13A5; Sodium-dependent citrate; NaCT transporter; Solute carrier family 13 member 5; mIndy
DTP Family Divalent Anion:Na(+) Symporter (DASS) Family ;
Tissue Specificity Expressed most predominantly in the liver,with moderate expression detectable in the brain and testis.
Sequence
MASALSYVSKFKSFVILFVTPLLLLPLVILMPAKFVRCAYVIILMAIYWCTEVIPLAVTS
LMPVLLFPLFQILDSRQVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAK
PARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQMEATSAATEAGLELVDKGKAKE
LPGSQVIFEGPTLGQQEDQERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNEL
FPDSKDLVNFASWFAFAFPNMLVMLLFAWLWLQFVYMRFNFKKSWGCGLESKKNEKAALK
VLQEEYRKLGPLSFAEINVLICFFLLVILWFSRDPGFMPGWLTVAWVEGETKYVSDATVA
IFVATLLFIVPSQKPKFNFRSQTEEERKTPFYPPPLLDWKVTQEKVPWGIVLLLGGGFAL
AKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMS
RSIGLNPLYIMLPCTLSASFAFMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCV
FLAVNTWGRAIFDLDHFPDWANVTHIET
Function
This sodium/citrate cotransporter can mediate citrate entry into cells. It is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol.
Endogenous Substrate(s) Na+; Citrate; Dicarboxylates; Tricarboxylates
TCDB ID
2.A.47.1.9
Gene ID
284111
Reactome Pathway
Sodium-coupled sulphate, di- and tri-carboxylate transporters (R-HSA-433137 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
1 Preclinical Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Citrate DM37NYK N. A. N. A. Preclinical [1]
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2 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
alpha-ketoglutaric acid DM5LFYN Discovery agent N.A. Investigative [1]
Succinate DMPY09A N. A. N. A. Investigative [1]
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Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 1.27E-02 5.41E-02 2.46E-01
Adrenocortical carcinoma 2D11.Z Kidney 1.92E-01 -3.52E-01 -3.52E-01
Alopecia ED70 Skin from scalp 3.80E-02 7.85E-02 3.39E-01
Alzheimer's disease 8A20 Entorhinal cortex 1.45E-01 8.73E-03 1.45E-02
Ankylosing spondylitis FA92.0 Pheripheral blood 8.13E-01 4.18E-02 2.80E-01
Aortic stenosis BB70 Calcified aortic valve 7.36E-01 -6.52E-02 -7.50E-02
Apnea 7A40 Hyperplastic tonsil 4.54E-01 -9.12E-02 -5.82E-02
Arthropathy FA00-FA5Z Peripheral blood 1.95E-01 -1.16E-01 -7.62E-01
Asthma CA23 Nasal and bronchial airway 7.30E-02 8.85E-02 1.78E-01
Atopic dermatitis EA80 Skin 9.77E-02 4.52E-03 1.82E-02
Autism 6A02 Whole blood 4.13E-01 -2.02E-02 -9.93E-02
Autoimmune uveitis 9A96 Peripheral monocyte 5.27E-02 -2.18E-01 -1.44E+00
Autosomal dominant monocytopenia 4B04 Whole blood 5.26E-01 1.79E-02 9.63E-02
Bacterial infection of gingival 1C1H Gingival tissue 7.32E-04 5.84E-01 6.28E-01
Batten disease 5C56.1 Whole blood 3.04E-01 9.45E-02 9.35E-01
Behcet's disease 4A62 Peripheral blood 4.40E-01 2.93E-02 1.23E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 7.12E-01 -4.21E-02 -9.92E-02
Bladder cancer 2C94 Bladder tissue 1.97E-04 9.01E-01 2.89E+00
Breast cancer 2C60-2C6Z Breast tissue 2.53E-12 -2.09E-01 -4.72E-01
Cardioembolic stroke 8B11.20 Whole blood 2.19E-02 -3.17E-01 -7.99E-01
Cervical cancer 2C77 Cervical tissue 2.17E-01 -6.96E-02 -2.95E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 3.15E-01 -1.45E-01 -3.83E-01
Chronic hepatitis C 1E51.1 Whole blood 3.36E-02 1.66E-01 1.03E+00
Chronic obstructive pulmonary disease CA22 Lung tissue 1.85E-01 8.55E-02 3.72E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 6.71E-02 1.16E-01 5.39E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 4.83E-01 1.05E-01 1.45E-01
Colon cancer 2B90 Colon tissue 3.29E-07 8.53E-02 2.87E-01
Coronary artery disease BA80-BA8Z Peripheral blood 5.24E-01 -1.91E-01 -8.50E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 5.52E-01 1.81E-02 7.48E-02
Endometriosis GA10 Endometrium tissue 2.62E-01 9.53E-02 3.79E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 6.25E-01 4.02E-02 2.85E-01
Familial hypercholesterolemia 5C80.00 Whole blood 2.11E-03 -2.49E-01 -1.02E+00
Gastric cancer 2B72 Gastric tissue 1.58E-01 -4.12E-01 -2.00E+00
Glioblastopma 2A00.00 Nervous tissue 5.43E-68 -8.93E-01 -1.41E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 3.02E-03 -6.93E-01 -1.40E+00
Head and neck cancer 2D42 Head and neck tissue 3.27E-11 2.34E-01 9.54E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 4.68E-01 -1.02E-01 -2.45E-01
Huntington's disease 8A01.10 Whole blood 8.45E-01 -9.64E-04 -8.28E-03
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 8.42E-01 -1.61E-02 -5.65E-02
Immunodeficiency 4A00-4A20 Peripheral blood 3.15E-01 5.74E-02 6.43E-01
Influenza 1.00E+30 Whole blood 6.51E-01 8.23E-02 1.81E-01
Interstitial cystitis GC00.3 Bladder tissue 1.61E-01 1.26E-01 6.92E-01
Intracranial aneurysm 8B01.0 Intracranial artery 1.05E-01 7.20E-02 3.57E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 7.27E-01 1.02E-01 2.17E-01
Ischemic stroke 8B11 Peripheral blood 5.99E-01 3.52E-02 2.60E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 6.98E-02 -1.40E-01 -4.67E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 8.75E-01 1.07E-01 2.69E-01
Lateral sclerosis 8B60.4 Skin 8.58E-01 -3.34E-02 -5.58E-01
Liver cancer 2C12.0 Liver tissue 4.65E-31 -1.05E+00 -2.02E+00
Liver failure DB99.7-DB99.8 Liver tissue 2.14E-05 -5.42E+00 -1.00E+01
Lung cancer 2C25 Lung tissue 1.13E-02 -5.66E-02 -2.17E-01
Lupus erythematosus 4A40 Whole blood 8.18E-04 -6.42E-02 -2.19E-01
Major depressive disorder 6A70-6A7Z Whole blood 7.14E-01 -2.87E-02 -9.16E-02
Major depressive disorder 6A70-6A7Z Hippocampus 3.45E-01 -2.72E-01 -6.26E-01
Melanoma 2C30 Skin 1.21E-01 5.94E-01 9.02E-01
Multiple myeloma 2A83.1 Bone marrow 4.12E-02 -1.87E-01 -1.02E+00
Multiple myeloma 2A83.1 Peripheral blood 9.37E-01 6.19E-02 4.63E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 8.16E-02 2.45E-01 7.66E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 9.58E-01 4.36E-02 2.52E-01
Myelofibrosis 2A20.2 Whole blood 2.57E-01 1.23E-01 7.65E-01
Myocardial infarction BA41-BA50 Peripheral blood 5.38E-01 5.93E-02 1.30E-01
Myopathy 8C70.6 Muscle tissue 8.33E-01 -2.14E-02 -1.24E-01
Neonatal sepsis KA60 Whole blood 1.21E-01 9.33E-02 3.64E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 7.99E-07 -1.52E+00 -3.86E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 1.07E-01 2.53E-01 6.68E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 2.06E-01 -1.90E-02 -3.05E-01
Olive pollen allergy CA08.00 Peripheral blood 8.92E-01 -4.87E-02 -1.21E+00
Oral cancer 2B6E Oral tissue 8.45E-02 -4.48E-01 -3.40E-01
Osteoarthritis FA00-FA0Z Synovial tissue 7.09E-01 -6.39E-02 -2.79E-01
Osteoporosis FB83.1 Bone marrow 2.67E-01 7.39E-02 4.09E-01
Ovarian cancer 2C73 Ovarian tissue 1.81E-01 -9.38E-02 -2.42E-01
Pancreatic cancer 2C10 Pancreas 2.19E-09 1.97E-01 7.02E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 2.10E-01 -2.76E-01 -5.03E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 9.03E-01 3.63E-02 2.48E-01
Pituitary cancer 2D12 Pituitary tissue 1.40E-01 -1.48E-01 -3.36E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 1.24E-01 -1.71E-01 -5.09E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 6.93E-01 2.84E-02 1.89E-01
Polycythemia vera 2A20.4 Whole blood 4.21E-04 1.37E-01 7.22E-01
Pompe disease 5C51.3 Biceps muscle 5.29E-01 -7.19E-02 -5.02E-01
Preterm birth KA21.4Z Myometrium 2.53E-01 -1.35E-02 -1.09E-01
Prostate cancer 2C82 Prostate 3.61E-04 -7.20E-01 -1.20E+00
Psoriasis EA90 Skin 9.35E-01 -3.59E-02 -8.89E-02
Rectal cancer 2B92 Rectal colon tissue 1.80E-01 -2.03E-02 -9.88E-02
Renal cancer 2C90-2C91 Kidney 1.01E-01 -3.52E-01 -3.71E-01
Retinoblastoma 2D02.2 Uvea 7.73E-06 -1.13E+00 -2.73E+00
Rheumatoid arthritis FA20 Synovial tissue 4.07E-01 1.66E-01 5.38E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 1.60E-01 4.34E-02 2.65E-01
Schizophrenia 6A20 Prefrontal cortex 1.11E-01 -2.68E-01 -3.85E-01
Schizophrenia 6A20 Superior temporal cortex 9.12E-02 -9.75E-02 -5.23E-01
Scleroderma 4A42.Z Whole blood 1.00E-01 -1.63E-01 -1.09E+00
Seizure 8A60-8A6Z Whole blood 3.58E-01 1.43E-02 8.00E-02
Sensitive skin EK0Z Skin 8.24E-01 3.57E-02 1.77E-01
Sepsis with septic shock 1G41 Whole blood 2.72E-01 -2.38E-02 -8.73E-02
Shwachman-Diamond syndrome 3A70.0 Bone marrow 2.62E-01 1.76E-01 3.58E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 1.58E-01 7.59E-02 3.45E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 3.26E-02 1.53E-01 1.56E+00
Sjogren's syndrome 4A43.2 Salivary gland tissue 4.92E-04 2.46E-01 7.42E+00
Skin cancer 2C30-2C3Z Skin 4.84E-01 -1.25E-01 -2.80E-01
Thrombocythemia 3B63 Whole blood 3.25E-05 1.49E-01 9.02E-01
Thrombocytopenia 3B64 Whole blood 2.23E-01 3.82E-01 5.63E-01
Thyroid cancer 2D10 Thyroid 7.55E-01 -6.39E-02 -2.83E-01
Tibial muscular dystrophy 8C75 Muscle tissue 2.42E-01 -1.43E-01 -8.66E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 3.63E-01 -6.63E-01 -1.67E+00
Type 2 diabetes 5A11 Liver tissue 1.66E-02 -3.66E-01 -1.44E+00
Ureter cancer 2C92 Urothelium 9.99E-01 -4.26E-03 -2.98E-02
Uterine cancer 2C78 Endometrium tissue 9.32E-01 -1.38E-01 -3.65E-01
Vitiligo ED63.0 Skin 8.63E-01 3.89E-02 3.08E-01
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⏷ Show the Full List of Expression Under 107 Diseases

The Drug Therapeutic Target (DTT) Role of This DTP

DTP DTT Name Solute carrier family 13 member 5 (SLC13A5) DTT Info
DTP DTT Type Literature-reported

References

1 SLC13 family of Na+ coupled di- and tri-carboxylate/sulfate transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):299-312.