Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTGQ7FH)

DTP Name Sodium-dependent neutral amino acid transporter B(0)AT3 (SLC6A18)
Gene Name SLC6A18
UniProt ID
Q96N87 (S6A18_HUMAN)
VARIDT ID
DTD0450
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Synonyms
SLC6A18; Sodium- and chloride-dependent transporter XTRP2; Solute carrier family 6 member 18; Inactive sodium-dependent neutral amino acid transporter B(0)AT3; XTRP2; B(0)AT3; System B(0) neutral amino acid transporter AT3
DTP Family Neurotransmitter:Sodium Symporter (NSS) Family ;
Tissue Specificity Abundantly expressed in kidney, but not inintestine.
Sequence
MAHAPEPDPAACDLGDERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPY
VIALVFEGIPIFHVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVA
WVLWYLLNSFQHPLPWSSCPPDLNRTGFVEECQGSSAVSYFWYRQTLNITADINDSGSIQ
WWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYL
FTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTS
LYASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKR
VAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFG
TVEAVITPLLDVGVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPNL
LMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLLTIFVAYIILLFW
KPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTRRRRTWRD
RDARPDTDMRPDTDTRPDTDMRPDTDMR
Function This transporter does not show neutral amino acid transporter activity.
Endogenous Substrate(s) Neutral amino acids
TCDB ID
2.A.22.6.4
Gene ID
348932
Reactome Pathway
Na+/Cl- dependent neurotransmitter transporters (R-HSA-442660 )
Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria (R-HSA-5619079 )
Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria (R-HSA-5659729 )
Amino acid transport across the plasma membrane (R-HSA-352230 )

Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 1.72E-02 3.95E-02 2.07E-01
Adrenocortical carcinoma 2D11.Z Kidney 9.21E-01 5.21E-03 2.17E-02
Alopecia ED70 Skin from scalp 8.90E-02 -8.98E-02 -3.22E-01
Alzheimer's disease 8A20 Entorhinal cortex 4.86E-01 -1.05E-02 -6.29E-02
Ankylosing spondylitis FA92.0 Pheripheral blood 5.26E-01 3.21E-02 3.71E-01
Aortic stenosis BB70 Calcified aortic valve 9.92E-01 -7.75E-02 -1.39E-01
Apnea 7A40 Hyperplastic tonsil 7.02E-01 7.93E-02 3.27E-01
Arthropathy FA00-FA5Z Peripheral blood 9.92E-01 0.00E+00 0.00E+00
Asthma CA23 Nasal and bronchial airway 3.71E-03 -1.26E-01 -2.72E-01
Atopic dermatitis EA80 Skin 4.19E-01 -2.49E-02 -2.04E-01
Autism 6A02 Whole blood 7.09E-01 -1.15E-02 -3.93E-02
Autoimmune uveitis 9A96 Peripheral monocyte 6.23E-03 -3.56E-01 -2.13E+00
Autosomal dominant monocytopenia 4B04 Whole blood 7.01E-01 -4.33E-03 -2.40E-02
Bacterial infection of gingival 1C1H Gingival tissue 5.65E-01 6.07E-02 3.03E-01
Batten disease 5C56.1 Whole blood 6.19E-01 1.79E-01 8.68E-01
Behcet's disease 4A62 Peripheral blood 4.63E-01 2.55E-01 8.88E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 3.07E-01 2.05E-02 1.15E-01
Bladder cancer 2C94 Bladder tissue 2.74E-03 4.55E-01 1.94E+00
Breast cancer 2C60-2C6Z Breast tissue 2.57E-01 3.10E-02 1.16E-01
Cardioembolic stroke 8B11.20 Whole blood 1.18E-02 9.18E-02 4.13E-01
Cervical cancer 2C77 Cervical tissue 8.03E-02 -8.32E-02 -4.10E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 4.10E-01 -2.33E-03 -1.17E-02
Chronic hepatitis C 1E51.1 Whole blood 6.63E-01 1.72E-02 1.19E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 4.92E-01 -6.62E-02 -2.87E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 7.91E-05 2.24E-01 6.86E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 9.14E-01 -5.89E-02 -2.75E-01
Colon cancer 2B90 Colon tissue 1.13E-03 -9.40E-02 -2.90E-01
Coronary artery disease BA80-BA8Z Peripheral blood 9.25E-01 5.20E-03 2.98E-02
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 8.66E-01 6.45E-02 2.52E-01
Endometriosis GA10 Endometrium tissue 3.44E-01 8.78E-02 2.86E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 1.93E-01 5.06E-02 5.98E-01
Familial hypercholesterolemia 5C80.00 Whole blood 7.30E-01 -4.92E-03 -2.24E-02
Gastric cancer 2B72 Gastric tissue 3.17E-01 -7.73E-01 -1.30E+00
Glioblastopma 2A00.00 Nervous tissue 4.99E-63 -3.69E-01 -1.17E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 4.28E-03 -4.52E-01 -1.04E+00
Head and neck cancer 2D42 Head and neck tissue 4.88E-01 -1.08E-02 -3.01E-02
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 5.07E-01 -1.72E-02 -1.21E-01
Huntington's disease 8A01.10 Whole blood 1.11E-01 5.18E-02 7.77E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 6.00E-01 8.60E-03 9.55E-02
Immunodeficiency 4A00-4A20 Peripheral blood 7.21E-02 5.67E-02 4.75E-01
Influenza 1.00E+30 Whole blood 1.35E-01 3.13E-01 1.67E+00
Interstitial cystitis GC00.3 Bladder tissue 5.67E-01 2.16E-02 1.84E-01
Intracranial aneurysm 8B01.0 Intracranial artery 4.89E-01 -4.37E-02 -1.73E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 4.80E-01 8.89E-02 3.14E-01
Ischemic stroke 8B11 Peripheral blood 4.07E-02 6.23E-02 2.26E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 1.52E-03 1.66E-01 5.75E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 1.88E-01 3.21E-02 1.31E-01
Lateral sclerosis 8B60.4 Skin 7.45E-01 -1.42E-01 -4.57E-01
Liver cancer 2C12.0 Liver tissue 3.68E-03 -2.03E-01 -6.72E-01
Liver failure DB99.7-DB99.8 Liver tissue 4.11E-01 1.42E-01 4.71E-01
Lung cancer 2C25 Lung tissue 1.56E-02 -6.83E-02 -2.76E-01
Lupus erythematosus 4A40 Whole blood 7.24E-01 -1.12E-01 -2.37E-01
Major depressive disorder 6A70-6A7Z Whole blood 4.06E-01 -3.57E-03 -1.57E-02
Major depressive disorder 6A70-6A7Z Hippocampus 7.98E-01 -1.78E-02 -1.09E-01
Melanoma 2C30 Skin 6.60E-01 1.02E-01 1.76E-01
Multiple myeloma 2A83.1 Bone marrow 2.50E-02 2.75E-01 9.50E-01
Multiple myeloma 2A83.1 Peripheral blood 5.73E-01 -5.11E-02 -1.75E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 2.01E-01 -1.12E-01 -5.61E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 3.52E-04 -1.10E-01 -7.54E-01
Myelofibrosis 2A20.2 Whole blood 6.60E-01 -5.74E-02 -3.46E-01
Myocardial infarction BA41-BA50 Peripheral blood 5.15E-02 3.48E-01 8.20E-01
Myopathy 8C70.6 Muscle tissue 8.41E-02 -2.04E-01 -1.28E+00
Neonatal sepsis KA60 Whole blood 6.59E-01 3.92E-03 1.09E-02
Neuroectodermal tumour 2A00.11 Brain stem tissue 7.42E-03 -3.88E-01 -1.01E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 5.14E-01 -3.26E-02 -1.60E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 5.36E-01 3.25E-02 3.65E-01
Olive pollen allergy CA08.00 Peripheral blood 7.31E-01 6.69E-02 3.16E-01
Oral cancer 2B6E Oral tissue 4.50E-08 -4.16E-01 -1.39E+00
Osteoarthritis FA00-FA0Z Synovial tissue 2.87E-01 1.78E-02 7.37E-02
Osteoporosis FB83.1 Bone marrow 5.55E-01 0.00E+00 0.00E+00
Ovarian cancer 2C73 Ovarian tissue 6.59E-02 -1.97E-01 -6.75E-01
Pancreatic cancer 2C10 Pancreas 1.48E-01 -2.58E-01 -7.11E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 9.72E-01 5.57E-02 4.13E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 3.49E-01 1.97E-02 1.06E-01
Pituitary cancer 2D12 Pituitary tissue 1.96E-02 2.12E-01 1.12E+00
Pituitary gonadotrope tumour 2D12 Pituitary tissue 4.03E-01 1.22E-01 7.70E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 4.52E-01 1.20E-01 4.10E-01
Polycythemia vera 2A20.4 Whole blood 1.97E-02 4.70E-02 3.14E-01
Pompe disease 5C51.3 Biceps muscle 1.45E-02 -1.53E-01 -1.03E+00
Preterm birth KA21.4Z Myometrium 4.18E-01 5.55E-02 8.64E-01
Prostate cancer 2C82 Prostate 2.80E-01 -1.72E-02 -3.57E-02
Psoriasis EA90 Skin 5.21E-01 3.98E-02 9.61E-02
Rectal cancer 2B92 Rectal colon tissue 7.08E-01 3.44E-02 1.57E-01
Renal cancer 2C90-2C91 Kidney 1.24E-01 -5.52E-01 -5.63E-01
Retinoblastoma 2D02.2 Uvea 7.09E-04 -2.52E-01 -1.33E+00
Rheumatoid arthritis FA20 Synovial tissue 3.76E-01 -3.18E-01 -7.35E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 9.14E-01 4.69E-04 2.81E-03
Schizophrenia 6A20 Prefrontal cortex 2.23E-01 -2.70E-03 -8.77E-03
Schizophrenia 6A20 Superior temporal cortex 2.33E-01 -1.79E-02 -1.39E-01
Scleroderma 4A42.Z Whole blood 1.41E-03 -2.52E-01 -1.48E+00
Seizure 8A60-8A6Z Whole blood 7.65E-02 1.31E-01 9.98E-01
Sensitive skin EK0Z Skin 8.93E-01 -2.21E-02 -8.87E-02
Sepsis with septic shock 1G41 Whole blood 1.38E-01 -7.22E-02 -2.12E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 8.83E-01 2.76E-02 2.48E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 6.70E-02 2.00E-01 5.60E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 6.95E-01 4.49E-02 2.85E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 7.13E-01 -7.35E-02 -3.76E-01
Skin cancer 2C30-2C3Z Skin 1.18E-01 9.41E-02 2.31E-01
Thrombocythemia 3B63 Whole blood 3.53E-01 1.49E-02 1.02E-01
Thrombocytopenia 3B64 Whole blood 6.85E-01 7.18E-02 1.69E-01
Thyroid cancer 2D10 Thyroid 9.76E-08 1.79E-01 6.26E-01
Tibial muscular dystrophy 8C75 Muscle tissue 7.97E-06 -5.80E-01 -2.10E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 5.10E-01 3.31E-02 2.37E-01
Type 2 diabetes 5A11 Liver tissue 4.05E-01 -1.34E-01 -5.00E-01
Ureter cancer 2C92 Urothelium 7.28E-01 -1.99E-02 -7.23E-02
Uterine cancer 2C78 Endometrium tissue 1.28E-01 -2.80E-02 -9.67E-02
Vitiligo ED63.0 Skin 5.05E-01 -1.18E-01 -6.01E-01
------------------------------------------------------------------------------------
⏷ Show the Full List of Expression Under 107 Diseases