Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTRL7OG)

DTP Name	Voltage-dependent calcium channel gamma-2 (CACNG2)
Gene Name	CACNG2
UniProt ID	Q9Y698 (CCG2_HUMAN)
VARIDT ID	DTD0523
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Synonyms	CACNG2; MRD10; Neuronal voltage-gated calcium channel gamma-2 subunit; TARP gamma-2; Transmembrane AMPAR regulatory protein gamma-2; Voltage-dependent calcium channel gamma-2 subunit
DTP Family	Ca(+) Channel Auxiliary Subunit Gama1-Gama8 (CCAgama) Family ;
Tissue Specificity	Expressed in brain.
Sequence	MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTH SGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGL CIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSF YFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSS SRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVH NCIQKENKDSLHSNTANRRTTPV
Function	This transporter regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.
Endogenous Substrate(s)	Ca2+
TCDB ID	8.A.16.2.1
Gene ID	10369
KEGG Pathway	MAPK signaling pathway (hsa04010 ) Cardiac muscle contraction (hsa04260 ) Adrenergic signaling in cardiomyocytes (hsa04261 ) Oxytocin signaling pathway (hsa04921 ) Hypertrophic cardiomyopathy (hsa05410 ) Arrhythmogenic right ventricular cardiomyopathy (hsa05412 ) Dilated cardiomyopathy (hsa05414 )
Reactome Pathway	Trafficking of AMPA receptors (R-HSA-399719 ) LGI-ADAM interactions (R-HSA-5682910 ) Presynaptic depolarization and calcium channel opening (R-HSA-112308 )