Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTI9CQU)

DTP Name Sugar transporter SWEET1 (SLC50A1)
Gene Name SLC50A1
UniProt ID
Q9BRV3 (SWET1_HUMAN)
VARIDT ID
DTD0390
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms HsSWEET1; RAG1-activating protein 1; RAG1AP1; SCP; SLC50A1; SWEET1; Solute carrier family 50 member 1; Stromal cell protein; slv
DTP Family Sweet, Pq-loop, Saliva, Mtn3 (SWEET) family ;
Tissue Specificity Ubiquitously expressed with highest expressionin oviduct, epididymis and intestine.
Sequence
MEAGGFLDSLIYGACVVFTLGMFSAGLSDLRHMRMTRSVDNVQFLPFLTTEVNNLGWLSY
GALKGDGILIVVNTVGAALQTLYILAYLHYCPRKRVVLLQTATLLGVLLLGYGYFWLLVP
NPEARLQQLGLFCSVFTISMYLSPLADLAKVIQTKSTQCLSYPLTIATLLTSASWCLYGF
RLRDPYIMVSNFPGIVTSFIRFWLFWKYPQEQDRNYWLLQT
Function This transporter mediates sugar transport across membranes.
Endogenous Substrate(s) Sugars
TCDB ID
2.A.123.1.4
Gene ID
55974
Reactome Pathway
Cellular hexose transport (R-HSA-189200 )

Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 9.47E-50 4.93E-01 2.00E+00
Adrenocortical carcinoma 2D11.Z Kidney 2.41E-01 -3.23E-01 -5.65E-01
Alopecia ED70 Skin from scalp 6.63E-01 -3.15E-02 -8.39E-02
Alzheimer's disease 8A20 Entorhinal cortex 1.27E-01 6.84E-02 3.87E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 2.62E-01 1.65E-01 7.28E-01
Aortic stenosis BB70 Calcified aortic valve 2.81E-01 6.94E-02 1.63E-01
Apnea 7A40 Hyperplastic tonsil 7.71E-01 -9.21E-02 -5.05E-01
Arthropathy FA00-FA5Z Peripheral blood 1.25E-01 -2.96E-02 -2.37E-01
Asthma CA23 Nasal and bronchial airway 1.99E-02 3.04E-01 6.33E-01
Atopic dermatitis EA80 Skin 1.26E-02 2.60E-01 9.69E-01
Autism 6A02 Whole blood 9.78E-02 -1.34E-01 -6.22E-01
Autoimmune uveitis 9A96 Peripheral monocyte 4.82E-01 -1.22E-01 -8.02E-01
Autosomal dominant monocytopenia 4B04 Whole blood 1.51E-01 9.61E-02 6.04E-01
Bacterial infection of gingival 1C1H Gingival tissue 4.14E-15 3.35E-01 1.38E+00
Batten disease 5C56.1 Whole blood 7.73E-01 -9.94E-02 -7.32E-01
Behcet's disease 4A62 Peripheral blood 2.42E-01 -4.83E-02 -2.13E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 3.59E-01 -4.21E-03 -2.37E-02
Bladder cancer 2C94 Bladder tissue 3.80E-02 1.27E-01 6.78E-01
Breast cancer 2C60-2C6Z Breast tissue 5.07E-110 1.19E+00 2.33E+00
Cardioembolic stroke 8B11.20 Whole blood 3.65E-15 -5.55E-01 -3.17E+00
Cervical cancer 2C77 Cervical tissue 1.97E-09 2.20E-01 1.40E+00
Childhood onset rheumatic disease FA20.Z Peripheral blood 3.92E-01 1.30E-01 2.50E-01
Chronic hepatitis C 1E51.1 Whole blood 7.41E-01 -3.40E-02 -2.41E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 6.56E-01 -5.82E-02 -1.51E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 2.59E-01 1.14E-01 3.62E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 2.98E-02 2.33E-01 1.32E+00
Colon cancer 2B90 Colon tissue 3.64E-43 -5.24E-01 -1.65E+00
Coronary artery disease BA80-BA8Z Peripheral blood 4.28E-02 4.22E-01 1.59E+00
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 8.10E-01 2.06E-02 7.92E-02
Endometriosis GA10 Endometrium tissue 3.87E-01 -1.33E-01 -3.23E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 9.30E-01 5.46E-02 3.45E-01
Familial hypercholesterolemia 5C80.00 Whole blood 2.44E-03 2.62E-01 1.00E+00
Gastric cancer 2B72 Gastric tissue 3.11E-01 6.22E-01 8.74E-01
Glioblastopma 2A00.00 Nervous tissue 4.16E-01 -5.30E-04 -1.63E-03
Glioma 2A00.0Y-2A00.0Z White matter tissue 2.46E-01 -5.28E-02 -1.10E-01
Head and neck cancer 2D42 Head and neck tissue 2.82E-02 6.63E-02 2.64E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 8.61E-01 -1.17E-02 -7.98E-02
Huntington's disease 8A01.10 Whole blood 4.26E-01 1.37E-03 7.29E-03
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 7.76E-01 -8.45E-02 -2.44E-01
Immunodeficiency 4A00-4A20 Peripheral blood 9.05E-02 1.11E-01 9.99E-01
Influenza 1.00E+30 Whole blood 8.72E-01 5.03E-02 1.33E-01
Interstitial cystitis GC00.3 Bladder tissue 2.15E-01 1.62E-01 1.52E+00
Intracranial aneurysm 8B01.0 Intracranial artery 6.77E-04 2.90E-01 9.94E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 7.26E-02 -1.55E-01 -2.96E-01
Ischemic stroke 8B11 Peripheral blood 5.63E-01 9.70E-03 7.11E-02
Juvenile idiopathic arthritis FA24 Peripheral blood 5.45E-04 -1.97E-01 -5.39E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 8.23E-01 8.27E-02 3.70E-01
Lateral sclerosis 8B60.4 Skin 2.45E-01 4.23E-02 4.51E-01
Liver cancer 2C12.0 Liver tissue 9.59E-07 4.93E-01 8.60E-01
Liver failure DB99.7-DB99.8 Liver tissue 3.37E-01 1.39E-01 4.91E-01
Lung cancer 2C25 Lung tissue 6.22E-81 8.82E-01 2.82E+00
Lupus erythematosus 4A40 Whole blood 6.56E-03 2.39E-01 3.07E-01
Major depressive disorder 6A70-6A7Z Whole blood 1.01E-01 -4.33E-02 -2.42E-01
Major depressive disorder 6A70-6A7Z Hippocampus 2.01E-01 8.03E-02 4.19E-01
Melanoma 2C30 Skin 6.81E-02 -5.63E-01 -5.78E-01
Multiple myeloma 2A83.1 Bone marrow 2.64E-01 6.64E-02 3.44E-01
Multiple myeloma 2A83.1 Peripheral blood 8.35E-01 -1.08E-01 -6.06E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 3.03E-01 -1.00E-01 -4.52E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 6.16E-01 -1.38E-02 -5.88E-02
Myelofibrosis 2A20.2 Whole blood 1.90E-02 2.69E-01 2.96E+00
Myocardial infarction BA41-BA50 Peripheral blood 1.33E-02 -4.13E-01 -5.09E-01
Myopathy 8C70.6 Muscle tissue 2.71E-01 1.94E-01 6.36E-01
Neonatal sepsis KA60 Whole blood 2.38E-02 3.71E-02 1.26E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 2.44E-02 -3.37E-01 -1.48E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 3.56E-01 -1.09E-01 -4.55E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 2.64E-01 -1.83E-03 -2.44E-02
Olive pollen allergy CA08.00 Peripheral blood 6.61E-02 1.70E-01 1.10E+00
Oral cancer 2B6E Oral tissue 4.26E-01 1.89E-01 4.99E-01
Osteoarthritis FA00-FA0Z Synovial tissue 5.15E-01 -6.36E-02 -8.92E-02
Osteoporosis FB83.1 Bone marrow 3.94E-01 -7.48E-02 -2.56E-01
Ovarian cancer 2C73 Ovarian tissue 2.10E-04 1.45E+00 2.52E+00
Pancreatic cancer 2C10 Pancreas 1.09E-01 4.22E-01 6.80E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 9.55E-01 9.27E-03 3.89E-02
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 3.52E-01 -1.01E-01 -7.79E-01
Pituitary cancer 2D12 Pituitary tissue 9.51E-01 6.62E-02 1.98E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 1.20E-01 -3.97E-02 -1.21E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 8.48E-01 0.00E+00 0.00E+00
Polycythemia vera 2A20.4 Whole blood 5.47E-02 6.04E-02 5.11E-01
Pompe disease 5C51.3 Biceps muscle 7.76E-04 4.87E-01 1.83E+00
Preterm birth KA21.4Z Myometrium 4.63E-01 -2.50E-01 -8.18E-01
Prostate cancer 2C82 Prostate 4.74E-03 5.06E-01 7.54E-01
Psoriasis EA90 Skin 9.13E-07 1.89E-01 5.64E-01
Rectal cancer 2B92 Rectal colon tissue 1.62E-03 -4.52E-01 -1.74E+00
Renal cancer 2C90-2C91 Kidney 1.96E-01 -5.19E-02 -1.36E-01
Retinoblastoma 2D02.2 Uvea 1.27E-09 1.47E+00 8.02E+00
Rheumatoid arthritis FA20 Synovial tissue 3.49E-01 2.21E-01 3.69E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 1.96E-01 6.26E-02 4.92E-01
Schizophrenia 6A20 Prefrontal cortex 6.23E-02 1.47E-01 2.44E-01
Schizophrenia 6A20 Superior temporal cortex 9.77E-01 6.86E-02 4.06E-01
Scleroderma 4A42.Z Whole blood 6.08E-01 -2.62E-02 -1.57E-01
Seizure 8A60-8A6Z Whole blood 3.32E-01 1.86E-01 6.37E-01
Sensitive skin EK0Z Skin 7.42E-01 2.51E-01 1.25E+00
Sepsis with septic shock 1G41 Whole blood 3.94E-02 -1.21E-01 -4.05E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 1.49E-02 -2.93E-01 -1.65E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 2.70E-02 2.15E-01 7.41E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 9.92E-01 6.29E-02 1.17E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 8.71E-02 -7.06E-01 -1.61E+00
Skin cancer 2C30-2C3Z Skin 2.47E-03 1.32E-01 2.44E-01
Thrombocythemia 3B63 Whole blood 5.42E-01 4.19E-02 3.90E-01
Thrombocytopenia 3B64 Whole blood 2.67E-01 3.15E-01 7.31E-01
Thyroid cancer 2D10 Thyroid 2.39E-01 1.83E-02 8.01E-02
Tibial muscular dystrophy 8C75 Muscle tissue 6.50E-05 4.13E-01 1.83E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 6.85E-01 3.13E-02 2.85E-01
Type 2 diabetes 5A11 Liver tissue 4.53E-02 -1.83E-01 -1.50E+00
Ureter cancer 2C92 Urothelium 2.82E-01 1.53E-01 4.87E-01
Uterine cancer 2C78 Endometrium tissue 5.56E-01 -4.90E-02 -7.49E-02
Vitiligo ED63.0 Skin 5.66E-01 -1.40E-01 -5.03E-01
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