Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTT3SXN)

DTP Name Progressive ankylosis protein homolog (SLC62A1)
Gene Name SLC62A1
UniProt ID
Q9HCJ1 (ANKH_HUMAN)
VARIDT ID
DTD0433
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms ANK; ANKH; CCAL2; CMDJ; CPPDD; HANK; KIAA1581; MANK; SLC62A1; UNQ241/PRO274
DTP Family Multidrug/Oligosaccharidyl-Lipid/Polysaccharide (MOP) Flippase Superfamily
Progressive Ankylosis (ANK) Family
Sequence
MVKFPALTHYWPLIRFLVPLGITNIAIDFGEQALNRGIAAVKEDAVEMLASYGLAYSLMK
FFTGPMSDFKNVGLVFVNSKRDRTKAVLCMVVAGAIAAVFHTLIAYSDLGYYIINKLHHV
DESVGSKTRRAFLYLAAFPFMDAMAWTHAGILLKHKYSFLVGCASISDVIAQVVFVAILL
HSHLECREPLLIPILSLYMGALVRCTTLCLGYYKNIHDIIPDRSGPELGGDATIRKMLSF
WWPLALILATQRISRPIVNLFVSRDLGGSSAATEAVAILTATYPVGHMPYGWLTEIRAVY
PAFDKNNPSNKLVSTSNTVTAAHIKKFTFVCMALSLTLCFVMFWTPNVSEKILIDIIGVD
FAFAELCVVPLRIFSFFPVPVTVRAHLTGWLMTLKKTFVLAPSSVLRIIVLIASLVVLPY
LGVHGATLGVGSLLAGFVGESTMVAIAACYVYRKQKKKMENESATEGEDSAMTDMPPTEE
VTDIVEMREENE
Function This transporter probably function as PPi transporter.
Endogenous Substrate(s) Pyrophosphate
TCDB ID
2.A.66.9.1
Gene ID
56172
Reactome Pathway
Miscellaneous transport and binding events (R-HSA-5223345 )

Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 4.23E-39 -8.60E-01 -2.55E+00
Adrenocortical carcinoma 2D11.Z Kidney 1.86E-02 -4.11E-01 -9.09E-01
Alopecia ED70 Skin from scalp 1.63E-01 -7.81E-02 -3.98E-01
Alzheimer's disease 8A20 Entorhinal cortex 2.35E-03 -2.65E-01 -6.29E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 8.42E-02 -5.01E-02 -3.09E-01
Aortic stenosis BB70 Calcified aortic valve 6.93E-01 -4.03E-02 -1.04E-01
Apnea 7A40 Hyperplastic tonsil 7.69E-01 2.63E-02 2.28E-01
Arthropathy FA00-FA5Z Peripheral blood 1.98E-01 -1.88E-01 -6.87E-01
Asthma CA23 Nasal and bronchial airway 3.20E-07 -3.14E-01 -6.06E-01
Atopic dermatitis EA80 Skin 8.46E-12 -3.72E-01 -2.28E+00
Autism 6A02 Whole blood 9.04E-01 -2.15E-02 -7.09E-02
Autoimmune uveitis 9A96 Peripheral monocyte 1.46E-01 -2.65E-01 -1.10E+00
Autosomal dominant monocytopenia 4B04 Whole blood 1.37E-02 -4.81E-01 -1.46E+00
Bacterial infection of gingival 1C1H Gingival tissue 1.47E-09 -2.77E-01 -8.56E-01
Batten disease 5C56.1 Whole blood 7.07E-01 -4.61E-02 -1.90E-01
Behcet's disease 4A62 Peripheral blood 4.05E-01 -6.21E-02 -3.52E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 3.82E-01 -7.00E-02 -2.87E-01
Bladder cancer 2C94 Bladder tissue 7.54E-01 -8.04E-02 -3.63E-01
Breast cancer 2C60-2C6Z Breast tissue 5.16E-28 -4.69E-01 -1.25E+00
Cardioembolic stroke 8B11.20 Whole blood 8.29E-01 -1.40E-01 -3.40E-01
Cervical cancer 2C77 Cervical tissue 2.31E-01 -1.85E-01 -4.94E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 3.61E-01 -1.94E-01 -4.38E-01
Chronic hepatitis C 1E51.1 Whole blood 7.79E-01 -1.43E-02 -6.36E-02
Chronic obstructive pulmonary disease CA22 Lung tissue 8.93E-01 1.10E-02 4.76E-02
Chronic obstructive pulmonary disease CA22 Small airway epithelium 1.73E-02 -7.73E-02 -3.15E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 2.28E-01 2.30E-01 7.31E-01
Colon cancer 2B90 Colon tissue 3.19E-04 6.62E-02 2.23E-01
Coronary artery disease BA80-BA8Z Peripheral blood 3.34E-01 -1.97E-01 -8.12E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 5.59E-01 -4.28E-02 -2.52E-01
Endometriosis GA10 Endometrium tissue 9.89E-01 1.40E-01 1.86E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 9.85E-01 -1.95E-02 -7.99E-02
Familial hypercholesterolemia 5C80.00 Whole blood 1.13E-07 -7.34E-01 -1.94E+00
Gastric cancer 2B72 Gastric tissue 1.17E-01 1.50E-01 9.48E-01
Glioblastopma 2A00.00 Nervous tissue 1.18E-84 -8.81E-01 -1.61E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 3.86E-03 3.64E-01 1.02E+00
Head and neck cancer 2D42 Head and neck tissue 6.84E-10 3.05E-01 7.36E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 8.01E-02 -1.88E-01 -6.46E-01
Huntington's disease 8A01.10 Whole blood 2.84E-01 1.10E-01 6.07E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 1.72E-01 1.02E-01 6.17E-01
Immunodeficiency 4A00-4A20 Peripheral blood 9.54E-02 -5.63E-02 -6.24E-01
Influenza 1.00E+30 Whole blood 8.25E-01 -2.56E-01 -5.06E-01
Interstitial cystitis GC00.3 Bladder tissue 7.50E-01 8.50E-02 4.24E-01
Intracranial aneurysm 8B01.0 Intracranial artery 5.14E-03 7.83E-01 1.70E+00
Irritable bowel syndrome DD91.0 Rectal colon tissue 8.82E-01 -3.35E-02 -1.26E-01
Ischemic stroke 8B11 Peripheral blood 3.14E-01 -2.46E-02 -8.55E-02
Juvenile idiopathic arthritis FA24 Peripheral blood 1.37E-02 -1.56E-01 -4.48E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 1.53E-01 -1.37E-01 -5.93E-01
Lateral sclerosis 8B60.4 Skin 8.83E-01 3.22E-02 1.31E-01
Liver cancer 2C12.0 Liver tissue 4.75E-01 -1.14E-01 -2.83E-01
Liver failure DB99.7-DB99.8 Liver tissue 5.72E-01 -1.67E-01 -4.79E-01
Lung cancer 2C25 Lung tissue 9.03E-10 5.40E-02 1.84E-01
Lupus erythematosus 4A40 Whole blood 6.55E-10 -3.03E-01 -5.11E-01
Major depressive disorder 6A70-6A7Z Whole blood 8.94E-01 -2.06E-02 -5.62E-02
Major depressive disorder 6A70-6A7Z Hippocampus 5.77E-01 -3.84E-02 -1.68E-01
Melanoma 2C30 Skin 1.68E-03 -4.69E-01 -7.93E-01
Multiple myeloma 2A83.1 Bone marrow 2.97E-02 -1.51E-01 -9.16E-01
Multiple myeloma 2A83.1 Peripheral blood 4.43E-01 -3.60E-02 -2.02E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 2.29E-01 1.13E-01 3.94E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 6.78E-01 7.88E-02 2.71E-01
Myelofibrosis 2A20.2 Whole blood 4.99E-01 -9.18E-02 -3.85E-01
Myocardial infarction BA41-BA50 Peripheral blood 1.30E-04 -4.01E-01 -7.96E-01
Myopathy 8C70.6 Muscle tissue 6.93E-02 -1.35E-01 -4.00E-01
Neonatal sepsis KA60 Whole blood 2.42E-04 -1.59E-01 -4.12E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 2.45E-01 6.31E-02 1.59E-01
Non-alcoholic fatty liver disease DB92 Liver tissue 5.08E-01 -3.57E-02 -2.29E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 4.06E-01 -4.06E-02 -2.80E-01
Olive pollen allergy CA08.00 Peripheral blood 3.67E-01 2.06E-01 5.20E-01
Oral cancer 2B6E Oral tissue 5.52E-01 5.90E-02 1.94E-01
Osteoarthritis FA00-FA0Z Synovial tissue 9.12E-02 3.95E-01 5.48E-01
Osteoporosis FB83.1 Bone marrow 9.55E-02 -3.23E-01 -3.92E-01
Ovarian cancer 2C73 Ovarian tissue 1.56E-02 -4.59E-01 -6.72E-01
Pancreatic cancer 2C10 Pancreas 5.65E-01 -3.18E-02 -7.16E-02
Parkinson's disease 8A00.0 Substantia nigra tissue 9.38E-01 -3.62E-01 -7.72E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 6.83E-02 -1.40E-01 -4.51E-01
Pituitary cancer 2D12 Pituitary tissue 4.24E-01 -5.84E-02 -1.76E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 5.39E-01 -1.68E-01 -4.08E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 6.76E-02 8.80E-02 4.44E-01
Polycythemia vera 2A20.4 Whole blood 5.85E-02 -1.61E-01 -6.82E-01
Pompe disease 5C51.3 Biceps muscle 1.70E-02 -5.01E-01 -2.15E+00
Preterm birth KA21.4Z Myometrium 7.29E-01 6.97E-02 1.93E-01
Prostate cancer 2C82 Prostate 3.98E-01 2.01E-01 3.89E-01
Psoriasis EA90 Skin 2.57E-08 -2.44E-01 -5.85E-01
Rectal cancer 2B92 Rectal colon tissue 2.91E-02 2.97E-01 8.03E-01
Renal cancer 2C90-2C91 Kidney 3.89E-03 1.66E-01 8.33E-01
Retinoblastoma 2D02.2 Uvea 3.08E-09 -1.78E+00 -4.25E+00
Rheumatoid arthritis FA20 Synovial tissue 2.84E-01 8.64E-02 9.79E-02
Rhinovirus infection CA42.1 Nasal epithelium tissue 1.80E-02 6.73E-02 5.38E-01
Schizophrenia 6A20 Prefrontal cortex 2.13E-02 -1.86E-01 -3.27E-01
Schizophrenia 6A20 Superior temporal cortex 5.75E-01 -1.61E-02 -3.48E-02
Scleroderma 4A42.Z Whole blood 5.02E-05 -6.78E-01 -2.72E+00
Seizure 8A60-8A6Z Whole blood 6.66E-01 -4.54E-03 -1.32E-02
Sensitive skin EK0Z Skin 2.57E-01 -1.94E-01 -1.31E+00
Sepsis with septic shock 1G41 Whole blood 1.89E-08 -1.55E-01 -5.45E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 3.36E-01 2.47E-01 9.22E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 9.36E-01 3.96E-03 2.99E-02
Simpson golabi behmel syndrome LD2C Adipose tissue 6.34E-01 1.38E-02 9.66E-02
Sjogren's syndrome 4A43.2 Salivary gland tissue 4.31E-01 1.37E-01 5.79E-01
Skin cancer 2C30-2C3Z Skin 7.80E-22 -7.18E-01 -1.87E+00
Thrombocythemia 3B63 Whole blood 3.13E-01 -1.46E-01 -6.38E-01
Thrombocytopenia 3B64 Whole blood 4.03E-01 -1.14E-01 -2.21E-01
Thyroid cancer 2D10 Thyroid 2.59E-02 -2.65E-02 -8.21E-02
Tibial muscular dystrophy 8C75 Muscle tissue 9.35E-01 2.18E-01 6.86E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 2.56E-03 -5.48E-01 -7.28E+00
Type 2 diabetes 5A11 Liver tissue 6.87E-01 -9.90E-02 -5.21E-01
Ureter cancer 2C92 Urothelium 5.81E-01 6.76E-02 4.65E-01
Uterine cancer 2C78 Endometrium tissue 6.18E-01 -7.82E-02 -2.02E-01
Vitiligo ED63.0 Skin 7.78E-01 2.01E-02 6.99E-02
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