Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTMSNOU)

DTP Name Proton-associated sugar transporter A (SLC45A1)
Gene Name SLC45A1
UniProt ID
Q9Y2W3 (S45A1_HUMAN)
VARIDT ID
DTD0368
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Synonyms DNB5; DNb-5; Deleted in neuroblastoma 5 protein; IDDNPF; PAST-A; SLC45A1; Solute carrier family 45 member 1
DTP Family Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family ;
Tissue Specificity Expressed in adult heart, brain, muscle andkidney, with very strong expression in brain. Also expressed infetal brain, kidney and lung.
Sequence
MLQQPGPRPGRQQPSGDRDACRLHPQGRPPALPTMIPAASSTPPGDALFPSVAPQDFWRS
QVTGYSGSVTRHLSHRANNFKRHPKRRKCIRPSPPPPPNTPCPLELVDFGDLHPQRSFRE
LLFNGCILFGIEFSYAMETAYVTPVLLQMGLPDQLYSLVWFISPILGFLLQPLLGAWSDR
CTSRFGRRRPFILVLAIGALLGLSLLLNGRDIGIALADVTGNHKWGLLLTVCGVVLMDFS
ADSADNPSHAYMMDVCSPADQDRGLNIHALLAGLGGGFGYVVGGIHWDKTGFGRALGGQL
RVIYLFTAVTLSVTTVLTLVSIPERPLRPPSEKRAAMKSPSLPLPPSPPVLPEEGPGDSL
PSHTATNFSSPISPPSPLTPKYGSFISRDSSLTGISEFASSFGTANIDSVLIDCFTGGHD
SYLAIPGSVPRPPISVSFPRAPDGFYRQDRGLLEGREGALTSGCDGDILRVGSLDTSKPR
SSGILKRPQTLAIPDAAGGGGPETSRRRNVTFSQQVANILLNGVKYESELTGSSERAEQP
LSVGRLCSTICNMPKALRTLCVNHFLGWLSFEGMLLFYTDFMGEVVFQGDPKAPHTSEAY
QKYNSGVTMGCWGMCIYAFSAAFYSAILEKLEEFLSVRTLYFIAYLAFGLGTGLATLSRN
LYVVLSLCITYGILFSTLCTLPYSLLCDYYQSKKFAGSSADGTRRGMGVDISLLSCQYFL
AQILVSLVLGPLTSAVGSANGVMYFSSLVSFLGCLYSSLFVIYEIPPSDAADEEHRPLLL
NV
Function This transporter mediates the transport of proton-associated glucose in the brain.
Endogenous Substrate(s) Glucose; Galactose; Sucrose
TCDB ID
2.A.2.4.10
Gene ID
50651

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
1 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [1]
------------------------------------------------------------------------------------

Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 1.10E-03 -9.38E-02 -3.30E-01
Adrenocortical carcinoma 2D11.Z Kidney 9.04E-01 -2.26E-01 -6.40E-01
Alopecia ED70 Skin from scalp 4.78E-01 2.16E-02 8.57E-02
Alzheimer's disease 8A20 Entorhinal cortex 3.38E-11 -3.55E-01 -1.03E+00
Ankylosing spondylitis FA92.0 Pheripheral blood 7.51E-01 -4.61E-02 -2.94E-01
Aortic stenosis BB70 Calcified aortic valve 2.29E-01 -4.91E-02 -1.75E-01
Apnea 7A40 Hyperplastic tonsil 7.93E-01 2.74E-03 1.17E-02
Arthropathy FA00-FA5Z Peripheral blood 6.32E-01 -2.34E-02 -1.71E-01
Asthma CA23 Nasal and bronchial airway 2.30E-01 4.02E-02 1.44E-01
Atopic dermatitis EA80 Skin 6.65E-01 3.74E-04 2.13E-03
Autism 6A02 Whole blood 3.00E-02 -1.02E-01 -3.71E-01
Autoimmune uveitis 9A96 Peripheral monocyte 1.05E-01 -1.66E-01 -7.89E-01
Autosomal dominant monocytopenia 4B04 Whole blood 9.23E-01 0.00E+00 0.00E+00
Bacterial infection of gingival 1C1H Gingival tissue 2.79E-01 4.41E-02 1.71E-01
Batten disease 5C56.1 Whole blood 8.37E-01 9.91E-02 1.09E+00
Behcet's disease 4A62 Peripheral blood 2.47E-01 1.35E-01 1.06E+00
Bipolar disorder 6A60-6A6Z Prefrontal cortex 3.91E-01 -6.16E-02 -2.41E-01
Bladder cancer 2C94 Bladder tissue 1.91E-01 -2.28E-01 -8.52E-01
Breast cancer 2C60-2C6Z Breast tissue 1.79E-13 -2.09E-01 -6.49E-01
Cardioembolic stroke 8B11.20 Whole blood 4.43E-01 4.93E-02 2.18E-01
Cervical cancer 2C77 Cervical tissue 8.48E-02 -9.82E-02 -3.62E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 8.53E-01 1.41E-01 4.84E-01
Chronic hepatitis C 1E51.1 Whole blood 8.58E-01 -3.03E-02 -2.15E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 2.73E-01 1.42E-02 8.77E-02
Chronic obstructive pulmonary disease CA22 Small airway epithelium 2.33E-01 6.84E-02 3.52E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 3.90E-01 3.35E-02 3.43E-01
Colon cancer 2B90 Colon tissue 3.02E-01 -2.48E-03 -1.06E-02
Coronary artery disease BA80-BA8Z Peripheral blood 9.60E-01 1.02E-02 4.84E-02
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 2.15E-01 -7.38E-02 -3.04E-01
Endometriosis GA10 Endometrium tissue 7.60E-01 -9.72E-02 -4.05E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 8.84E-01 -2.50E-02 -1.06E-01
Familial hypercholesterolemia 5C80.00 Whole blood 1.30E-01 -3.85E-01 -1.18E+00
Gastric cancer 2B72 Gastric tissue 7.80E-01 -9.02E-02 -3.92E-01
Glioblastopma 2A00.00 Nervous tissue 3.34E-103 -8.12E-01 -1.61E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 7.76E-01 -6.78E-02 -1.84E-01
Head and neck cancer 2D42 Head and neck tissue 6.50E-02 -4.05E-02 -1.85E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 9.89E-01 1.03E-02 3.09E-02
Huntington's disease 8A01.10 Whole blood 6.45E-01 -1.62E-02 -6.42E-02
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 5.37E-01 2.33E-02 1.96E-01
Immunodeficiency 4A00-4A20 Peripheral blood 8.61E-01 -8.61E-03 -9.16E-02
Influenza 1.00E+30 Whole blood 3.93E-01 1.86E-01 6.53E-01
Interstitial cystitis GC00.3 Bladder tissue 2.14E-01 1.69E-02 9.08E-02
Intracranial aneurysm 8B01.0 Intracranial artery 2.55E-01 1.00E-01 4.48E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 5.73E-01 -9.38E-03 -3.86E-02
Ischemic stroke 8B11 Peripheral blood 4.89E-02 7.19E-02 5.14E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 8.50E-01 -1.60E-02 -5.46E-02
Lateral sclerosis 8B60.4 Cervical spinal cord 6.65E-01 8.74E-02 9.69E-02
Lateral sclerosis 8B60.4 Skin 4.34E-01 7.38E-02 4.53E-01
Liver cancer 2C12.0 Liver tissue 2.05E-06 -1.82E-01 -9.05E-01
Liver failure DB99.7-DB99.8 Liver tissue 6.32E-02 -1.94E-01 -8.60E-01
Lung cancer 2C25 Lung tissue 3.62E-05 1.23E-02 5.29E-02
Lupus erythematosus 4A40 Whole blood 5.53E-03 -1.94E-01 -3.79E-01
Major depressive disorder 6A70-6A7Z Whole blood 8.90E-01 -2.47E-02 -9.68E-02
Major depressive disorder 6A70-6A7Z Hippocampus 7.02E-01 1.63E-02 7.52E-02
Melanoma 2C30 Skin 6.09E-02 -2.39E-01 -4.24E-01
Multiple myeloma 2A83.1 Bone marrow 9.65E-02 -1.77E-01 -9.29E-01
Multiple myeloma 2A83.1 Peripheral blood 2.83E-01 2.31E-02 1.20E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 5.80E-01 -1.98E-01 -5.30E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 3.79E-01 4.24E-03 3.31E-02
Myelofibrosis 2A20.2 Whole blood 4.16E-03 2.89E-01 1.50E+00
Myocardial infarction BA41-BA50 Peripheral blood 3.42E-02 2.05E-01 4.22E-01
Myopathy 8C70.6 Muscle tissue 2.27E-01 -2.09E-01 -1.09E+00
Neonatal sepsis KA60 Whole blood 3.15E-02 -7.11E-02 -2.32E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 3.51E-06 -5.20E-01 -2.38E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 8.49E-02 -1.28E-01 -1.01E+00
Obesity related type 2 diabetes 5A11 Omental adipose tissue 7.63E-01 1.27E-02 7.50E-02
Olive pollen allergy CA08.00 Peripheral blood 1.42E-01 2.35E-01 9.14E-01
Oral cancer 2B6E Oral tissue 5.81E-04 -1.83E-01 -5.39E-01
Osteoarthritis FA00-FA0Z Synovial tissue 9.03E-02 3.23E-01 9.30E-01
Osteoporosis FB83.1 Bone marrow 3.85E-01 9.44E-03 4.14E-02
Ovarian cancer 2C73 Ovarian tissue 1.15E-02 -3.16E-01 -1.08E+00
Pancreatic cancer 2C10 Pancreas 9.20E-03 -3.65E-01 -8.92E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 2.69E-01 -3.82E-01 -7.23E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 2.21E-01 2.64E-02 2.42E-01
Pituitary cancer 2D12 Pituitary tissue 1.83E-04 -4.30E-01 -1.79E+00
Pituitary gonadotrope tumour 2D12 Pituitary tissue 2.14E-03 -5.21E-01 -2.27E+00
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 5.61E-01 -3.95E-02 -1.63E-01
Polycythemia vera 2A20.4 Whole blood 6.74E-06 1.90E-01 9.63E-01
Pompe disease 5C51.3 Biceps muscle 4.78E-01 -1.31E-01 -5.06E-01
Preterm birth KA21.4Z Myometrium 3.30E-01 8.58E-02 2.69E-01
Prostate cancer 2C82 Prostate 5.66E-01 -1.82E-01 -3.20E-01
Psoriasis EA90 Skin 7.36E-15 -3.39E-01 -1.06E+00
Rectal cancer 2B92 Rectal colon tissue 9.62E-01 -2.08E-02 -1.26E-01
Renal cancer 2C90-2C91 Kidney 5.12E-03 -3.88E-01 -1.76E+00
Retinoblastoma 2D02.2 Uvea 4.01E-09 -1.75E+00 -4.41E+00
Rheumatoid arthritis FA20 Synovial tissue 1.89E-02 -3.60E-01 -8.39E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 6.28E-01 -9.32E-03 -7.05E-02
Schizophrenia 6A20 Prefrontal cortex 3.71E-02 -2.89E-01 -2.94E-01
Schizophrenia 6A20 Superior temporal cortex 6.36E-02 -1.16E-01 -5.36E-01
Scleroderma 4A42.Z Whole blood 6.37E-01 2.59E-02 1.66E-01
Seizure 8A60-8A6Z Whole blood 6.16E-01 -1.01E-02 -3.34E-02
Sensitive skin EK0Z Skin 2.46E-01 5.32E-02 4.95E-01
Sepsis with septic shock 1G41 Whole blood 2.85E-02 -4.06E-02 -1.42E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 1.25E-02 4.38E-01 1.74E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 1.75E-01 9.51E-02 5.55E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 9.26E-01 -5.14E-02 -2.16E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 9.07E-01 -2.31E-01 -1.16E+00
Skin cancer 2C30-2C3Z Skin 4.44E-20 -4.01E-01 -1.12E+00
Thrombocythemia 3B63 Whole blood 2.33E-02 2.34E-01 1.18E+00
Thrombocytopenia 3B64 Whole blood 4.28E-01 9.00E-02 1.62E-01
Thyroid cancer 2D10 Thyroid 2.69E-12 1.73E-01 8.53E-01
Tibial muscular dystrophy 8C75 Muscle tissue 7.91E-01 -3.70E-02 -1.57E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 1.41E-01 -3.68E-01 -4.54E+00
Type 2 diabetes 5A11 Liver tissue 3.42E-01 -6.91E-02 -2.59E-01
Ureter cancer 2C92 Urothelium 5.32E-01 -3.40E-02 -1.96E-01
Uterine cancer 2C78 Endometrium tissue 1.04E-21 -6.51E-01 -1.04E+00
Vitiligo ED63.0 Skin 2.62E-01 -7.09E-02 -2.29E-01
------------------------------------------------------------------------------------
⏷ Show the Full List of Expression Under 107 Diseases

References

1 Dysfunction of the Cerebral Glucose Transporter SLC45A1 in Individuals with Intellectual Disability and Epilepsy. Am J Hum Genet. 2017 May 4;100(5):824-830.