Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTR462N)

• DTP Name: Sodium/hydrogen exchanger 9B1 (SLC9B1)
• Gene Name: SLC9B1
• UniProt ID: Q4ZJI4 (SL9B1_HUMAN)
• VARIDT ID: DTD0495
• Synonyms: NHA1; NHE domain-containing protein 1; NHEDC1; Na(+)/H(+) exchanger-like domain-containing protein 1; SLC9B1; Sodium/hydrogen exchanger-like domain-containing protein 1; Solute carrier family 9, subfamily B member 1
• DTP Family: Monovalent Cation:Proton Antiporter-1 (CPA1) family
• Tissue Specificity: Expressed only in the testis.
• Sequence:
  MHTTESKNEHLEDENFQTSTTPQSLIDPNNTAQEETKTVLSDTEEIKPQTKKETYISCPL
  RGVLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLV
  PPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILRSIALTIILIRAGLGLDPQALRHL
  KVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLLGFVLGAVSPAVVVPYMMVLQENG
  YGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSGGILNNAIASIRNVCISLLAGIVL
  GFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQ
  EKMKVQKIITTVWDIFQPLLFGLVGAEVSVSSLESNIVGISVATLSLALCVRILTTYLLM
  CFAGFSFKEKIFIALAWMPKATVQAVLGPLALETARVSAPHLEPYAKDVMTVAFLAILIT
  APNGALLMGILGPKMLTRHYDPSKIKLQLSTLEHH
• Function: This transporter is involved in sperm motility and fertility. Sperm-specific Na(+)/H(+) exchanger gets involved in intracellular pH regulation of spermatozoa.
• Endogenous Substrate(s): Cations; H+
• TCDB ID: 2.A.36.2.3
• Gene ID: 150159
• Reactome Pathway: Stimuli-sensing channels (R-HSA-2672351)