Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTPKTHL)

DTP Name Creatine transporter 1 (SLC6A8)
Gene Name SLC6A8
UniProt ID
P48029 (SC6A8_HUMAN)
VARIDT ID
DTD0460
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms CCDS1; CRT; CRTR; CT1; CTR5; SLC6A8; Sodium- and chloride-dependent creatine transporter 1; Solute carrier family 6 member 8
DTP Family Neurotransmitter:Sodium Symporter (NSS) Family ;
Tissue Specificity Predominantly expressed in skeletal muscle andkidney. Also found in brain, heart, colon, testis and prostate.
Sequence
MAKKSAENGIYSVSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMD
FIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGS
INVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPD
CVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLL
ACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKL
GSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVF
SILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFV
GVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASG
TTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV
YYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWG
LHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM
Function This transporter mediates the uptake of creatine in muscles and brain.
Endogenous Substrate(s) Cl-; Na+
TCDB ID
2.A.22.3.11
Gene ID
6535
Reactome Pathway
Creatine metabolism (R-HSA-71288 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
1 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Creatine ALS-08 DMKD2BQ Motor neurone disease 8B60 Phase 3 [2]
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Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 2.34E-23 -1.42E+00 -1.63E+00
Adrenocortical carcinoma 2D11.Z Kidney 3.17E-02 3.51E-01 7.80E-01
Alopecia ED70 Skin from scalp 2.93E-02 -1.48E-01 -3.63E-01
Alzheimer's disease 8A20 Entorhinal cortex 3.74E-01 5.65E-02 1.84E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 8.49E-01 -4.41E-02 -1.35E-01
Aortic stenosis BB70 Calcified aortic valve 7.02E-01 1.51E-01 1.18E+00
Apnea 7A40 Hyperplastic tonsil 9.33E-01 -6.93E-02 -1.70E-01
Arthropathy FA00-FA5Z Peripheral blood 5.51E-01 1.65E-01 2.80E-01
Asthma CA23 Nasal and bronchial airway 2.74E-05 3.45E-01 3.45E-01
Atopic dermatitis EA80 Skin 6.13E-01 1.69E-01 4.13E-01
Autism 6A02 Whole blood 3.73E-03 -5.01E-01 -9.13E-01
Autoimmune uveitis 9A96 Peripheral monocyte 6.23E-01 -1.70E-01 -6.45E-01
Autosomal dominant monocytopenia 4B04 Whole blood 8.04E-01 -1.26E-01 -2.64E-01
Bacterial infection of gingival 1C1H Gingival tissue 7.24E-01 7.11E-02 1.37E-01
Batten disease 5C56.1 Whole blood 3.69E-01 2.06E-02 1.85E-01
Behcet's disease 4A62 Peripheral blood 6.33E-01 -2.71E-02 -6.38E-02
Bipolar disorder 6A60-6A6Z Prefrontal cortex 5.42E-01 -3.71E-03 -1.62E-02
Bladder cancer 2C94 Bladder tissue 1.60E-03 3.56E-01 1.22E+00
Breast cancer 2C60-2C6Z Breast tissue 7.13E-66 6.74E-01 1.44E+00
Cardioembolic stroke 8B11.20 Whole blood 2.49E-03 -8.40E-01 -9.37E-01
Cervical cancer 2C77 Cervical tissue 3.64E-02 3.89E-01 7.18E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 1.51E-02 2.66E-01 7.53E-01
Chronic hepatitis C 1E51.1 Whole blood 1.44E-02 1.22E-01 8.77E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 3.60E-01 1.69E-01 5.76E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 8.78E-01 -1.28E-01 -2.82E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 5.45E-04 1.20E+00 3.58E+00
Colon cancer 2B90 Colon tissue 6.96E-36 -8.18E-01 -1.38E+00
Coronary artery disease BA80-BA8Z Peripheral blood 9.57E-01 4.91E-02 1.79E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 3.28E-01 -1.16E-01 -5.55E-01
Endometriosis GA10 Endometrium tissue 2.28E-01 2.23E-02 7.12E-02
Familial hypercholesterolemia 5C80.00 Peripheral blood 7.89E-01 -1.21E-03 -4.21E-03
Familial hypercholesterolemia 5C80.00 Whole blood 6.41E-17 -1.82E+00 -2.07E+00
Gastric cancer 2B72 Gastric tissue 2.90E-01 5.03E-01 6.18E-01
Glioblastopma 2A00.00 Nervous tissue 1.03E-10 -4.04E-01 -5.34E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 8.84E-03 3.83E-01 7.64E-01
Head and neck cancer 2D42 Head and neck tissue 6.91E-10 5.16E-01 7.27E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 5.63E-01 1.40E-01 2.79E-01
Huntington's disease 8A01.10 Whole blood 3.15E-01 2.39E-01 5.70E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 2.67E-02 2.44E-01 1.25E+00
Immunodeficiency 4A00-4A20 Peripheral blood 1.26E-01 1.16E-01 1.06E+00
Influenza 1.00E+30 Whole blood 5.20E-02 2.62E-01 1.23E+00
Interstitial cystitis GC00.3 Bladder tissue 4.41E-03 -1.59E+00 -2.58E+00
Intracranial aneurysm 8B01.0 Intracranial artery 5.71E-01 -2.70E-01 -4.13E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 6.67E-01 -3.39E-02 -7.38E-02
Ischemic stroke 8B11 Peripheral blood 1.35E-01 1.77E-01 2.98E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 4.57E-02 1.12E-01 8.79E-02
Lateral sclerosis 8B60.4 Cervical spinal cord 1.51E-01 -2.93E-01 -6.19E-01
Lateral sclerosis 8B60.4 Skin 1.43E-01 -4.28E-01 -1.48E+00
Liver cancer 2C12.0 Liver tissue 2.93E-35 4.61E-01 2.08E+00
Liver failure DB99.7-DB99.8 Liver tissue 1.35E-02 4.30E-01 1.71E+00
Lung cancer 2C25 Lung tissue 6.30E-124 9.86E-01 3.13E+00
Lupus erythematosus 4A40 Whole blood 4.25E-10 -4.20E-01 -3.96E-01
Major depressive disorder 6A70-6A7Z Whole blood 1.85E-01 1.64E-03 2.02E-03
Major depressive disorder 6A70-6A7Z Hippocampus 9.07E-01 3.69E-02 1.67E-01
Melanoma 2C30 Skin 1.34E-04 1.31E+00 1.16E+00
Multiple myeloma 2A83.1 Bone marrow 8.32E-02 -1.93E-01 -8.69E-01
Multiple myeloma 2A83.1 Peripheral blood 1.98E-01 -4.44E-02 -3.76E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 7.93E-01 5.33E-02 2.40E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 7.09E-02 8.64E-02 2.26E-01
Myelofibrosis 2A20.2 Whole blood 4.50E-02 5.64E-01 1.19E+00
Myocardial infarction BA41-BA50 Peripheral blood 2.90E-01 3.77E-01 1.81E-01
Myopathy 8C70.6 Muscle tissue 1.21E-02 -2.97E-01 -9.39E-01
Neonatal sepsis KA60 Whole blood 1.14E-04 -5.86E-01 -7.48E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 3.71E-05 -6.31E-01 -1.89E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 2.21E-01 -1.65E-01 -5.90E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 8.87E-01 2.94E-03 5.75E-03
Olive pollen allergy CA08.00 Peripheral blood 3.20E-01 5.91E-01 8.81E-01
Oral cancer 2B6E Oral tissue 6.75E-01 -2.99E-01 -4.56E-01
Osteoarthritis FA00-FA0Z Synovial tissue 6.74E-01 1.05E-01 1.47E-01
Osteoporosis FB83.1 Bone marrow 1.62E-03 1.41E+00 3.85E+00
Ovarian cancer 2C73 Ovarian tissue 6.54E-03 1.14E+00 1.48E+00
Pancreatic cancer 2C10 Pancreas 1.14E-04 9.78E-01 1.26E+00
Parkinson's disease 8A00.0 Substantia nigra tissue 3.94E-01 1.60E-01 3.21E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 1.51E-03 3.17E-01 1.21E+00
Pituitary cancer 2D12 Pituitary tissue 1.41E-02 -3.48E-01 -7.95E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 3.77E-04 -9.02E-01 -1.72E+00
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 1.50E-01 1.46E-01 8.10E-01
Polycythemia vera 2A20.4 Whole blood 4.58E-04 4.18E-01 8.64E-01
Pompe disease 5C51.3 Biceps muscle 1.57E-04 1.16E+00 5.77E+00
Preterm birth KA21.4Z Myometrium 9.00E-01 -1.00E-01 -2.37E-01
Prostate cancer 2C82 Prostate 6.66E-02 -8.05E-01 -9.94E-01
Psoriasis EA90 Skin 3.76E-02 -1.46E-01 -2.33E-01
Rectal cancer 2B92 Rectal colon tissue 3.90E-02 -4.23E-01 -1.04E+00
Renal cancer 2C90-2C91 Kidney 9.76E-03 4.69E-01 9.29E-01
Retinoblastoma 2D02.2 Uvea 4.65E-11 1.43E+00 8.13E+00
Rheumatoid arthritis FA20 Synovial tissue 4.79E-03 5.50E-01 1.30E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 7.71E-02 8.96E-02 1.67E-01
Schizophrenia 6A20 Prefrontal cortex 4.70E-01 -6.65E-03 -1.07E-02
Schizophrenia 6A20 Superior temporal cortex 4.92E-01 -4.72E-02 -2.25E-01
Scleroderma 4A42.Z Whole blood 5.90E-01 -1.67E-02 -2.89E-02
Seizure 8A60-8A6Z Whole blood 4.21E-02 -4.23E-01 -5.83E-01
Sensitive skin EK0Z Skin 6.06E-01 -4.18E-02 -2.98E-01
Sepsis with septic shock 1G41 Whole blood 3.41E-06 -4.58E-01 -7.44E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 3.41E-02 6.40E-01 1.16E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 8.98E-03 2.21E-01 1.06E+00
Simpson golabi behmel syndrome LD2C Adipose tissue 6.39E-03 8.91E-01 4.46E+00
Sjogren's syndrome 4A43.2 Salivary gland tissue 8.45E-01 -1.71E-01 -4.63E-01
Skin cancer 2C30-2C3Z Skin 1.01E-09 4.01E-01 5.42E-01
Thrombocythemia 3B63 Whole blood 2.07E-01 3.34E-01 6.74E-01
Thrombocytopenia 3B64 Whole blood 5.42E-01 6.80E-02 2.33E-01
Thyroid cancer 2D10 Thyroid 8.41E-15 2.23E-01 7.95E-01
Tibial muscular dystrophy 8C75 Muscle tissue 9.14E-02 -1.85E-01 -2.19E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 3.51E-01 -2.06E-01 -2.25E+00
Type 2 diabetes 5A11 Liver tissue 1.13E-01 -5.38E-02 -5.31E-01
Ureter cancer 2C92 Urothelium 1.52E-01 4.14E-02 2.15E-01
Uterine cancer 2C78 Endometrium tissue 1.88E-01 -5.68E-02 -7.25E-02
Vitiligo ED63.0 Skin 3.04E-01 -1.59E-01 -7.13E-01
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⏷ Show the Full List of Expression Under 107 Diseases

The Drug Therapeutic Target (DTT) Role of This DTP

DTP DTT Name Solute carrier family 6 member 8 (SLC6A8) DTT Info
DTP DTT Type Clinical trial
1 Clinical Trial Drug(s) Targeting This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
RGX-202 DM8VGRX Gastrointestinal cancer 2C11 Phase 1 [1]
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References

1 Clinical pipeline report, company report or official report of Rgenix.
2 Astrocytic -aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain. 2018 Feb;113:1-7.