Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTXQYLR)

DTP Name Vesicular inhibitory amino acid transporter (SLC32A1)
Gene Name SLC32A1
UniProt ID
Q9H598 (VIAAT_HUMAN)
VARIDT ID
DTD0281
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms GABA and glycine transporter; SLC32A1; Solute carrier family 32 member 1; VGAT; VIAAT; Vesicular GABA transporter; hVIAAT
DTP Family Amino Acid/Auxin Permease (AAAP) Family ;
Tissue Specificity Retina. Expressed throughout the horizontalcells or more specifically at the terminals.
Sequence
MATLLRSKLSNVATSVSNKSQAKMSGMFARMGFQAATDEEAVGFAHCDDLDFEHRQGLQM
DILKAEGEPCGDEGAEAPVEGDIHYQRGSGAPLPPSGSKDQVGGGGEFGGHDKPKITAWE
AGWNVTNAIQGMFVLGLPYAILHGGYLGLFLIIFAAVVCCYTGKILIACLYEENEDGEVV
RVRDSYVAIANACCAPRFPTLGGRVVNVAQIIELVMTCILYVVVSGNLMYNSFPGLPVSQ
KSWSIIATAVLLPCAFLKNLKAVSKFSLLCTLAHFVINILVIAYCLSRARDWAWEKVKFY
IDVKKFPISIGIIVFSYTSQIFLPSLEGNMQQPSEFHCMMNWTHIAACVLKGLFALVAYL
TWADETKEVITDNLPGSIRAVVNIFLVAKALLSYPLPFFAAVEVLEKSLFQEGSRAFFPA
CYSGDGRLKSWGLTLRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLRL
LWRKLLWHQVFFDVAIFVIGGICSVSGFVHSLEGLIEAYRTNAED
Function This transporter is involved in the uptake of GABA and glycine into the synaptic vesicles.
Endogenous Substrate(s) Amino acids; H+
TCDB ID
2.A.18.5.4
Gene ID
140679
KEGG Pathway
Synaptic vesicle cycle (hsa04721 )
Retrograde endocannabinoid signaling (hsa04723 )
GABAergic synapse (hsa04727 )
Morphine addiction (hsa05032 )
Nicotine addiction (hsa05033 )
Reactome Pathway
GABA synthesis, release, reuptake and degradation (R-HSA-888590 )
Transport of inorganic cations/anions and amino acids/oligopeptides (R-HSA-425393 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
1 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
GSK683699 DMTW79H Inflammatory bowel disease DD72 Phase 2 [1]
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Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 3.49E-03 -7.60E-02 -3.85E-01
Adrenocortical carcinoma 2D11.Z Kidney 5.59E-01 -4.53E-02 -2.34E-01
Alopecia ED70 Skin from scalp 4.64E-01 -5.28E-02 -2.62E-01
Alzheimer's disease 8A20 Entorhinal cortex 1.45E-07 -7.17E-01 -8.82E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 1.87E-01 -2.58E-02 -2.08E-01
Aortic stenosis BB70 Calcified aortic valve 8.33E-01 -2.08E-01 -3.14E-01
Apnea 7A40 Hyperplastic tonsil 9.06E-01 4.33E-02 6.67E-01
Arthropathy FA00-FA5Z Peripheral blood 4.23E-01 1.95E-03 1.95E-02
Asthma CA23 Nasal and bronchial airway 1.99E-02 -8.27E-02 -2.37E-01
Atopic dermatitis EA80 Skin 9.01E-01 1.15E-02 1.70E-01
Autism 6A02 Whole blood 4.26E-01 -4.31E-02 -2.53E-01
Autoimmune uveitis 9A96 Peripheral monocyte 1.88E-01 -1.23E-01 -9.25E-01
Autosomal dominant monocytopenia 4B04 Whole blood 9.91E-01 7.43E-03 4.43E-02
Bacterial infection of gingival 1C1H Gingival tissue 7.03E-03 5.52E-02 3.16E-01
Batten disease 5C56.1 Whole blood 3.94E-01 5.53E-02 1.22E+00
Behcet's disease 4A62 Peripheral blood 5.68E-01 2.59E-02 1.35E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 3.70E-02 -8.95E-02 -1.89E-01
Bladder cancer 2C94 Bladder tissue 6.87E-01 3.55E-03 1.51E-02
Breast cancer 2C60-2C6Z Breast tissue 5.33E-01 -9.04E-03 -3.95E-02
Cardioembolic stroke 8B11.20 Whole blood 8.81E-01 1.08E-02 5.85E-02
Cervical cancer 2C77 Cervical tissue 3.37E-01 -4.24E-02 -2.41E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 4.37E-01 7.38E-02 3.60E-01
Chronic hepatitis C 1E51.1 Whole blood 6.12E-01 1.35E-02 5.88E-02
Chronic obstructive pulmonary disease CA22 Lung tissue 6.11E-01 -1.15E-02 -6.49E-02
Chronic obstructive pulmonary disease CA22 Small airway epithelium 2.90E-01 7.21E-02 4.24E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 6.50E-01 -3.52E-02 -4.95E-01
Colon cancer 2B90 Colon tissue 1.35E-02 -5.08E-02 -2.76E-01
Coronary artery disease BA80-BA8Z Peripheral blood 1.22E-01 7.77E-02 1.76E+00
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 6.21E-02 -1.78E-01 -5.91E-01
Endometriosis GA10 Endometrium tissue 1.10E-01 3.67E-02 3.05E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 8.39E-01 -6.58E-02 -4.92E-01
Familial hypercholesterolemia 5C80.00 Whole blood 1.67E-02 -1.74E-01 -9.35E-01
Gastric cancer 2B72 Gastric tissue 7.75E-01 5.88E-03 8.38E-02
Glioblastopma 2A00.00 Nervous tissue 1.69E-121 -2.57E+00 -2.19E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 1.64E-02 -3.63E-01 -1.51E+00
Head and neck cancer 2D42 Head and neck tissue 1.85E-01 -1.68E-02 -1.04E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 3.18E-01 -9.51E-01 -8.71E-01
Huntington's disease 8A01.10 Whole blood 9.26E-01 2.89E-02 1.52E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 9.11E-01 2.78E-02 2.57E-01
Immunodeficiency 4A00-4A20 Peripheral blood 1.66E-01 7.93E-02 9.09E-01
Influenza 1.00E+30 Whole blood 3.19E-01 -1.55E-01 -6.89E-01
Interstitial cystitis GC00.3 Bladder tissue 8.59E-02 7.01E-02 5.15E-01
Intracranial aneurysm 8B01.0 Intracranial artery 9.33E-01 -3.67E-02 -1.55E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 2.95E-01 1.93E-02 7.72E-02
Ischemic stroke 8B11 Peripheral blood 1.68E-01 6.03E-02 5.13E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 4.81E-01 -2.91E-02 -1.30E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 9.97E-01 1.29E-01 3.34E-01
Lateral sclerosis 8B60.4 Skin 7.06E-01 -2.53E-02 -1.17E-01
Liver cancer 2C12.0 Liver tissue 7.15E-05 -1.58E-01 -7.20E-01
Liver failure DB99.7-DB99.8 Liver tissue 6.44E-01 5.65E-03 6.77E-02
Lung cancer 2C25 Lung tissue 5.61E-04 4.62E-02 2.35E-01
Lupus erythematosus 4A40 Whole blood 6.22E-01 1.49E-02 5.19E-02
Major depressive disorder 6A70-6A7Z Whole blood 1.40E-02 5.75E-02 3.19E-01
Major depressive disorder 6A70-6A7Z Hippocampus 4.59E-01 -1.46E-01 -3.21E-01
Melanoma 2C30 Skin 5.81E-02 -1.71E-01 -5.62E-01
Multiple myeloma 2A83.1 Bone marrow 4.50E-01 -9.11E-02 -4.91E-01
Multiple myeloma 2A83.1 Peripheral blood 2.25E-02 1.13E-01 8.93E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 2.56E-01 8.05E-01 1.04E+00
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 5.68E-03 -8.99E-02 -2.18E-01
Myelofibrosis 2A20.2 Whole blood 1.42E-01 1.17E-01 7.72E-01
Myocardial infarction BA41-BA50 Peripheral blood 8.47E-01 -5.01E-02 -1.99E-01
Myopathy 8C70.6 Muscle tissue 3.48E-03 -1.58E-01 -1.74E+00
Neonatal sepsis KA60 Whole blood 2.16E-02 -2.62E-02 -1.40E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 8.94E-05 -1.71E+00 -2.39E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 1.37E-01 -6.61E-02 -3.81E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 9.19E-01 3.97E-02 2.35E-01
Olive pollen allergy CA08.00 Peripheral blood 2.24E-01 8.88E-02 7.89E-01
Oral cancer 2B6E Oral tissue 2.66E-06 -1.91E-01 -1.01E+00
Osteoarthritis FA00-FA0Z Synovial tissue 9.86E-01 2.50E-02 1.21E-01
Osteoporosis FB83.1 Bone marrow 1.59E-01 7.86E-02 6.36E-01
Ovarian cancer 2C73 Ovarian tissue 4.73E-01 7.21E-03 2.45E-02
Pancreatic cancer 2C10 Pancreas 3.32E-03 -1.56E-01 -8.42E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 4.77E-01 1.04E-02 1.30E-02
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 2.67E-01 -6.32E-02 -3.67E-01
Pituitary cancer 2D12 Pituitary tissue 1.22E-02 2.92E+00 3.51E+00
Pituitary gonadotrope tumour 2D12 Pituitary tissue 6.55E-07 3.43E+00 3.66E+00
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 4.91E-01 5.64E-03 3.97E-02
Polycythemia vera 2A20.4 Whole blood 4.27E-01 3.39E-02 2.13E-01
Pompe disease 5C51.3 Biceps muscle 1.13E-01 -9.56E-02 -9.55E-01
Preterm birth KA21.4Z Myometrium 1.24E-01 -4.50E-02 -4.32E-01
Prostate cancer 2C82 Prostate 3.58E-01 4.83E-02 1.88E-01
Psoriasis EA90 Skin 4.92E-03 1.50E-02 6.51E-02
Rectal cancer 2B92 Rectal colon tissue 2.59E-01 -1.20E-01 -4.02E-01
Renal cancer 2C90-2C91 Kidney 2.24E-01 -1.85E-01 -5.75E-01
Retinoblastoma 2D02.2 Uvea 3.73E-08 -2.17E+00 -3.59E+00
Rheumatoid arthritis FA20 Synovial tissue 6.91E-02 -1.58E-01 -4.18E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 3.89E-01 1.06E-02 7.95E-02
Schizophrenia 6A20 Prefrontal cortex 7.90E-03 -8.09E-01 -5.81E-01
Schizophrenia 6A20 Superior temporal cortex 6.01E-01 -3.47E-02 -4.63E-02
Scleroderma 4A42.Z Whole blood 1.20E-01 9.85E-02 5.42E-01
Seizure 8A60-8A6Z Whole blood 9.27E-01 -1.85E-01 -8.05E-01
Sensitive skin EK0Z Skin 7.63E-01 1.55E-03 9.15E-03
Sepsis with septic shock 1G41 Whole blood 4.12E-02 -3.88E-02 -1.85E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 2.83E-01 2.47E-01 1.35E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 6.62E-02 1.14E-01 6.16E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 7.05E-01 -3.46E-02 -1.84E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 5.98E-01 -1.67E-01 -4.14E-01
Skin cancer 2C30-2C3Z Skin 3.07E-02 -3.44E-02 -1.62E-01
Thrombocythemia 3B63 Whole blood 4.28E-01 -2.24E-02 -1.39E-01
Thrombocytopenia 3B64 Whole blood 5.07E-02 1.48E-01 8.76E-01
Thyroid cancer 2D10 Thyroid 1.68E-02 7.89E-02 4.11E-01
Tibial muscular dystrophy 8C75 Muscle tissue 1.08E-02 -1.07E-01 -5.33E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 6.29E-01 2.15E-01 1.34E+00
Type 2 diabetes 5A11 Liver tissue 1.62E-01 -1.02E-01 -7.20E-01
Ureter cancer 2C92 Urothelium 6.49E-01 -2.55E-02 -1.97E-01
Uterine cancer 2C78 Endometrium tissue 3.08E-01 1.30E-02 6.33E-02
Vitiligo ED63.0 Skin 3.21E-01 -1.01E-01 -7.26E-01
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References

1 Wakefulness Is Governed by GABA and Histamine Cotransmission. Neuron. 2015 Jul 1;87(1):164-78.