Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTV8JXE)

DTP Name Sodium/hydrogen exchanger 2 (SLC9A2)
Gene Name SLC9A2
UniProt ID
Q9UBY0 (SL9A2_HUMAN)
VARIDT ID
DTD0482
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms NHE-2; NHE2; Na(+)/H(+) exchanger 2; SLC9A2; Solute carrier family 9 member 2
DTP Family Monovalent Cation:Proton Antiporter-1 (CPA1) family ;
Tissue Specificity Expressed in skeletal muscle, colon andkidney. Lower levels in the testis, prostate, ovary, and smallintestine.
Sequence
MEPLGNWRSLRAPLPPMLLLLLLQVAGPVGALAETLLNAPRAMGTSSSPPSPASVVAPGT
TLFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLL
LGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWN
SIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVF
GESLLNDAVTVVLYNLFKSFCQMKTIETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFTT
RFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIK
YFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLMWRALGVFVLTQVINRFR
TIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIR
PLVEFLDVKRSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRK
LLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDE
IRELLSRNLYQIRQRTLSYNRHSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHRA
STSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTVLNLQPRARRFLPEQFS
KKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSEREDS
LTEGIPPKPPPRLVWRASEPGSRKARFGSEKP
Function This transporter mediates and participates in regulating pH value to eliminate acids generated by active metabolism or to combat adverse environmental conditions.
Endogenous Substrate(s) Na+; H+
TCDB ID
2.A.36.1.17
Gene ID
6549
Reactome Pathway
Sodium/Proton exchangers (R-HSA-425986 )

Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 6.31E-01 -9.86E-03 -4.69E-02
Adrenocortical carcinoma 2D11.Z Kidney 5.36E-01 -4.93E-02 -2.36E-01
Alopecia ED70 Skin from scalp 4.39E-02 -5.93E-02 -3.16E-01
Alzheimer's disease 8A20 Entorhinal cortex 9.52E-02 -5.57E-02 -3.42E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 2.84E-01 2.33E-02 2.76E-01
Aortic stenosis BB70 Calcified aortic valve 5.44E-01 1.22E-01 3.64E-01
Apnea 7A40 Hyperplastic tonsil 2.05E-01 -1.15E-01 -7.05E-01
Arthropathy FA00-FA5Z Peripheral blood 1.74E-01 2.36E-02 1.75E-01
Asthma CA23 Nasal and bronchial airway 1.59E-03 -1.15E-01 -4.63E-01
Atopic dermatitis EA80 Skin 2.25E-01 -1.41E-01 -1.03E+00
Autism 6A02 Whole blood 7.57E-01 3.53E-02 2.24E-01
Autoimmune uveitis 9A96 Peripheral monocyte 5.30E-01 2.05E-02 1.70E-01
Autosomal dominant monocytopenia 4B04 Whole blood 7.58E-01 6.59E-02 4.84E-01
Bacterial infection of gingival 1C1H Gingival tissue 3.31E-01 -1.24E-02 -5.75E-02
Batten disease 5C56.1 Whole blood 5.18E-01 6.60E-03 1.25E-01
Behcet's disease 4A62 Peripheral blood 6.98E-02 9.24E-02 1.26E+00
Bipolar disorder 6A60-6A6Z Prefrontal cortex 6.18E-01 -7.69E-02 -4.54E-01
Bladder cancer 2C94 Bladder tissue 8.22E-03 1.37E-01 7.05E-01
Breast cancer 2C60-2C6Z Breast tissue 8.26E-05 -1.84E-02 -9.66E-02
Cardioembolic stroke 8B11.20 Whole blood 2.63E-01 2.52E-02 1.69E-01
Cervical cancer 2C77 Cervical tissue 3.92E-01 -2.87E-02 -2.04E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 9.88E-01 1.75E-02 6.71E-02
Chronic hepatitis C 1E51.1 Whole blood 2.93E-01 9.59E-02 8.47E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 5.00E-01 9.56E-02 4.84E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 2.22E-03 1.06E-01 6.53E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 2.06E-01 1.34E-01 1.48E+00
Colon cancer 2B90 Colon tissue 1.56E-80 -1.10E+00 -3.02E+00
Coronary artery disease BA80-BA8Z Peripheral blood 8.72E-02 -2.46E-01 -9.51E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 8.32E-01 -1.97E-02 -1.26E-01
Endometriosis GA10 Endometrium tissue 7.43E-01 -1.39E-02 -7.54E-02
Familial hypercholesterolemia 5C80.00 Peripheral blood 7.92E-01 -2.88E-02 -1.61E-01
Familial hypercholesterolemia 5C80.00 Whole blood 5.93E-02 -1.11E-01 -6.59E-01
Gastric cancer 2B72 Gastric tissue 5.78E-02 -7.50E-01 -2.67E+00
Glioblastopma 2A00.00 Nervous tissue 3.32E-60 -2.05E-01 -1.03E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 2.44E-11 -6.93E-01 -4.88E+00
Head and neck cancer 2D42 Head and neck tissue 8.00E-01 -2.18E-02 -1.32E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 1.32E-01 -1.07E-01 -5.94E-01
Huntington's disease 8A01.10 Whole blood 4.34E-01 1.93E-01 9.01E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 3.93E-01 -5.31E-02 -2.96E-01
Immunodeficiency 4A00-4A20 Peripheral blood 7.72E-02 4.19E-02 6.00E-01
Influenza 1.00E+30 Whole blood 1.36E-02 2.82E-01 3.48E+00
Interstitial cystitis GC00.3 Bladder tissue 6.74E-04 -2.20E-01 -2.62E+00
Intracranial aneurysm 8B01.0 Intracranial artery 2.99E-01 -1.18E-01 -6.77E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 1.60E-01 5.50E-03 2.60E-02
Ischemic stroke 8B11 Peripheral blood 1.08E-02 1.29E-01 8.99E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 9.93E-02 5.24E-02 2.04E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 1.10E-01 -1.65E-01 -6.50E-01
Lateral sclerosis 8B60.4 Skin 9.05E-01 3.55E-03 1.66E-02
Liver cancer 2C12.0 Liver tissue 1.18E-06 -1.79E-01 -9.38E-01
Liver failure DB99.7-DB99.8 Liver tissue 6.30E-01 3.30E-03 1.58E-02
Lung cancer 2C25 Lung tissue 4.74E-09 5.37E-02 3.34E-01
Lupus erythematosus 4A40 Whole blood 1.51E-01 -3.81E-02 -1.47E-01
Major depressive disorder 6A70-6A7Z Whole blood 6.74E-01 4.34E-03 2.09E-02
Major depressive disorder 6A70-6A7Z Hippocampus 8.57E-01 -2.78E-02 -1.72E-01
Melanoma 2C30 Skin 1.03E-04 -1.12E-01 -4.85E-01
Multiple myeloma 2A83.1 Bone marrow 4.93E-01 -7.39E-02 -5.28E-01
Multiple myeloma 2A83.1 Peripheral blood 4.96E-01 -7.98E-04 -7.60E-03
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 4.11E-01 7.42E-02 2.28E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 1.28E-01 -1.64E-02 -2.29E-01
Myelofibrosis 2A20.2 Whole blood 4.79E-01 4.04E-02 2.97E-01
Myocardial infarction BA41-BA50 Peripheral blood 1.28E-02 1.88E-01 7.20E-01
Myopathy 8C70.6 Muscle tissue 4.95E-02 -2.13E-01 -1.03E+00
Neonatal sepsis KA60 Whole blood 1.35E-01 -4.21E-02 -1.78E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 1.17E-01 -1.03E-01 -4.70E-01
Non-alcoholic fatty liver disease DB92 Liver tissue 6.34E-01 -7.59E-02 -8.91E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 5.37E-01 5.51E-02 5.44E-01
Olive pollen allergy CA08.00 Peripheral blood 1.83E-01 1.77E-01 1.35E+00
Oral cancer 2B6E Oral tissue 1.74E-02 -2.26E-01 -1.08E+00
Osteoarthritis FA00-FA0Z Synovial tissue 9.81E-02 -1.50E-01 -6.73E-01
Osteoporosis FB83.1 Bone marrow 3.17E-02 1.67E-01 1.35E+00
Ovarian cancer 2C73 Ovarian tissue 3.87E-01 6.92E-02 4.69E-01
Pancreatic cancer 2C10 Pancreas 9.09E-01 -1.83E-01 -3.53E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 2.68E-01 -3.75E-02 -1.99E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 9.16E-01 -1.40E-02 -1.95E-01
Pituitary cancer 2D12 Pituitary tissue 3.07E-02 1.57E-01 9.29E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 1.84E-01 1.50E-01 1.01E+00
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 4.47E-01 -1.60E-02 -2.28E-01
Polycythemia vera 2A20.4 Whole blood 2.52E-02 9.67E-02 7.73E-01
Pompe disease 5C51.3 Biceps muscle 9.94E-01 -6.33E-03 -4.88E-02
Preterm birth KA21.4Z Myometrium 8.05E-01 4.24E-02 2.03E-01
Prostate cancer 2C82 Prostate 3.56E-01 9.98E-02 1.63E-01
Psoriasis EA90 Skin 2.30E-15 -3.17E-01 -1.15E+00
Rectal cancer 2B92 Rectal colon tissue 4.70E-06 -6.93E-01 -4.30E+00
Renal cancer 2C90-2C91 Kidney 4.84E-04 -2.65E-01 -1.65E+00
Retinoblastoma 2D02.2 Uvea 1.28E-03 -1.51E-01 -1.26E+00
Rheumatoid arthritis FA20 Synovial tissue 3.19E-03 -4.50E-01 -1.44E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 9.71E-01 -3.54E-02 -1.99E-01
Schizophrenia 6A20 Prefrontal cortex 9.16E-01 -5.63E-02 -2.79E-01
Schizophrenia 6A20 Superior temporal cortex 8.08E-01 2.15E-02 2.07E-01
Scleroderma 4A42.Z Whole blood 1.79E-02 1.19E-01 1.22E+00
Seizure 8A60-8A6Z Whole blood 9.95E-01 1.27E-02 8.68E-02
Sensitive skin EK0Z Skin 7.56E-01 2.86E-03 3.39E-02
Sepsis with septic shock 1G41 Whole blood 1.36E-04 6.47E-02 2.71E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 3.85E-03 2.91E-01 2.13E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 2.18E-01 9.39E-02 5.18E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 3.95E-01 1.60E-01 1.03E+00
Sjogren's syndrome 4A43.2 Salivary gland tissue 1.63E-01 8.69E-02 8.93E-01
Skin cancer 2C30-2C3Z Skin 6.70E-32 -3.33E-01 -1.01E+00
Thrombocythemia 3B63 Whole blood 8.82E-01 6.04E-02 4.07E-01
Thrombocytopenia 3B64 Whole blood 7.52E-01 -3.89E-02 -2.05E-01
Thyroid cancer 2D10 Thyroid 2.38E-05 9.35E-02 4.96E-01
Tibial muscular dystrophy 8C75 Muscle tissue 1.08E-06 -4.32E-01 -2.27E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 8.47E-01 9.38E-02 7.37E-01
Type 2 diabetes 5A11 Liver tissue 9.12E-01 1.64E-02 1.20E-01
Ureter cancer 2C92 Urothelium 2.34E-01 1.11E-01 5.92E-01
Uterine cancer 2C78 Endometrium tissue 2.63E-16 2.22E-01 9.06E-01
Vitiligo ED63.0 Skin 1.11E-02 -1.81E-01 -1.09E+00
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