Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTKM9DZ)

DTP Name Adrenoleukodystrophy protein (ABCD1)
Gene Name ABCD1
UniProt ID
P33897 (ABCD1_HUMAN)
VARIDT ID
DTD0063
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms ABC42; ABCD1 ALD; ALD; ALDP; AMN; ATP-binding cassette sub-family D member 1; Adrenoleukodystrophy protein
DTP Family ATP-Binding Cassette (ABC) Superfamily ;
Sequence
MPVLSRPRPWRGNTLKRTAVLLALAAYGAHKVYPLVRQCLAPARGLQAPAGEPTQEASGV
AAAKAGMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLAR
CIVRKDPRAFGWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQTY
YRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGT
AWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHE
VELALLQRSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYSES
DAEAVKKAALEKKEEELVSERTEAFTIARNLLTAAADAIERIMSSYKEVTELAGYTARVH
EMFQVFEDVQRCHFKRPRELEDAQAGSGTIGRSGVRVEGPLKIRGQVVDVEQGIICENIP
IVTPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQRMF
YIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAMCD
WKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHR
PSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAGIPKMQRRLQELCQIL
GEAVAPAHVPAPSPQGPGGLQGAST
Function
This transporter plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis.
Endogenous Substrate(s) Long-chain fatty acids
TCDB ID
3.A.1.203.3
Gene ID
215
KEGG Pathway
ABC transporters (hsa02010 )
Peroxisome (hsa04146 )
Reactome Pathway
Linoleic acid (LA) metabolism (R-HSA-2046105 )
alpha-linolenic acid (ALA) metabolism (R-HSA-2046106 )
Beta-oxidation of very long chain fatty acids (R-HSA-390247 )
Defective ABCD1 causes ALD (R-HSA-5684045 )
Class I peroxisomal membrane protein import (R-HSA-9603798 )
ABC transporters in lipid homeostasis (R-HSA-1369062 )

Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 9.62E-10 2.06E-01 5.36E-01
Adrenocortical carcinoma 2D11.Z Kidney 5.00E-01 3.07E-01 6.85E-01
Alopecia ED70 Skin from scalp 5.14E-03 -2.70E-01 -5.29E-01
Alzheimer's disease 8A20 Entorhinal cortex 4.51E-01 -1.42E-02 -7.82E-02
Ankylosing spondylitis FA92.0 Pheripheral blood 4.12E-01 1.38E-01 5.25E-01
Aortic stenosis BB70 Calcified aortic valve 5.39E-01 1.06E-01 2.38E-01
Apnea 7A40 Hyperplastic tonsil 2.55E-01 -8.74E-02 -3.83E-01
Arthropathy FA00-FA5Z Peripheral blood 3.80E-01 2.47E-02 9.28E-02
Asthma CA23 Nasal and bronchial airway 7.50E-03 1.15E-01 3.17E-01
Atopic dermatitis EA80 Skin 8.36E-03 1.47E-01 6.95E-01
Autism 6A02 Whole blood 5.71E-01 1.95E-02 6.90E-02
Autoimmune uveitis 9A96 Peripheral monocyte 7.87E-01 1.96E-02 9.49E-02
Autosomal dominant monocytopenia 4B04 Whole blood 2.75E-01 -2.91E-01 -6.54E-01
Bacterial infection of gingival 1C1H Gingival tissue 6.62E-05 3.05E-01 7.05E-01
Batten disease 5C56.1 Whole blood 1.38E-01 1.63E-01 9.12E-01
Behcet's disease 4A62 Peripheral blood 9.98E-01 -8.69E-02 -2.69E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 6.76E-01 -1.18E-01 -5.22E-01
Bladder cancer 2C94 Bladder tissue 3.76E-02 3.77E-01 8.65E-01
Breast cancer 2C60-2C6Z Breast tissue 1.65E-07 1.32E-01 2.74E-01
Cardioembolic stroke 8B11.20 Whole blood 8.57E-16 6.29E-01 3.12E+00
Cervical cancer 2C77 Cervical tissue 1.59E-01 8.44E-02 3.07E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 5.28E-01 1.43E-01 3.32E-01
Chronic hepatitis C 1E51.1 Whole blood 5.64E-01 -2.25E-02 -9.50E-02
Chronic obstructive pulmonary disease CA22 Lung tissue 9.21E-01 -2.55E-02 -9.36E-02
Chronic obstructive pulmonary disease CA22 Small airway epithelium 2.46E-01 -4.79E-02 -1.28E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 4.40E-02 2.36E-01 7.55E-01
Colon cancer 2B90 Colon tissue 3.74E-07 -1.86E-01 -5.61E-01
Coronary artery disease BA80-BA8Z Peripheral blood 1.15E-01 -2.25E-01 -1.00E+00
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 5.85E-01 -3.35E-03 -3.55E-02
Endometriosis GA10 Endometrium tissue 9.90E-02 -8.66E-02 -2.22E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 1.16E-01 1.68E-01 7.28E-01
Familial hypercholesterolemia 5C80.00 Whole blood 4.58E-13 7.95E-01 2.28E+00
Gastric cancer 2B72 Gastric tissue 9.06E-01 8.66E-02 3.02E-01
Glioblastopma 2A00.00 Nervous tissue 4.84E-02 1.64E-02 4.78E-02
Glioma 2A00.0Y-2A00.0Z White matter tissue 4.72E-01 9.23E-02 2.54E-01
Head and neck cancer 2D42 Head and neck tissue 1.66E-06 1.85E-01 6.80E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 9.83E-01 4.36E-02 2.02E-01
Huntington's disease 8A01.10 Whole blood 1.77E-01 2.60E-01 8.85E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 6.51E-03 2.50E-01 1.31E+00
Immunodeficiency 4A00-4A20 Peripheral blood 2.54E-03 2.37E-01 1.43E+00
Influenza 1.00E+30 Whole blood 1.19E-02 8.74E-01 2.90E+00
Interstitial cystitis GC00.3 Bladder tissue 8.17E-01 1.76E-01 4.08E-01
Intracranial aneurysm 8B01.0 Intracranial artery 2.32E-01 -1.19E-01 -2.20E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 8.50E-01 -3.09E-02 -1.51E-01
Ischemic stroke 8B11 Peripheral blood 9.31E-01 2.18E-02 6.15E-02
Juvenile idiopathic arthritis FA24 Peripheral blood 9.06E-01 2.93E-02 6.35E-02
Lateral sclerosis 8B60.4 Cervical spinal cord 4.48E-02 -1.66E-01 -6.38E-01
Lateral sclerosis 8B60.4 Skin 7.68E-01 -3.96E-02 -1.17E-01
Liver cancer 2C12.0 Liver tissue 2.46E-03 9.86E-02 2.57E-01
Liver failure DB99.7-DB99.8 Liver tissue 1.80E-04 5.83E-01 2.40E+00
Lung cancer 2C25 Lung tissue 5.13E-02 -5.36E-02 -1.53E-01
Lupus erythematosus 4A40 Whole blood 2.23E-01 5.12E-02 1.57E-01
Major depressive disorder 6A70-6A7Z Whole blood 2.38E-01 7.84E-02 2.22E-01
Major depressive disorder 6A70-6A7Z Hippocampus 8.77E-01 -3.18E-02 -1.32E-01
Melanoma 2C30 Skin 3.90E-04 7.43E-01 8.37E-01
Multiple myeloma 2A83.1 Bone marrow 2.66E-02 -1.87E-01 -8.32E-01
Multiple myeloma 2A83.1 Peripheral blood 8.74E-01 3.22E-02 1.10E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 7.11E-01 -3.24E-02 -1.29E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 6.87E-01 -3.05E-02 -1.58E-01
Myelofibrosis 2A20.2 Whole blood 3.29E-02 -1.25E-01 -8.05E-01
Myocardial infarction BA41-BA50 Peripheral blood 7.57E-01 -1.75E-01 -3.13E-01
Myopathy 8C70.6 Muscle tissue 6.49E-01 -1.14E-02 -3.72E-02
Neonatal sepsis KA60 Whole blood 2.74E-10 2.64E-01 7.40E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 1.18E-03 -8.01E-01 -1.63E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 9.27E-01 -1.21E-02 -5.65E-02
Obesity related type 2 diabetes 5A11 Omental adipose tissue 2.98E-02 2.10E-01 1.01E+00
Olive pollen allergy CA08.00 Peripheral blood 5.00E-01 2.75E-01 7.64E-01
Oral cancer 2B6E Oral tissue 3.12E-02 -1.45E-01 -5.48E-01
Osteoarthritis FA00-FA0Z Synovial tissue 5.92E-01 -1.61E-02 -2.99E-02
Osteoporosis FB83.1 Bone marrow 8.45E-03 8.85E-01 2.73E+00
Ovarian cancer 2C73 Ovarian tissue 7.78E-02 3.23E-01 8.89E-01
Pancreatic cancer 2C10 Pancreas 4.21E-01 -1.25E-01 -2.49E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 6.38E-01 6.30E-02 1.96E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 1.11E-01 7.17E-02 3.29E-01
Pituitary cancer 2D12 Pituitary tissue 5.31E-01 1.34E-01 3.90E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 3.14E-01 5.97E-02 2.14E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 6.90E-01 -4.86E-03 -3.86E-02
Polycythemia vera 2A20.4 Whole blood 4.96E-05 -1.42E-01 -8.89E-01
Pompe disease 5C51.3 Biceps muscle 6.51E-01 2.39E-02 1.10E-01
Preterm birth KA21.4Z Myometrium 7.49E-03 2.04E-01 2.01E+00
Prostate cancer 2C82 Prostate 3.53E-05 -6.83E-01 -1.30E+00
Psoriasis EA90 Skin 2.80E-08 -3.29E-01 -6.86E-01
Rectal cancer 2B92 Rectal colon tissue 6.37E-01 1.36E-02 7.98E-02
Renal cancer 2C90-2C91 Kidney 1.14E-01 -3.90E-01 -1.18E+00
Retinoblastoma 2D02.2 Uvea 2.17E-05 1.41E+00 6.93E+00
Rheumatoid arthritis FA20 Synovial tissue 5.31E-04 6.75E-01 2.46E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 1.12E-02 4.31E-02 3.60E-01
Schizophrenia 6A20 Prefrontal cortex 9.71E-02 1.87E-01 4.31E-01
Schizophrenia 6A20 Superior temporal cortex 9.92E-01 -2.07E-02 -1.15E-01
Scleroderma 4A42.Z Whole blood 6.17E-06 4.69E-01 3.23E+00
Seizure 8A60-8A6Z Whole blood 9.55E-01 2.14E-02 7.02E-02
Sensitive skin EK0Z Skin 4.12E-01 2.24E-02 1.19E-01
Sepsis with septic shock 1G41 Whole blood 8.55E-29 3.47E-01 1.23E+00
Shwachman-Diamond syndrome 3A70.0 Bone marrow 4.06E-01 -1.74E-01 -6.88E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 3.15E-01 1.45E-01 3.73E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 3.02E-01 3.53E-02 1.27E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 4.30E-01 3.93E-01 9.90E-01
Skin cancer 2C30-2C3Z Skin 1.12E-15 3.77E-01 7.40E-01
Thrombocythemia 3B63 Whole blood 6.53E-03 -1.56E-01 -9.75E-01
Thrombocytopenia 3B64 Whole blood 5.45E-01 6.57E-01 7.05E-01
Thyroid cancer 2D10 Thyroid 1.87E-02 4.85E-02 1.72E-01
Tibial muscular dystrophy 8C75 Muscle tissue 6.81E-02 -6.76E-02 -1.45E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 1.95E-01 1.29E-01 4.90E-01
Type 2 diabetes 5A11 Liver tissue 2.26E-01 -3.67E-01 -8.63E-01
Ureter cancer 2C92 Urothelium 2.59E-01 -1.27E-01 -6.09E-01
Uterine cancer 2C78 Endometrium tissue 2.70E-01 -8.41E-02 -1.71E-01
Vitiligo ED63.0 Skin 8.81E-01 -5.67E-02 -3.13E-01
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