Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTP7AEQ)

DTP Name Glycoprotein-associated amino acid transporter b0, +AT1 (SLC7A9)
Gene Name SLC7A9
UniProt ID
P82251 (BAT1_HUMAN)
VARIDT ID
DTD0476
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms BAT1; CSNU3; SLC7A9; Solute carrier family 7 member 9; b(0,+)-type amino acid transporter 1; b(0,+)AT1
DTP Family Amino Acid-Polyamine-Organocation (APC) Family
L-type Amino Acid Transporter (LAT) Family
Tissue Specificity Expressed in the brush border membrane in thekidney (at protein level). Kidney, small intestine, liver andplacenta.
Sequence
MGDTGLRKRREDEKSIQSQEPKTTSLQKELGLISGISIIVGTIIGSGIFVSPKSVLSNTE
AVGPCLIIWAACGVLATLGALCFAELGTMITKSGGEYPYLMEAYGPIPAYLFSWASLIVI
KPTSFAIICLSFSEYVCAPFYVGCKPPQIVVKCLAAAAILFISTVNSLSVRLGSYVQNIF
TAAKLVIVAIIIISGLVLLAQGNTKNFDNSFEGAQLSVGAISLAFYNGLWAYDGWNQLNY
ITEELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQSQAVAVTFGDRVLYP
ASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVRRLTPAPAIIFYGI
IATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRFTRKELERPIKVPVVIPVLMTLI
SVFLVLAPIISKPTWEYLYCVLFILSGLLFYFLFVHYKFGWAQKISKPITMHLQMLMEVV
PPEEDPE
Function
This transporter thought to be responsible for the high-affinity reabsorption of cystine in the kidney tubule. Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity).
Endogenous Substrate(s) Cystine; Neutral and dibasic amino acids
TCDB ID
2.A.3.8.19
Gene ID
11136
KEGG Pathway
( )
Reactome Pathway
Amino acid transport across the plasma membrane (R-HSA-352230 )
Defective SLC3A1 causes cystinuria (CSNU) (R-HSA-5619113 )
Defective SLC7A9 causes cystinuria (CSNU) (R-HSA-5660883 )
Basigin interactions (R-HSA-210991 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
1 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-citrulline DMT4K0Z Acute lung injury NB32.3 Phase 3 [1]
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Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 1.79E-01 5.34E-03 2.69E-02
Adrenocortical carcinoma 2D11.Z Kidney 2.45E-02 9.38E-02 3.47E-01
Alopecia ED70 Skin from scalp 8.90E-01 7.17E-03 1.46E-02
Alzheimer's disease 8A20 Entorhinal cortex 2.58E-04 2.33E-01 7.35E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 8.49E-01 -2.91E-02 -1.80E-01
Aortic stenosis BB70 Calcified aortic valve 3.16E-01 -1.37E-01 -3.97E-01
Apnea 7A40 Hyperplastic tonsil 7.13E-01 3.58E-02 1.10E-01
Arthropathy FA00-FA5Z Peripheral blood 2.80E-01 8.87E-02 6.98E-01
Asthma CA23 Nasal and bronchial airway 3.37E-01 2.40E-01 2.44E-01
Atopic dermatitis EA80 Skin 8.07E-02 7.09E-02 4.58E-01
Autism 6A02 Whole blood 3.33E-01 -3.48E-02 -1.65E-01
Autoimmune uveitis 9A96 Peripheral monocyte 7.54E-02 -1.41E-01 -7.95E-01
Autosomal dominant monocytopenia 4B04 Whole blood 9.60E-01 0.00E+00 0.00E+00
Bacterial infection of gingival 1C1H Gingival tissue 8.53E-01 6.34E-02 1.51E-01
Batten disease 5C56.1 Whole blood 4.88E-01 2.32E-02 6.21E-02
Behcet's disease 4A62 Peripheral blood 8.06E-01 1.73E-01 6.10E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 9.88E-01 3.78E-04 1.62E-03
Bladder cancer 2C94 Bladder tissue 8.71E-05 6.42E-01 2.92E+00
Breast cancer 2C60-2C6Z Breast tissue 1.49E-08 1.14E-01 2.87E-01
Cardioembolic stroke 8B11.20 Whole blood 5.13E-02 2.75E-01 4.30E-01
Cervical cancer 2C77 Cervical tissue 7.97E-03 -1.87E-01 -7.43E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 8.02E-01 -3.64E-02 -1.28E-01
Chronic hepatitis C 1E51.1 Whole blood 4.95E-02 1.89E-01 1.06E+00
Chronic obstructive pulmonary disease CA22 Lung tissue 3.77E-01 1.26E-01 4.83E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 2.86E-01 1.42E-01 3.18E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 2.60E-01 -4.55E-02 -5.17E-01
Colon cancer 2B90 Colon tissue 3.53E-02 5.89E-02 7.65E-02
Coronary artery disease BA80-BA8Z Peripheral blood 2.31E-01 -2.87E-01 -6.99E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 3.92E-01 -3.23E-01 -9.95E-01
Endometriosis GA10 Endometrium tissue 8.06E-01 -3.21E-02 -9.42E-02
Familial hypercholesterolemia 5C80.00 Peripheral blood 9.76E-01 9.04E-03 4.70E-02
Familial hypercholesterolemia 5C80.00 Whole blood 7.34E-05 -3.99E-01 -1.31E+00
Gastric cancer 2B72 Gastric tissue 3.16E-03 5.88E-01 2.94E+00
Glioblastopma 2A00.00 Nervous tissue 1.37E-02 8.89E-02 2.11E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 2.03E-01 1.15E-01 2.05E-01
Head and neck cancer 2D42 Head and neck tissue 7.08E-13 -3.34E-01 -7.48E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 4.37E-02 -2.44E-01 -7.65E-01
Huntington's disease 8A01.10 Whole blood 4.68E-01 -1.28E-01 -9.39E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 5.60E-01 6.47E-02 3.49E-01
Immunodeficiency 4A00-4A20 Peripheral blood 1.16E-01 -1.15E-01 -6.62E-01
Influenza 1.00E+30 Whole blood 4.78E-01 1.32E-03 2.05E-02
Interstitial cystitis GC00.3 Bladder tissue 3.05E-01 -1.55E-01 -9.83E-01
Intracranial aneurysm 8B01.0 Intracranial artery 2.67E-01 -1.30E-01 -4.92E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 2.39E-01 4.03E-02 9.96E-02
Ischemic stroke 8B11 Peripheral blood 3.10E-01 3.82E-02 1.73E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 7.54E-01 -5.37E-02 -1.57E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 8.16E-01 2.67E-01 3.35E-01
Lateral sclerosis 8B60.4 Skin 2.99E-01 8.82E-02 1.01E+00
Liver cancer 2C12.0 Liver tissue 6.53E-05 -1.64E-01 -3.08E-01
Liver failure DB99.7-DB99.8 Liver tissue 2.57E-02 -2.22E+00 -4.70E+00
Lung cancer 2C25 Lung tissue 2.10E-44 2.80E-01 1.12E+00
Lupus erythematosus 4A40 Whole blood 6.04E-03 -1.85E-01 -3.56E-01
Major depressive disorder 6A70-6A7Z Whole blood 1.60E-01 8.65E-02 2.72E-01
Major depressive disorder 6A70-6A7Z Hippocampus 2.85E-01 -3.44E-02 -1.57E-01
Melanoma 2C30 Skin 9.12E-02 -9.40E-02 -1.09E-01
Multiple myeloma 2A83.1 Bone marrow 6.37E-02 -2.16E-01 -7.35E-01
Multiple myeloma 2A83.1 Peripheral blood 1.01E-01 2.28E-01 1.61E+00
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 5.76E-01 -1.48E-01 -5.25E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 3.42E-02 1.82E-01 7.09E-01
Myelofibrosis 2A20.2 Whole blood 5.44E-01 -6.65E-02 -5.35E-01
Myocardial infarction BA41-BA50 Peripheral blood 7.09E-01 -1.16E-01 -1.55E-01
Myopathy 8C70.6 Muscle tissue 1.69E-01 -3.19E-01 -1.14E+00
Neonatal sepsis KA60 Whole blood 5.13E-01 2.43E-02 1.16E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 7.09E-03 -7.00E-01 -1.51E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 2.96E-01 -2.10E-01 -7.31E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 5.05E-01 7.88E-02 8.43E-01
Olive pollen allergy CA08.00 Peripheral blood 1.98E-01 8.94E-02 4.22E-01
Oral cancer 2B6E Oral tissue 8.25E-01 -2.75E-01 -6.70E-01
Osteoarthritis FA00-FA0Z Synovial tissue 7.36E-02 2.32E-01 9.68E-01
Osteoporosis FB83.1 Bone marrow 3.37E-02 2.79E-01 8.77E+00
Ovarian cancer 2C73 Ovarian tissue 5.99E-02 1.37E-01 4.96E-01
Pancreatic cancer 2C10 Pancreas 3.46E-01 -1.27E-02 -2.74E-02
Parkinson's disease 8A00.0 Substantia nigra tissue 4.00E-01 1.05E-01 4.10E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 8.80E-01 -4.22E-02 -2.86E-01
Pituitary cancer 2D12 Pituitary tissue 2.48E-02 -5.87E-01 -1.16E+00
Pituitary gonadotrope tumour 2D12 Pituitary tissue 9.07E-01 -1.35E-01 -3.63E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 1.02E-01 3.79E-02 2.52E-01
Polycythemia vera 2A20.4 Whole blood 7.82E-01 -3.29E-02 -2.13E-01
Pompe disease 5C51.3 Biceps muscle 1.25E-01 2.56E-01 1.21E+00
Preterm birth KA21.4Z Myometrium 9.41E-01 1.82E-01 5.15E-01
Prostate cancer 2C82 Prostate 1.46E-03 -5.71E-01 -9.30E-01
Psoriasis EA90 Skin 3.46E-08 -2.55E-01 -8.71E-01
Rectal cancer 2B92 Rectal colon tissue 1.22E-01 7.78E-02 3.15E-01
Renal cancer 2C90-2C91 Kidney 1.27E-02 -2.08E+00 -1.33E+00
Retinoblastoma 2D02.2 Uvea 2.46E-08 -1.44E+00 -3.22E+00
Rheumatoid arthritis FA20 Synovial tissue 1.25E-04 4.71E-01 3.53E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 9.86E-01 -4.10E-02 -2.22E-01
Schizophrenia 6A20 Prefrontal cortex 5.83E-01 -1.81E-02 -4.04E-02
Schizophrenia 6A20 Superior temporal cortex 5.68E-01 -3.21E-02 -1.69E-01
Scleroderma 4A42.Z Whole blood 4.14E-01 -5.28E-02 -3.69E-01
Seizure 8A60-8A6Z Whole blood 4.17E-01 -3.15E-02 -2.52E-01
Sensitive skin EK0Z Skin 4.82E-01 1.54E-01 4.38E-01
Sepsis with septic shock 1G41 Whole blood 4.86E-04 9.27E-02 4.01E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 5.67E-02 5.44E-01 1.43E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 2.34E-01 -3.37E-04 -2.06E-03
Simpson golabi behmel syndrome LD2C Adipose tissue 4.92E-01 5.40E-03 3.34E-02
Sjogren's syndrome 4A43.2 Salivary gland tissue 2.85E-01 6.40E-02 2.12E+00
Skin cancer 2C30-2C3Z Skin 7.12E-04 -1.66E-01 -4.31E-01
Thrombocythemia 3B63 Whole blood 9.81E-02 4.78E-02 3.25E-01
Thrombocytopenia 3B64 Whole blood 5.86E-01 1.32E-02 7.43E-02
Thyroid cancer 2D10 Thyroid 1.16E-03 -1.27E-01 -2.66E-01
Tibial muscular dystrophy 8C75 Muscle tissue 9.66E-01 9.67E-03 5.20E-02
Tuberous sclerosis complex LD2D.2 Perituberal tissue 2.21E-02 3.79E-01 2.69E+00
Type 2 diabetes 5A11 Liver tissue 6.33E-01 2.18E-01 4.44E-01
Ureter cancer 2C92 Urothelium 6.24E-01 -5.50E-02 -2.25E-01
Uterine cancer 2C78 Endometrium tissue 1.78E-01 3.73E-04 1.25E-03
Vitiligo ED63.0 Skin 2.28E-01 -4.13E-01 -8.14E-01
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References

1 Transport characteristics of L-citrulline in renal apical membrane of proximal tubular cells. Biopharm Drug Dispos. 2009 Apr;30(3):126-37.