Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTPAQJO)

DTP Name Monocarboxylate transporter 10 (SLC16A10)
Gene Name SLC16A10
UniProt ID
Q8TF71 (MOT10_HUMAN)
VARIDT ID
DTD0101
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms Aromatic amino acid transporter 1; Solute carrier family 16 member 10; T-type amino acid transporter 1; SLC16A10; MCT10; TAT1
DTP Family Major Facilitator Superfamily (MFS)
Monocarboxylate Transporter (MCT) Family
Tissue Specificity Strongly expressed in kidney and skeletalmuscle and at lower level in placenta and heart.
Sequence
MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVELAGPATAEPHE
PPEPPEGGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMVFKTAWVGSL
SMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGC
SFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIF
MFVLFLAGFTYRPLATSTKDKESGGSGSSLFSRKKFSPPKKIFNFAIFKVTAYAVWAVGI
PLALFGYFVPYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYVPGVKKVY
LQVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAI
GFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLCFIPWIHSKKQREI
SKTTGKEKMEKMLENQNSLLSSSSGMFKKESDSII
Function This Sodium-independent transporter mediates the uptake of aromatic acids, and function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells.
Endogenous Substrate(s) Thyroid hormones
TCDB ID
2.A.1.13.8
Gene ID
117247
KEGG Pathway
Thyroid hormone signaling pathway (hsa04919 )
Protein digestion and absorption (hsa04974 )
Reactome Pathway
Amino acid transport across the plasma membrane (R-HSA-352230 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
1 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-Tryptophan DMIBH7M Depression 6A70-6A7Z Approved [1]
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Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 2.16E-07 -9.61E-02 -3.25E-01
Adrenocortical carcinoma 2D11.Z Kidney 7.62E-02 1.58E-01 4.19E-01
Alopecia ED70 Skin from scalp 6.05E-02 2.15E-01 3.23E-01
Alzheimer's disease 8A20 Entorhinal cortex 6.61E-03 -1.56E-01 -2.95E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 3.57E-01 4.83E-02 1.17E-01
Aortic stenosis BB70 Calcified aortic valve 1.01E-01 5.02E-01 1.34E+00
Apnea 7A40 Hyperplastic tonsil 9.34E-01 -6.15E-03 -4.88E-02
Arthropathy FA00-FA5Z Peripheral blood 5.19E-01 -3.36E-01 -6.72E-01
Asthma CA23 Nasal and bronchial airway 4.43E-02 -7.08E-02 -1.35E-01
Atopic dermatitis EA80 Skin 2.49E-09 -1.02E+00 -4.72E+00
Autism 6A02 Whole blood 6.23E-01 4.08E-02 7.85E-02
Autoimmune uveitis 9A96 Peripheral monocyte 3.53E-01 1.72E-01 5.13E-01
Autosomal dominant monocytopenia 4B04 Whole blood 2.00E-01 -8.67E-02 -5.90E-01
Bacterial infection of gingival 1C1H Gingival tissue 5.52E-05 -1.53E-01 -4.53E-01
Batten disease 5C56.1 Whole blood 3.75E-01 5.12E-02 6.76E-02
Behcet's disease 4A62 Peripheral blood 6.95E-01 -8.47E-02 -2.24E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 1.35E-01 1.34E-01 4.06E-01
Bladder cancer 2C94 Bladder tissue 1.22E-03 2.96E-01 1.41E+00
Breast cancer 2C60-2C6Z Breast tissue 1.58E-05 7.66E-03 2.42E-02
Cardioembolic stroke 8B11.20 Whole blood 1.09E-04 -6.16E-01 -1.17E+00
Cervical cancer 2C77 Cervical tissue 6.00E-02 1.40E-01 3.08E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 3.58E-01 3.21E-01 3.74E-01
Chronic hepatitis C 1E51.1 Whole blood 2.05E-01 1.90E-01 4.09E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 1.33E-01 2.41E-01 3.84E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 7.57E-01 1.84E-02 8.65E-02
Chronic rhinosinusitis CA0A Sinus mucosa tissue 2.84E-02 1.56E-01 1.38E+00
Colon cancer 2B90 Colon tissue 9.57E-01 -1.58E-01 -3.86E-01
Coronary artery disease BA80-BA8Z Peripheral blood 8.05E-02 -1.47E-01 -1.72E+00
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 7.04E-01 -1.33E-02 -4.26E-02
Endometriosis GA10 Endometrium tissue 2.11E-02 7.04E-02 4.62E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 8.05E-01 -2.92E-01 -5.32E-01
Familial hypercholesterolemia 5C80.00 Whole blood 5.26E-08 -2.25E-01 -7.88E-01
Gastric cancer 2B72 Gastric tissue 5.15E-01 -1.43E+00 -1.09E+00
Glioblastopma 2A00.00 Nervous tissue 3.77E-15 2.13E-02 4.62E-02
Glioma 2A00.0Y-2A00.0Z White matter tissue 3.46E-04 1.77E+00 1.70E+00
Head and neck cancer 2D42 Head and neck tissue 3.12E-10 1.84E-01 8.17E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 2.08E-01 -1.62E-01 -3.61E-01
Huntington's disease 8A01.10 Whole blood 9.08E-01 -1.16E-01 -5.04E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 9.09E-02 -5.16E-01 -7.39E-01
Immunodeficiency 4A00-4A20 Peripheral blood 7.69E-07 -1.12E+00 -4.28E+00
Influenza 1.00E+30 Whole blood 1.72E-01 -1.57E+00 -1.39E+00
Interstitial cystitis GC00.3 Bladder tissue 2.30E-01 1.87E-01 1.07E+00
Intracranial aneurysm 8B01.0 Intracranial artery 4.71E-03 1.09E+00 4.33E+00
Irritable bowel syndrome DD91.0 Rectal colon tissue 6.45E-01 -7.50E-02 -1.48E-01
Ischemic stroke 8B11 Peripheral blood 3.00E-01 -7.45E-02 -2.70E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 2.80E-01 1.39E-02 2.24E-02
Lateral sclerosis 8B60.4 Cervical spinal cord 3.68E-01 7.89E-02 2.76E-01
Lateral sclerosis 8B60.4 Skin 4.86E-01 -1.08E-01 -8.38E-01
Liver cancer 2C12.0 Liver tissue 9.79E-06 -1.08E+00 -1.04E+00
Liver failure DB99.7-DB99.8 Liver tissue 2.02E-03 -1.63E+00 -1.54E+00
Lung cancer 2C25 Lung tissue 1.25E-22 -8.58E-01 -1.09E+00
Lupus erythematosus 4A40 Whole blood 5.11E-10 -6.94E-01 -9.39E-01
Major depressive disorder 6A70-6A7Z Whole blood 9.57E-01 1.13E-01 1.79E-01
Major depressive disorder 6A70-6A7Z Hippocampus 8.45E-01 9.53E-02 2.82E-01
Melanoma 2C30 Skin 5.29E-01 -3.61E-01 -2.45E-01
Multiple myeloma 2A83.1 Bone marrow 2.31E-01 -1.11E-01 -6.48E-01
Multiple myeloma 2A83.1 Peripheral blood 3.04E-01 3.87E-02 2.37E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 1.62E-01 -2.94E-01 -6.35E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 2.18E-03 2.30E-01 8.21E-01
Myelofibrosis 2A20.2 Whole blood 9.91E-12 -6.36E-01 -1.58E+00
Myocardial infarction BA41-BA50 Peripheral blood 1.89E-04 -4.14E-01 -4.70E-01
Myopathy 8C70.6 Muscle tissue 4.51E-01 -2.37E-01 -4.64E-01
Neonatal sepsis KA60 Whole blood 3.56E-15 -8.11E-01 -9.82E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 3.49E-12 9.30E-01 3.94E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 2.43E-01 -4.67E-01 -8.04E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 5.75E-01 -2.21E-01 -2.34E-01
Olive pollen allergy CA08.00 Peripheral blood 4.37E-01 -5.28E-01 -3.35E-01
Oral cancer 2B6E Oral tissue 8.70E-02 5.29E-02 8.20E-02
Osteoarthritis FA00-FA0Z Synovial tissue 6.09E-01 1.36E-01 1.36E-01
Osteoporosis FB83.1 Bone marrow 6.81E-01 -6.41E-03 -4.62E-02
Ovarian cancer 2C73 Ovarian tissue 2.88E-05 3.79E-01 1.95E+00
Pancreatic cancer 2C10 Pancreas 4.01E-04 -1.47E+00 -1.31E+00
Parkinson's disease 8A00.0 Substantia nigra tissue 4.03E-01 0.00E+00 0.00E+00
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 6.40E-03 -3.71E-01 -9.07E-01
Pituitary cancer 2D12 Pituitary tissue 4.06E-01 3.00E-01 7.26E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 7.28E-02 1.16E+00 2.39E+00
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 5.30E-03 4.57E-01 1.19E+00
Polycythemia vera 2A20.4 Whole blood 1.10E-08 -6.46E-01 -1.61E+00
Pompe disease 5C51.3 Biceps muscle 2.81E-02 -7.23E-01 -1.14E+00
Preterm birth KA21.4Z Myometrium 1.04E-01 -3.36E-01 -5.48E-01
Prostate cancer 2C82 Prostate 8.13E-01 -6.58E-02 -9.59E-02
Psoriasis EA90 Skin 1.92E-19 8.51E-01 1.21E+00
Rectal cancer 2B92 Rectal colon tissue 5.00E-01 -3.19E-02 -9.23E-02
Renal cancer 2C90-2C91 Kidney 1.24E-04 -1.12E+00 -2.28E+00
Retinoblastoma 2D02.2 Uvea 2.64E-03 6.53E-01 3.77E+00
Rheumatoid arthritis FA20 Synovial tissue 2.45E-01 -4.36E-01 -4.24E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 9.40E-01 -1.65E-02 -1.12E-01
Schizophrenia 6A20 Prefrontal cortex 5.08E-01 6.02E-02 1.20E-01
Schizophrenia 6A20 Superior temporal cortex 6.74E-01 1.09E-03 6.08E-03
Scleroderma 4A42.Z Whole blood 1.65E-06 -1.12E+00 -3.63E+00
Seizure 8A60-8A6Z Whole blood 4.57E-01 2.15E-03 2.30E-03
Sensitive skin EK0Z Skin 1.75E-01 6.06E-01 1.33E+00
Sepsis with septic shock 1G41 Whole blood 2.35E-19 -6.47E-01 -7.12E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 3.04E-01 -1.89E-01 -6.60E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 3.77E-01 5.34E-04 4.85E-03
Simpson golabi behmel syndrome LD2C Adipose tissue 6.85E-01 3.58E-02 2.03E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 9.46E-01 2.90E-01 7.29E-01
Skin cancer 2C30-2C3Z Skin 1.35E-66 -1.84E+00 -2.23E+00
Thrombocythemia 3B63 Whole blood 7.00E-03 -7.25E-02 -1.84E-01
Thrombocytopenia 3B64 Whole blood 2.71E-01 -1.54E-01 -1.42E-01
Thyroid cancer 2D10 Thyroid 8.04E-01 -1.58E-01 -2.16E-01
Tibial muscular dystrophy 8C75 Muscle tissue 4.50E-02 -1.53E+00 -1.09E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 9.90E-01 7.30E-03 1.77E-02
Type 2 diabetes 5A11 Liver tissue 9.92E-01 2.66E-01 3.95E-01
Ureter cancer 2C92 Urothelium 7.75E-01 2.66E-02 1.57E-01
Uterine cancer 2C78 Endometrium tissue 2.67E-27 4.78E-01 1.41E+00
Vitiligo ED63.0 Skin 1.62E-01 3.75E-01 7.94E-01
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⏷ Show the Full List of Expression Under 107 Diseases

References

1 Phosphatidylserine synthesis required for the maximal tryptophan transport activity in Saccharomyces cerevisiae. Biosci Biotechnol Biochem. 2000 Jan;64(1):167-72.