Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTI6LSR)

DTP Name Sodium/hydrogen exchanger 5 (SLC9A5)
Gene Name SLC9A5
UniProt ID
Q14940 (SL9A5_HUMAN)
VARIDT ID
DTD0489
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms NHE-5; NHE5; Na(+)/H(+) exchanger 5; SLC9A5; Solute carrier family 9 member 5
DTP Family Monovalent Cation:Proton Antiporter-1 (CPA1) family ;
Tissue Specificity Expressed in brain, testis, spleen, andskeletal muscle.
Sequence
MLRAALSLLALPLAGAAEEPTQKPESPGEPPPGLELFRWQWHEVEAPYLVALWILVASLA
KIVFHLSRKVTSLVPESCLLILLGLVLGGIVLAVAKKAEYQLEPGTFFLFLLPPIVLDSG
YFMPSRLFFDNLGAILTYAVVGTLWNAFTTGAALWGLQQAGLVAPRVQAGLLDFLLFGSL
ISAVDPVAVLAVFEEVHVNETLFIIVFGESLLNDAVTVVLYKVCNSFVEMGSANVQATDY
LKGVASLFVVSLGGAAVGLVFAFLLALTTRFTKRVRIIEPLLVFLLAYAAYLTAEMASLS
AILAVTMCGLGCKKYVEANISHKSRTTVKYTMKTLASCAETVIFMLLGISAVDSSKWAWD
SGLVLGTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMSYGGLRGAVAFALVILLD
RTKVPAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLKVKRSEHHKPTLNQELHEHTFDHI
LAAVEDVVGHHGYHYWRDRWEQFDKKYLSQLLMRRSAYRIRDQIWDVYYRLNIRDAISFV
DQGGHVLSSTGLTLPSMPSRNSVAETSVTNLLRESGSGACLDLQVIDTVRSGRDREDAVM
HHLLCGGLYKPRRRYKASCSRHFISEDAQERQDKEVFQQNMKRRLESFKSTKHNICFTKS
KPRPRKTGRRKKDGVANAEATNGKHRGLGFQDTAAVILTVESEEEEEESDSSETEKEDDE
GIIFVARATSEVLQEGKVSGSLEVCPSPRIIPPSPTCAEKELPWKSGQGDLAVYVSSETT
KIVPVDMQTGWNQSISSLESLASPPCNQAPILTCLPPHPRGTEEPQVPLHLPSDPRSSFA
FPPSLAKAGRSRSESSADLPQQQELQPLMGHKDHTHLSPGTATSHWCIQFNRGSRL
Function This transporter mediates and participates in regulating pH value to eliminate acids generated by active metabolism or to combat adverse environmental conditions.
Endogenous Substrate(s) Na+; H+
TCDB ID
2.A.36.1.16
Gene ID
6553
Reactome Pathway
Sodium/Proton exchangers (R-HSA-425986 )

Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 6.99E-06 1.01E-01 5.57E-01
Adrenocortical carcinoma 2D11.Z Kidney 8.10E-02 -9.49E-02 -5.76E-01
Alopecia ED70 Skin from scalp 1.54E-01 -1.48E-01 -5.78E-01
Alzheimer's disease 8A20 Entorhinal cortex 4.89E-01 -7.84E-03 -6.27E-02
Ankylosing spondylitis FA92.0 Pheripheral blood 5.37E-01 5.84E-02 3.25E-01
Aortic stenosis BB70 Calcified aortic valve 8.67E-01 1.48E-01 2.85E-01
Apnea 7A40 Hyperplastic tonsil 8.49E-01 -4.06E-03 -2.22E-02
Arthropathy FA00-FA5Z Peripheral blood 9.11E-02 9.27E-02 6.03E-01
Asthma CA23 Nasal and bronchial airway 7.58E-02 -7.22E-02 -1.23E-01
Atopic dermatitis EA80 Skin 3.83E-02 7.00E-02 7.83E-01
Autism 6A02 Whole blood 4.88E-01 -2.99E-02 -1.42E-01
Autoimmune uveitis 9A96 Peripheral monocyte 7.04E-02 -3.07E-01 -2.88E+00
Autosomal dominant monocytopenia 4B04 Whole blood 6.27E-01 1.61E-02 1.17E-01
Bacterial infection of gingival 1C1H Gingival tissue 9.05E-03 9.04E-02 4.21E-01
Batten disease 5C56.1 Whole blood 5.97E-01 2.11E-02 3.44E-01
Behcet's disease 4A62 Peripheral blood 6.14E-01 -1.05E-02 -6.37E-02
Bipolar disorder 6A60-6A6Z Prefrontal cortex 9.19E-01 -7.74E-04 -5.63E-03
Bladder cancer 2C94 Bladder tissue 1.46E-04 4.39E-01 2.92E+00
Breast cancer 2C60-2C6Z Breast tissue 8.58E-01 2.51E-02 9.71E-02
Cardioembolic stroke 8B11.20 Whole blood 9.54E-01 -4.80E-02 -2.00E-01
Cervical cancer 2C77 Cervical tissue 2.26E-01 -6.15E-02 -2.42E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 8.38E-01 4.83E-02 2.29E-01
Chronic hepatitis C 1E51.1 Whole blood 7.84E-01 -3.60E-02 -2.38E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 3.52E-01 -1.30E-02 -7.74E-02
Chronic obstructive pulmonary disease CA22 Small airway epithelium 2.32E-03 1.08E-01 4.65E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 6.49E-01 -8.55E-02 -6.01E-01
Colon cancer 2B90 Colon tissue 2.14E-01 -2.36E-02 -1.04E-01
Coronary artery disease BA80-BA8Z Peripheral blood 2.10E-01 -8.35E-02 -2.36E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 9.79E-01 6.96E-02 1.94E-01
Endometriosis GA10 Endometrium tissue 3.20E-01 -6.93E-02 -2.39E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 9.34E-01 -7.68E-02 -3.52E-01
Familial hypercholesterolemia 5C80.00 Whole blood 9.57E-01 1.29E-01 4.75E-01
Gastric cancer 2B72 Gastric tissue 6.35E-01 -1.73E-01 -5.44E-01
Glioblastopma 2A00.00 Nervous tissue 1.46E-45 -2.12E-01 -8.52E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 2.67E-03 -4.67E-01 -1.46E+00
Head and neck cancer 2D42 Head and neck tissue 4.36E-11 1.73E-01 9.52E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 6.52E-02 -1.77E-01 -6.39E-01
Huntington's disease 8A01.10 Whole blood 6.44E-01 1.03E-01 1.27E+00
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 1.38E-03 1.56E-01 3.15E+00
Immunodeficiency 4A00-4A20 Peripheral blood 5.61E-01 -8.78E-03 -8.42E-02
Influenza 1.00E+30 Whole blood 4.90E-02 1.76E-01 4.07E+00
Interstitial cystitis GC00.3 Bladder tissue 3.10E-01 3.96E-02 1.75E-01
Intracranial aneurysm 8B01.0 Intracranial artery 7.28E-01 8.14E-03 5.81E-02
Irritable bowel syndrome DD91.0 Rectal colon tissue 3.80E-01 -7.18E-03 -2.16E-02
Ischemic stroke 8B11 Peripheral blood 4.45E-02 1.04E-01 6.57E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 7.87E-01 7.08E-03 2.86E-02
Lateral sclerosis 8B60.4 Cervical spinal cord 3.89E-01 1.31E-01 5.19E-01
Lateral sclerosis 8B60.4 Skin 9.10E-01 5.56E-03 4.99E-02
Liver cancer 2C12.0 Liver tissue 1.77E-02 -1.45E-01 -4.24E-01
Liver failure DB99.7-DB99.8 Liver tissue 8.95E-01 -3.40E-02 -2.12E-01
Lung cancer 2C25 Lung tissue 7.66E-02 -1.52E-02 -8.21E-02
Lupus erythematosus 4A40 Whole blood 4.98E-02 -4.65E-02 -1.72E-01
Major depressive disorder 6A70-6A7Z Whole blood 7.79E-02 9.48E-02 3.88E-01
Major depressive disorder 6A70-6A7Z Hippocampus 9.82E-01 -1.20E-02 -7.75E-02
Melanoma 2C30 Skin 2.19E-01 2.72E-02 6.95E-02
Multiple myeloma 2A83.1 Bone marrow 2.85E-02 -1.70E-01 -7.35E-01
Multiple myeloma 2A83.1 Peripheral blood 8.17E-01 1.91E-03 9.80E-03
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 3.46E-01 -1.56E-01 -3.85E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 2.75E-01 -1.83E-02 -1.08E-01
Myelofibrosis 2A20.2 Whole blood 3.40E-01 2.34E-03 1.62E-02
Myocardial infarction BA41-BA50 Peripheral blood 8.88E-01 -1.95E-02 -6.30E-02
Myopathy 8C70.6 Muscle tissue 3.38E-02 -1.74E-01 -9.84E-01
Neonatal sepsis KA60 Whole blood 1.55E-04 -1.40E-01 -5.30E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 3.32E-03 -2.47E-01 -1.35E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 2.72E-02 -1.39E-01 -1.14E+00
Obesity related type 2 diabetes 5A11 Omental adipose tissue 6.53E-01 -3.94E-02 -2.95E-01
Olive pollen allergy CA08.00 Peripheral blood 7.48E-01 -1.89E-02 -5.94E-02
Oral cancer 2B6E Oral tissue 2.55E-06 -4.13E-01 -1.52E+00
Osteoarthritis FA00-FA0Z Synovial tissue 7.94E-01 -1.06E-01 -5.97E-01
Osteoporosis FB83.1 Bone marrow 4.09E-02 1.50E-01 3.81E+00
Ovarian cancer 2C73 Ovarian tissue 1.48E-02 -1.82E-01 -7.82E-01
Pancreatic cancer 2C10 Pancreas 9.54E-01 1.07E-02 3.57E-02
Parkinson's disease 8A00.0 Substantia nigra tissue 8.36E-01 -7.35E-03 -5.34E-02
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 2.03E-01 -5.25E-02 -4.74E-01
Pituitary cancer 2D12 Pituitary tissue 3.16E-02 9.46E-02 7.57E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 2.26E-01 -1.16E-01 -7.89E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 9.37E-01 -3.31E-02 -1.16E-01
Polycythemia vera 2A20.4 Whole blood 3.76E-04 8.30E-02 5.06E-01
Pompe disease 5C51.3 Biceps muscle 2.02E-01 -2.59E-02 -1.89E-01
Preterm birth KA21.4Z Myometrium 5.80E-01 -4.67E-02 -7.61E-01
Prostate cancer 2C82 Prostate 7.92E-03 9.20E-02 2.83E-01
Psoriasis EA90 Skin 3.08E-01 3.66E-02 1.18E-01
Rectal cancer 2B92 Rectal colon tissue 1.35E-01 5.35E-02 3.35E-01
Renal cancer 2C90-2C91 Kidney 1.02E-02 -1.85E-01 -8.29E-01
Retinoblastoma 2D02.2 Uvea 6.25E-05 -3.85E-01 -4.10E+00
Rheumatoid arthritis FA20 Synovial tissue 6.19E-01 5.05E-02 1.41E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 4.94E-01 -3.34E-02 -2.41E-01
Schizophrenia 6A20 Prefrontal cortex 2.68E-01 1.24E-02 7.60E-02
Schizophrenia 6A20 Superior temporal cortex 9.14E-02 3.29E-02 2.56E-01
Scleroderma 4A42.Z Whole blood 9.86E-03 8.74E-02 7.91E-01
Seizure 8A60-8A6Z Whole blood 8.07E-01 9.22E-03 4.55E-02
Sensitive skin EK0Z Skin 6.38E-01 -4.22E-02 -2.09E-01
Sepsis with septic shock 1G41 Whole blood 1.45E-06 -9.62E-02 -3.26E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 9.16E-01 2.71E-02 1.41E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 1.59E-01 1.16E-01 6.52E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 2.50E-01 -1.50E-01 -1.46E+00
Sjogren's syndrome 4A43.2 Salivary gland tissue 8.78E-01 1.11E-01 6.87E-01
Skin cancer 2C30-2C3Z Skin 9.61E-07 -1.56E-01 -4.93E-01
Thrombocythemia 3B63 Whole blood 4.54E-03 5.55E-02 3.77E-01
Thrombocytopenia 3B64 Whole blood 1.66E-01 3.22E-01 1.30E+00
Thyroid cancer 2D10 Thyroid 4.08E-14 1.64E-01 8.33E-01
Tibial muscular dystrophy 8C75 Muscle tissue 3.01E-04 -3.76E-01 -1.52E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 5.68E-01 6.98E-02 6.58E-01
Type 2 diabetes 5A11 Liver tissue 3.52E-01 -8.94E-02 -4.29E-01
Ureter cancer 2C92 Urothelium 6.94E-01 1.30E-01 7.25E-01
Uterine cancer 2C78 Endometrium tissue 1.15E-06 -1.66E-01 -5.13E-01
Vitiligo ED63.0 Skin 8.99E-01 -9.90E-02 -4.06E-01
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