Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTVFLQD)

DTP Name	Voltage-dependent calcium channel gamma-3 (CACNG3)
Gene Name	CACNG3
UniProt ID	O60359 (CCG3_HUMAN)
VARIDT ID	DTD0524
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Synonyms	CACNG3; Neuronal voltage-gated calcium channel gamma-3 subunit; TARP gamma-3; Transmembrane AMPAR regulatory protein gamma-3; Voltage-dependent calcium channel gamma-3 subunit
DTP Family	Ca(+) Channel Auxiliary Subunit Gama1-Gama8 (CCAgama) Family ;
Sequence	MRMCDRGIQMLITTVGAFAAFSLMTIAVGTDYWLYSRGVCRTKSTSDNETSRKNEEVMTH SGLWRTCCLEGAFRGVCKKIDHFPEDADYEQDTAEYLLRAVRASSVFPILSVTLLFFGGL CVAASEFHRSRHNVILSAGIFFVSAGLSNIIGIIVYISANAGDPGQRDSKKSYSYGWSFY FGAFSFIIAEIVGVVAVHIYIEKHQQLRAKSHSEFLKKSTFARLPPYRYRFRRRSSSRST EPRSRDLSPISKGFHTIPSTDISMFTLSRDPSKITMGTLLNSDRDHAFLQFHNSTPKEFK ESLHNNPANRRTTPV
Function	This transporter regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.
Endogenous Substrate(s)	Ca2+
TCDB ID	8.A.16.2.2
Gene ID	10368
KEGG Pathway	MAPK signaling pathway (hsa04010 ) Cardiac muscle contraction (hsa04260 ) Adrenergic signaling in cardiomyocytes (hsa04261 ) Oxytocin signaling pathway (hsa04921 ) Hypertrophic cardiomyopathy (hsa05410 ) Arrhythmogenic right ventricular cardiomyopathy (hsa05412 ) Dilated cardiomyopathy (hsa05414 )
Reactome Pathway	LGI-ADAM interactions (R-HSA-5682910 ) Trafficking of AMPA receptors (R-HSA-399719 )