Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTNY0C2)

DTP Name Sodium/hydrogen exchanger 8 (SLC9A8)
Gene Name SLC9A8
UniProt ID
Q9Y2E8 (SL9A8_HUMAN)
VARIDT ID
DTD0493
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Synonyms KIAA0939; NHE-8; NHE8; Na(+)/H(+) exchanger 8; SLC9A8; Solute carrier family 9 member 8
DTP Family Monovalent Cation:Proton Antiporter-1 (CPA1) family ;
Tissue Specificity Ubiquitous. Strongly expressed in skeletalmuscle and kidney.
Sequence
MGEKMAEEERFPNTTHEGFNVTLHTTLVVTTKLVLPTPGKPILPVQTGEQAQQEEQSSGM
TIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKIIEFKKLANWKEEEM
FRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQAD
VISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTA
EGLTRKNMSDVSGWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFG
MMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCET
CVFAFLGLSIFSFPHKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIM
WFSGLRGAIPYALSLHLDLEPMEKRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDIEDAK
AHRRNKKDVNLSKTEKMGNTVESEHLSELTEEEYEAHYIRRQDLKGFVWLDAKYLNPFFT
RRLTQEDLHHGRIQMKTLTNKWYEEVRQGPSGSEDDEQELL
Function This transporter mediates and participates in regulating pH value to eliminate acids generated by active metabolism or to combat adverse environmental conditions.
Endogenous Substrate(s) Na+
TCDB ID
2.A.36.1.9
Gene ID
23315
Reactome Pathway
Sodium/Proton exchangers (R-HSA-425986 )

Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 4.97E-19 -5.70E-01 -1.10E+00
Adrenocortical carcinoma 2D11.Z Kidney 9.23E-03 -3.32E-01 -1.03E+00
Alopecia ED70 Skin from scalp 1.14E-03 1.86E-01 7.19E-01
Alzheimer's disease 8A20 Entorhinal cortex 7.00E-02 8.65E-02 3.92E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 1.63E-02 2.49E-01 8.70E-01
Aortic stenosis BB70 Calcified aortic valve 6.58E-01 -1.17E-01 -1.93E-01
Apnea 7A40 Hyperplastic tonsil 6.06E-02 6.04E-01 1.96E+00
Arthropathy FA00-FA5Z Peripheral blood 1.24E-01 3.02E-01 6.73E-01
Asthma CA23 Nasal and bronchial airway 3.02E-06 2.85E-01 5.78E-01
Atopic dermatitis EA80 Skin 2.33E-08 4.19E-01 2.73E+00
Autism 6A02 Whole blood 6.26E-01 -1.56E-01 -3.61E-01
Autoimmune uveitis 9A96 Peripheral monocyte 2.54E-02 1.11E+00 2.38E+00
Autosomal dominant monocytopenia 4B04 Whole blood 5.65E-01 2.41E-01 5.50E-01
Bacterial infection of gingival 1C1H Gingival tissue 9.84E-01 1.14E-02 3.71E-02
Batten disease 5C56.1 Whole blood 6.57E-01 1.01E-01 4.73E-01
Behcet's disease 4A62 Peripheral blood 4.37E-01 -1.85E-02 -5.76E-02
Bipolar disorder 6A60-6A6Z Prefrontal cortex 3.99E-02 8.82E-02 5.39E-01
Bladder cancer 2C94 Bladder tissue 1.72E-02 -2.38E-01 -1.06E+00
Breast cancer 2C60-2C6Z Breast tissue 1.62E-20 2.97E-01 8.44E-01
Cardioembolic stroke 8B11.20 Whole blood 1.23E-01 9.80E-02 3.64E-01
Cervical cancer 2C77 Cervical tissue 6.65E-01 -6.65E-02 -1.14E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 6.32E-01 7.92E-02 9.16E-02
Chronic hepatitis C 1E51.1 Whole blood 7.91E-01 2.70E-01 4.92E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 2.48E-01 -2.23E-02 -7.31E-02
Chronic obstructive pulmonary disease CA22 Small airway epithelium 3.53E-01 8.97E-03 2.37E-02
Chronic rhinosinusitis CA0A Sinus mucosa tissue 8.97E-01 -2.66E-03 -1.12E-02
Colon cancer 2B90 Colon tissue 8.04E-01 -9.20E-02 -2.43E-01
Coronary artery disease BA80-BA8Z Peripheral blood 3.25E-01 2.13E-01 5.50E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 3.01E-01 -1.71E-01 -7.54E-01
Endometriosis GA10 Endometrium tissue 1.04E-01 2.10E-01 5.04E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 2.38E-01 1.12E-01 1.05E+00
Familial hypercholesterolemia 5C80.00 Whole blood 3.00E-04 -4.35E-01 -9.78E-01
Gastric cancer 2B72 Gastric tissue 5.32E-01 4.11E-01 6.97E-01
Glioblastopma 2A00.00 Nervous tissue 1.75E-64 3.98E-01 1.22E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 2.10E-02 -3.85E-01 -7.60E-01
Head and neck cancer 2D42 Head and neck tissue 6.78E-27 -1.09E+00 -1.49E+00
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 5.85E-02 4.47E-02 1.45E-01
Huntington's disease 8A01.10 Whole blood 5.32E-01 -1.29E-01 -4.18E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 9.65E-02 -3.82E-01 -1.48E+00
Immunodeficiency 4A00-4A20 Peripheral blood 4.57E-01 -1.39E-02 -1.64E-01
Influenza 1.00E+30 Whole blood 6.06E-01 5.69E-02 1.42E-01
Interstitial cystitis GC00.3 Bladder tissue 8.43E-01 3.76E-02 1.72E-01
Intracranial aneurysm 8B01.0 Intracranial artery 1.87E-01 -8.93E-02 -3.06E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 8.14E-02 -6.68E-03 -2.56E-02
Ischemic stroke 8B11 Peripheral blood 2.61E-01 -5.12E-02 -2.44E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 7.01E-01 -8.83E-02 -1.71E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 7.00E-01 4.97E-02 3.04E-01
Lateral sclerosis 8B60.4 Skin 8.68E-01 2.42E-02 1.54E-01
Liver cancer 2C12.0 Liver tissue 3.18E-03 -3.37E-01 -5.95E-01
Liver failure DB99.7-DB99.8 Liver tissue 3.43E-01 -2.05E-01 -5.34E-01
Lung cancer 2C25 Lung tissue 1.95E-13 -1.81E-01 -4.86E-01
Lupus erythematosus 4A40 Whole blood 9.27E-15 8.00E-01 1.31E+00
Major depressive disorder 6A70-6A7Z Whole blood 7.96E-03 1.18E-01 5.04E-01
Major depressive disorder 6A70-6A7Z Hippocampus 4.95E-02 6.19E-02 3.70E-01
Melanoma 2C30 Skin 4.03E-01 -3.04E-01 -4.19E-01
Multiple myeloma 2A83.1 Bone marrow 3.14E-08 4.14E-01 5.58E+00
Multiple myeloma 2A83.1 Peripheral blood 3.07E-01 -5.48E-02 -2.26E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 5.41E-01 2.97E-02 1.26E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 7.69E-01 1.15E-01 3.21E-01
Myelofibrosis 2A20.2 Whole blood 2.29E-02 1.41E-01 5.49E-01
Myocardial infarction BA41-BA50 Peripheral blood 3.57E-02 3.35E-01 4.43E-01
Myopathy 8C70.6 Muscle tissue 9.96E-03 -2.99E-01 -1.07E+00
Neonatal sepsis KA60 Whole blood 3.52E-02 1.61E-01 3.23E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 4.96E-01 1.69E-02 5.72E-02
Non-alcoholic fatty liver disease DB92 Liver tissue 3.21E-01 3.49E-02 1.25E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 8.81E-01 -2.26E-02 -5.14E-02
Olive pollen allergy CA08.00 Peripheral blood 8.59E-01 -7.66E-02 -1.91E-01
Oral cancer 2B6E Oral tissue 2.20E-01 -6.45E-02 -1.59E-01
Osteoarthritis FA00-FA0Z Synovial tissue 3.02E-01 3.52E-03 1.62E-02
Osteoporosis FB83.1 Bone marrow 7.19E-01 1.28E-02 6.40E-02
Ovarian cancer 2C73 Ovarian tissue 3.06E-03 4.98E-01 1.44E+00
Pancreatic cancer 2C10 Pancreas 4.20E-03 6.07E-01 1.20E+00
Parkinson's disease 8A00.0 Substantia nigra tissue 7.48E-01 5.88E-02 3.26E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 1.15E-01 1.50E-01 6.12E-01
Pituitary cancer 2D12 Pituitary tissue 2.18E-01 -4.01E-01 -8.30E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 8.40E-01 -1.66E-01 -3.73E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 2.87E-02 1.51E-01 7.59E-01
Polycythemia vera 2A20.4 Whole blood 7.61E-08 3.52E-01 1.35E+00
Pompe disease 5C51.3 Biceps muscle 5.86E-01 -2.92E-01 -1.14E+00
Preterm birth KA21.4Z Myometrium 7.71E-01 3.58E-02 1.18E-01
Prostate cancer 2C82 Prostate 4.05E-06 7.52E-01 1.87E+00
Psoriasis EA90 Skin 1.45E-11 1.77E-01 5.19E-01
Rectal cancer 2B92 Rectal colon tissue 3.22E-02 2.92E-01 9.24E-01
Renal cancer 2C90-2C91 Kidney 5.76E-01 7.16E-02 1.68E-01
Retinoblastoma 2D02.2 Uvea 6.13E-09 1.11E+00 3.13E+00
Rheumatoid arthritis FA20 Synovial tissue 5.67E-02 4.09E-01 8.25E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 4.29E-02 -6.84E-02 -3.70E-01
Schizophrenia 6A20 Prefrontal cortex 4.76E-01 4.43E-02 1.26E-01
Schizophrenia 6A20 Superior temporal cortex 8.54E-01 -1.65E-02 -1.51E-01
Scleroderma 4A42.Z Whole blood 9.29E-06 2.74E-01 1.97E+00
Seizure 8A60-8A6Z Whole blood 8.05E-02 1.52E-01 3.57E-01
Sensitive skin EK0Z Skin 4.98E-01 -7.27E-02 -5.42E-01
Sepsis with septic shock 1G41 Whole blood 4.26E-24 5.47E-01 1.08E+00
Shwachman-Diamond syndrome 3A70.0 Bone marrow 2.16E-01 -4.09E-01 -2.25E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 1.01E-01 -1.58E-01 -4.62E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 4.34E-01 -1.57E-02 -3.71E-02
Sjogren's syndrome 4A43.2 Salivary gland tissue 9.74E-01 1.08E-01 6.22E-01
Skin cancer 2C30-2C3Z Skin 9.49E-27 4.96E-01 9.12E-01
Thrombocythemia 3B63 Whole blood 1.79E-02 1.65E-01 6.66E-01
Thrombocytopenia 3B64 Whole blood 6.30E-01 1.08E-01 2.36E-01
Thyroid cancer 2D10 Thyroid 8.44E-16 -3.40E-01 -9.19E-01
Tibial muscular dystrophy 8C75 Muscle tissue 5.19E-03 -5.14E-01 -1.12E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 3.13E-01 2.16E-01 1.28E+00
Type 2 diabetes 5A11 Liver tissue 3.69E-01 1.21E-01 6.09E-01
Ureter cancer 2C92 Urothelium 5.33E-02 -1.03E-01 -6.33E-01
Uterine cancer 2C78 Endometrium tissue 4.92E-02 -8.60E-02 -1.63E-01
Vitiligo ED63.0 Skin 1.62E-01 -1.48E-01 -8.29E-01
------------------------------------------------------------------------------------
⏷ Show the Full List of Expression Under 107 Diseases