Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTJ5CF0)

DTP Name UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter (SLC35D1)
Gene Name SLC35D1
UniProt ID
Q9NTN3 (S35D1_HUMAN)
VARIDT ID
DTD0298
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms KIAA0260; SHNKND; SLC35D1; Solute carrier family 35 member D1; UDP-GlcA/UDP-GalNAc transporter; UDP-galactose transporter-related protein 7; UGTrel7
DTP Family Drug/Metabolite Transporter (DMT) Superfamily
UDP-glucuronate/UDP-N-acetylgalactosamine Transporter (UGnT) Family
Tissue Specificity Ubiquitous.
Sequence
MAEVHRRQHARVKGEAPAKSSTLRDEEELGMASAETLTVFLKLLAAGFYGVSSFLIVVVN
KSVLTNYRFPSSLCVGLGQMVATVAVLWVGKALRVVKFPDLDRNVPRKTFPLPLLYFGNQ
ITGLFSTKKLNLPMFTVLRRFSILFTMFAEGVLLKKTFSWGIKMTVFAMIIGAFVAASSD
LAFDLEGYAFILINDVLTAANGAYVKQKLDSKELGKYGLLYYNALFMILPTLAIAYFTGD
AQKAVEFEGWADTLFLLQFTLSCVMGFILMYATVLCTQYNSALTTTIVGCIKNILITYIG
MVFGGDYIFTWTNFIGLNISIAGSLVYSYITFTEEQLSKQSEANNKLDIKGKGAV
Function
This transporter transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm into the endoplasmic reticulum lumen. It also plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development.
Endogenous Substrate(s) UDP-glucuronate; UDP-N-acetylgalactosamine
TCDB ID
2.A.7.15.4
Gene ID
23169
Reactome Pathway
Defective SLC35D1 causes SCHBCKD (R-HSA-5579020 )
Transport of nucleotide sugars (R-HSA-727802 )
Formation of the active cofactor, UDP-glucuronate (R-HSA-173599 )

Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 5.00E-06 2.32E-01 4.67E-01
Adrenocortical carcinoma 2D11.Z Kidney 4.31E-01 2.79E-02 8.45E-02
Alopecia ED70 Skin from scalp 9.45E-02 -1.14E-01 -3.03E-01
Alzheimer's disease 8A20 Entorhinal cortex 5.85E-01 -3.16E-02 -1.18E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 9.94E-01 -1.29E-02 -7.70E-02
Aortic stenosis BB70 Calcified aortic valve 9.51E-01 -6.01E-02 -7.01E-02
Apnea 7A40 Hyperplastic tonsil 5.21E-01 1.61E-02 2.13E-02
Arthropathy FA00-FA5Z Peripheral blood 1.67E-01 -2.78E-01 -8.31E-01
Asthma CA23 Nasal and bronchial airway 7.25E-01 -7.67E-02 -1.02E-01
Atopic dermatitis EA80 Skin 4.17E-01 7.96E-02 3.37E-01
Autism 6A02 Whole blood 6.96E-01 -7.21E-02 -2.01E-01
Autoimmune uveitis 9A96 Peripheral monocyte 2.84E-01 3.31E-01 1.01E+00
Autosomal dominant monocytopenia 4B04 Whole blood 2.61E-01 7.22E-02 1.39E-01
Bacterial infection of gingival 1C1H Gingival tissue 1.25E-01 5.81E-02 1.70E-01
Batten disease 5C56.1 Whole blood 7.39E-01 -1.05E-01 -3.50E-01
Behcet's disease 4A62 Peripheral blood 3.63E-01 -5.42E-02 -1.28E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 2.78E-02 7.42E-02 4.68E-01
Bladder cancer 2C94 Bladder tissue 7.08E-03 -4.79E-01 -1.44E+00
Breast cancer 2C60-2C6Z Breast tissue 5.92E-05 1.97E-01 3.58E-01
Cardioembolic stroke 8B11.20 Whole blood 7.57E-02 2.05E-01 9.62E-01
Cervical cancer 2C77 Cervical tissue 3.77E-02 -2.21E-01 -5.29E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 7.62E-01 -1.03E-01 -1.40E-01
Chronic hepatitis C 1E51.1 Whole blood 7.65E-01 -1.43E-01 -2.53E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 9.80E-01 -6.21E-02 -1.60E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 2.79E-05 -3.82E-01 -1.02E+00
Chronic rhinosinusitis CA0A Sinus mucosa tissue 6.94E-01 -1.71E-02 -9.02E-02
Colon cancer 2B90 Colon tissue 1.71E-95 -1.33E+00 -3.16E+00
Coronary artery disease BA80-BA8Z Peripheral blood 1.71E-01 3.67E-02 3.08E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 1.77E-01 -4.34E-01 -1.36E+00
Endometriosis GA10 Endometrium tissue 3.98E-01 1.89E-01 3.18E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 9.15E-01 1.06E-01 5.45E-01
Familial hypercholesterolemia 5C80.00 Whole blood 2.58E-02 -1.45E-01 -4.84E-01
Gastric cancer 2B72 Gastric tissue 5.26E-01 -9.50E-03 -8.72E-02
Glioblastopma 2A00.00 Nervous tissue 4.76E-63 5.25E-01 1.19E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 1.63E-03 4.31E-01 1.16E+00
Head and neck cancer 2D42 Head and neck tissue 1.18E-17 4.89E-01 1.29E+00
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 4.54E-01 1.45E-01 3.41E-01
Huntington's disease 8A01.10 Whole blood 9.99E-01 6.57E-03 2.30E-02
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 3.15E-01 9.20E-02 8.81E-01
Immunodeficiency 4A00-4A20 Peripheral blood 5.80E-01 4.58E-02 4.72E-01
Influenza 1.00E+30 Whole blood 3.11E-02 -1.11E+00 -2.53E+00
Interstitial cystitis GC00.3 Bladder tissue 6.55E-05 -5.92E-01 -3.77E+00
Intracranial aneurysm 8B01.0 Intracranial artery 2.35E-01 1.27E-01 3.41E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 1.32E-01 -1.11E-01 -3.82E-01
Ischemic stroke 8B11 Peripheral blood 5.72E-01 -3.69E-02 -1.20E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 4.02E-02 3.09E-02 3.92E-02
Lateral sclerosis 8B60.4 Cervical spinal cord 1.12E-02 2.62E-01 1.32E+00
Lateral sclerosis 8B60.4 Skin 1.41E-01 2.69E-01 1.35E+00
Liver cancer 2C12.0 Liver tissue 2.30E-17 -8.15E-01 -1.76E+00
Liver failure DB99.7-DB99.8 Liver tissue 1.65E-05 -2.55E+00 -1.40E+01
Lung cancer 2C25 Lung tissue 2.21E-71 6.94E-01 2.18E+00
Lupus erythematosus 4A40 Whole blood 2.35E-09 -2.84E-01 -7.55E-01
Major depressive disorder 6A70-6A7Z Whole blood 5.70E-03 -1.36E-01 -4.81E-01
Major depressive disorder 6A70-6A7Z Hippocampus 1.80E-01 -1.20E-01 -7.29E-01
Melanoma 2C30 Skin 6.11E-01 -1.28E-01 -2.09E-01
Multiple myeloma 2A83.1 Bone marrow 3.35E-04 5.05E-01 2.40E+00
Multiple myeloma 2A83.1 Peripheral blood 8.54E-01 4.14E-02 2.54E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 8.56E-01 -2.17E-02 -6.44E-02
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 6.55E-06 -7.17E-01 -9.49E-01
Myelofibrosis 2A20.2 Whole blood 2.00E-05 -3.31E-01 -1.57E+00
Myocardial infarction BA41-BA50 Peripheral blood 1.16E-01 -3.25E-01 -4.88E-01
Myopathy 8C70.6 Muscle tissue 6.36E-01 -1.87E-02 -7.12E-02
Neonatal sepsis KA60 Whole blood 9.89E-12 -5.78E-01 -9.80E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 4.57E-13 7.37E-01 5.06E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 7.14E-01 3.08E-02 1.57E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 2.27E-01 -1.10E-01 -6.97E-01
Olive pollen allergy CA08.00 Peripheral blood 5.04E-01 -4.70E-01 -4.85E-01
Oral cancer 2B6E Oral tissue 1.51E-03 5.03E-01 8.87E-01
Osteoarthritis FA00-FA0Z Synovial tissue 1.53E-01 8.54E-01 7.37E-01
Osteoporosis FB83.1 Bone marrow 7.21E-01 7.52E-02 1.49E-01
Ovarian cancer 2C73 Ovarian tissue 2.75E-01 1.73E-01 3.79E-01
Pancreatic cancer 2C10 Pancreas 4.75E-02 2.62E-01 3.62E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 1.43E-02 2.26E-01 9.62E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 1.65E-02 -7.61E-02 -3.15E-01
Pituitary cancer 2D12 Pituitary tissue 2.90E-06 -1.00E+00 -2.71E+00
Pituitary gonadotrope tumour 2D12 Pituitary tissue 6.49E-03 -4.46E-01 -1.22E+00
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 9.83E-01 1.19E-02 4.36E-02
Polycythemia vera 2A20.4 Whole blood 4.31E-07 -2.78E-01 -1.01E+00
Pompe disease 5C51.3 Biceps muscle 7.40E-03 -7.67E-01 -2.08E+00
Preterm birth KA21.4Z Myometrium 5.61E-01 -1.07E-01 -2.41E-01
Prostate cancer 2C82 Prostate 3.60E-02 -2.76E-01 -6.14E-01
Psoriasis EA90 Skin 9.80E-01 3.70E-02 7.48E-02
Rectal cancer 2B92 Rectal colon tissue 5.39E-03 -6.34E-01 -1.85E+00
Renal cancer 2C90-2C91 Kidney 3.76E-01 1.21E-01 5.47E-01
Retinoblastoma 2D02.2 Uvea 5.66E-03 5.46E-01 1.62E+00
Rheumatoid arthritis FA20 Synovial tissue 1.46E-05 9.51E-01 3.67E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 1.13E-01 -2.05E-02 -1.25E-01
Schizophrenia 6A20 Prefrontal cortex 5.28E-01 -5.91E-02 -1.00E-01
Schizophrenia 6A20 Superior temporal cortex 6.47E-01 2.73E-02 1.64E-01
Scleroderma 4A42.Z Whole blood 3.79E-01 8.48E-02 3.10E-01
Seizure 8A60-8A6Z Whole blood 7.17E-01 1.26E-01 2.23E-01
Sensitive skin EK0Z Skin 5.25E-01 -1.09E-02 -9.03E-02
Sepsis with septic shock 1G41 Whole blood 2.39E-29 -5.53E-01 -1.14E+00
Shwachman-Diamond syndrome 3A70.0 Bone marrow 1.51E-01 -2.47E-01 -1.47E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 7.82E-02 -3.47E-01 -5.42E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 1.08E-01 -6.44E-01 -1.96E+00
Sjogren's syndrome 4A43.2 Salivary gland tissue 9.33E-02 3.03E-01 1.03E+00
Skin cancer 2C30-2C3Z Skin 9.35E-01 -8.73E-03 -1.88E-02
Thrombocythemia 3B63 Whole blood 9.06E-06 -1.91E-01 -9.05E-01
Thrombocytopenia 3B64 Whole blood 3.30E-01 -1.02E+00 -8.49E-01
Thyroid cancer 2D10 Thyroid 3.92E-02 -1.62E-01 -5.75E-01
Tibial muscular dystrophy 8C75 Muscle tissue 1.94E-02 -3.99E-01 -1.05E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 5.94E-01 -7.88E-02 -2.69E-01
Type 2 diabetes 5A11 Liver tissue 7.67E-01 2.24E-01 4.25E-01
Ureter cancer 2C92 Urothelium 9.36E-01 7.62E-02 1.97E-01
Uterine cancer 2C78 Endometrium tissue 2.87E-03 -8.19E-02 -1.58E-01
Vitiligo ED63.0 Skin 4.67E-01 1.95E-01 2.78E-01
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