Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTNCJAT)

DTP Name Membrane-associated transporter protein (SLC45A2)
Gene Name SLC45A2
UniProt ID
Q9UMX9 (S45A2_HUMAN)
VARIDT ID
DTD0369
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms 1A1; AIM1; MATP; Melanoma antigen AIM1; OCA4; Protein AIM-1; SHEP5; SLC45A2; Solute carrier family 45 member 2
DTP Family Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family ;
Tissue Specificity Expressed in most melanoma cell lines andmelanocytes.
Sequence
MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVL
LSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGMALY
LNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGL
HYHALFTGFGGALGYLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLCFTVHLCSISEA
PLTEVAKGIPPQQTPQDPPLSSDGMYEYGSIEKVKNGYVNPELAMQGAKNKNHAEQTRRA
MTLKSLLRALVNMPPHYRYLCISHLIGWTAFLSNMLFFTDFMGQIVYRGDPYSAHNSTEF
LIYERGVEVGCWGLCINSVFSSLYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLFPN
VYSTLVLCSLFGVMSSTLYTVPFNLITEYHREEEKERQQAPGGDPDNSVRGKGMDCATLT
CMVQLAQILVGGGLGFLVNTAGTVVVVVITASAVALIGCCFVALFVRYVD
Function This tranporter may meditates the transport of substances required for melanin biosynthesis.
Endogenous Substrate(s) Sucrose
TCDB ID
2.A.2.4.9
Gene ID
51151
Reactome Pathway
Melanin biosynthesis (R-HSA-5662702 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
1 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sucrose DMVWUCF Discovery agent N.A. Investigative [1]
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Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 2.88E-03 5.74E-02 3.22E-01
Adrenocortical carcinoma 2D11.Z Kidney 2.76E-01 -6.59E-02 -3.86E-01
Alopecia ED70 Skin from scalp 1.11E-08 -6.65E-01 -1.39E+00
Alzheimer's disease 8A20 Entorhinal cortex 1.59E-01 -2.44E-02 -1.82E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 4.40E-01 -2.52E-03 -2.37E-02
Aortic stenosis BB70 Calcified aortic valve 8.25E-01 2.14E-02 3.91E-02
Apnea 7A40 Hyperplastic tonsil 6.14E-01 -5.14E-02 -1.97E-01
Arthropathy FA00-FA5Z Peripheral blood 5.06E-01 4.97E-02 5.57E-01
Asthma CA23 Nasal and bronchial airway 1.81E-07 -1.84E-01 -5.53E-01
Atopic dermatitis EA80 Skin 4.36E-02 1.08E-01 9.88E-01
Autism 6A02 Whole blood 3.70E-01 3.88E-02 2.31E-01
Autoimmune uveitis 9A96 Peripheral monocyte 5.71E-02 -2.32E-01 -1.70E+00
Autosomal dominant monocytopenia 4B04 Whole blood 8.50E-01 -6.40E-03 -7.07E-02
Bacterial infection of gingival 1C1H Gingival tissue 2.39E-01 -9.51E-02 -3.48E-01
Batten disease 5C56.1 Whole blood 5.23E-01 2.70E-02 3.86E-01
Behcet's disease 4A62 Peripheral blood 3.96E-02 -1.39E-01 -1.14E+00
Bipolar disorder 6A60-6A6Z Prefrontal cortex 6.58E-02 -6.84E-02 -5.09E-01
Bladder cancer 2C94 Bladder tissue 3.10E-04 4.52E-01 2.48E+00
Breast cancer 2C60-2C6Z Breast tissue 8.44E-03 -1.21E-02 -4.98E-02
Cardioembolic stroke 8B11.20 Whole blood 1.57E-02 1.91E-01 8.30E-01
Cervical cancer 2C77 Cervical tissue 1.32E-01 -3.89E-02 -1.50E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 3.66E-01 -1.19E-02 -4.30E-02
Chronic hepatitis C 1E51.1 Whole blood 8.72E-01 -4.04E-02 -3.83E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 2.85E-01 7.26E-02 3.83E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 4.20E-02 7.75E-02 4.93E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 8.71E-01 9.95E-03 1.81E-01
Colon cancer 2B90 Colon tissue 6.07E-03 -4.88E-02 -2.09E-01
Coronary artery disease BA80-BA8Z Peripheral blood 6.10E-01 3.04E-02 2.52E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 9.86E-01 -8.45E-03 -5.85E-02
Endometriosis GA10 Endometrium tissue 6.42E-03 5.81E-02 3.83E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 6.82E-01 3.46E-02 2.32E-01
Familial hypercholesterolemia 5C80.00 Whole blood 5.16E-01 -7.05E-02 -3.60E-01
Gastric cancer 2B72 Gastric tissue 6.17E-02 -2.04E-01 -1.94E+00
Glioblastopma 2A00.00 Nervous tissue 6.66E-04 -3.75E-02 -1.71E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 2.31E-06 -5.84E-01 -2.75E+00
Head and neck cancer 2D42 Head and neck tissue 1.07E-01 2.81E-02 1.47E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 1.86E-01 5.10E-03 2.70E-02
Huntington's disease 8A01.10 Whole blood 8.15E-02 1.32E-01 9.82E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 1.76E-01 -6.43E-02 -5.20E-01
Immunodeficiency 4A00-4A20 Peripheral blood 9.10E-01 1.79E-02 2.62E-01
Influenza 1.00E+30 Whole blood 9.45E-01 3.25E-02 3.15E-01
Interstitial cystitis GC00.3 Bladder tissue 1.83E-01 1.14E-01 1.00E+00
Intracranial aneurysm 8B01.0 Intracranial artery 7.15E-02 -7.74E-02 -4.79E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 1.85E-01 3.21E-02 1.32E-01
Ischemic stroke 8B11 Peripheral blood 6.14E-03 9.51E-02 7.40E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 2.90E-02 6.86E-02 4.09E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 7.13E-01 2.67E-02 1.55E-01
Lateral sclerosis 8B60.4 Skin 1.25E-01 9.75E-02 1.13E+00
Liver cancer 2C12.0 Liver tissue 3.21E-01 -1.85E-01 -8.70E-01
Liver failure DB99.7-DB99.8 Liver tissue 2.82E-01 -5.20E-02 -3.34E-01
Lung cancer 2C25 Lung tissue 6.62E-01 -1.11E-02 -7.56E-02
Lupus erythematosus 4A40 Whole blood 1.22E-01 -3.76E-02 -1.18E-01
Major depressive disorder 6A70-6A7Z Whole blood 7.12E-01 -4.24E-02 -2.27E-01
Major depressive disorder 6A70-6A7Z Hippocampus 1.38E-01 4.86E-02 4.14E-01
Melanoma 2C30 Skin 9.26E-07 1.94E+00 1.56E+00
Multiple myeloma 2A83.1 Bone marrow 3.24E-05 -3.67E-01 -3.21E+00
Multiple myeloma 2A83.1 Peripheral blood 1.46E-01 6.06E-02 3.14E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 4.10E-01 1.21E-01 9.61E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 2.70E-02 -4.16E-02 -2.59E-01
Myelofibrosis 2A20.2 Whole blood 6.25E-01 1.67E-02 1.39E-01
Myocardial infarction BA41-BA50 Peripheral blood 4.98E-02 1.32E-01 4.14E-01
Myopathy 8C70.6 Muscle tissue 5.49E-02 -9.14E-02 -6.58E-01
Neonatal sepsis KA60 Whole blood 2.66E-01 3.68E-02 1.74E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 2.06E-02 -5.16E-01 -1.11E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 2.68E-01 -5.97E-02 -4.46E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 6.83E-01 -8.96E-04 -6.98E-03
Olive pollen allergy CA08.00 Peripheral blood 7.90E-02 1.00E-01 8.69E-01
Oral cancer 2B6E Oral tissue 2.88E-06 -3.53E-01 -1.26E+00
Osteoarthritis FA00-FA0Z Synovial tissue 4.61E-01 -9.47E-02 -3.43E-01
Osteoporosis FB83.1 Bone marrow 8.82E-02 1.82E-01 1.52E+00
Ovarian cancer 2C73 Ovarian tissue 3.60E-02 -2.29E-01 -7.96E-01
Pancreatic cancer 2C10 Pancreas 3.53E-02 -1.36E-01 -5.23E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 6.54E-01 -7.28E-02 -5.35E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 4.13E-02 -1.13E-01 -7.63E-01
Pituitary cancer 2D12 Pituitary tissue 5.94E-01 1.31E-01 3.82E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 7.18E-01 1.30E-01 5.87E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 7.88E-01 2.22E-03 2.30E-02
Polycythemia vera 2A20.4 Whole blood 1.03E-03 9.84E-02 9.06E-01
Pompe disease 5C51.3 Biceps muscle 6.09E-01 -2.99E-02 -2.47E-01
Preterm birth KA21.4Z Myometrium 6.49E-01 8.76E-02 1.20E+00
Prostate cancer 2C82 Prostate 8.19E-04 5.83E-02 1.02E-01
Psoriasis EA90 Skin 4.14E-04 1.63E-01 7.14E-01
Rectal cancer 2B92 Rectal colon tissue 1.56E-01 -1.75E-01 -1.16E+00
Renal cancer 2C90-2C91 Kidney 3.14E-01 -1.13E-01 -3.98E-01
Retinoblastoma 2D02.2 Uvea 1.50E-07 3.97E+00 3.93E+01
Rheumatoid arthritis FA20 Synovial tissue 1.06E-01 -8.36E-02 -2.69E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 4.61E-01 -4.08E-02 -4.69E-01
Schizophrenia 6A20 Prefrontal cortex 6.09E-01 1.32E-02 5.14E-02
Schizophrenia 6A20 Superior temporal cortex 8.53E-01 -2.96E-02 -2.74E-01
Scleroderma 4A42.Z Whole blood 2.99E-01 -6.57E-02 -3.94E-01
Seizure 8A60-8A6Z Whole blood 2.53E-01 -1.79E-01 -1.03E+00
Sensitive skin EK0Z Skin 3.33E-01 5.28E-02 4.56E-01
Sepsis with septic shock 1G41 Whole blood 1.85E-02 5.37E-02 2.65E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 9.80E-02 5.09E-01 1.66E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 1.64E-01 1.46E-01 7.88E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 7.42E-02 1.07E-01 1.76E+00
Sjogren's syndrome 4A43.2 Salivary gland tissue 6.81E-01 7.57E-02 5.81E-01
Skin cancer 2C30-2C3Z Skin 4.37E-57 1.95E+00 5.40E+00
Thrombocythemia 3B63 Whole blood 5.22E-02 1.10E-01 8.96E-01
Thrombocytopenia 3B64 Whole blood 1.38E-01 2.61E-01 1.90E+00
Thyroid cancer 2D10 Thyroid 7.40E-06 9.16E-02 4.61E-01
Tibial muscular dystrophy 8C75 Muscle tissue 2.00E-03 -2.03E-01 -1.12E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 1.54E-01 9.97E-02 1.20E+00
Type 2 diabetes 5A11 Liver tissue 3.06E-02 -2.22E-01 -1.65E+00
Ureter cancer 2C92 Urothelium 2.74E-02 6.95E-02 4.98E-01
Uterine cancer 2C78 Endometrium tissue 8.49E-01 -7.95E-03 -3.49E-02
Vitiligo ED63.0 Skin 1.09E-02 -4.63E-01 -1.45E+00
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⏷ Show the Full List of Expression Under 107 Diseases

References

1 Identification of amino acids important for substrate specificity in sucrose transporters using gene shuffling. J Biol Chem. 2012 Aug 31;287(36):30296-304.