Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTYDHJI)

DTP Name Adenine nucleotide translocator 4 (SLC25A31)
Gene Name SLC25A31
UniProt ID
Q9H0C2 (ADT4_HUMAN)
VARIDT ID
DTD0193
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms ADP,ATP carrier protein 4; ADP/ATP translocase 4; Solute carrier family 25 member 31; Sperm flagellar energy carrier protein; SLC25A31; AAC4; ANT4; SFEC; ANT 4
DTP Family Mitochondrial Carrier (MC) Family ;
Tissue Specificity Expressed in brain, liver, sperm and testis.
Sequence
MHREPAKKKAEKRLFDASSFGKDLLAGGVAAAVSKTAVAPIERVKLLLQVQASSKQISPE
ARYKGMVDCLVRIPREQGFFSFWRGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQ
FWRWFLANLASGGAAGATSLCVVYPLDFARTRLGVDIGKGPEERQFKGLGDCIMKIAKSD
GIAGLYQGFGVSVQGIIVYRASYFGAYDTVKGLLPKPKKTPFLVSFFIAQVVTTCSGILS
YPFDTVRRRMMMQSGEAKRQYKGTLDCFVKIYQHEGISSFFRGAFSNVLRGTGGALVLVL
YDKIKEFFHIDIGGR
Function This transporter can catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.
Endogenous Substrate(s) ADP; ATP
TCDB ID
2.A.29.1.8
Gene ID
83447
KEGG Pathway
Calcium signaling pathway (hsa04020 )
cGMP-PKG signaling pathway (hsa04022 )
Necroptosis (hsa04217 )
Cellular senescence (hsa04218 )
Neutrophil extracellular trap formation (hsa04613 )
Alzheimer disease (hsa05010 )
Parkinson disease (hsa05012 )
Huntington disease (hsa05016 )
Spinocerebellar ataxia (hsa05017 )
Prion disease (hsa05020 )
Pathways of neurodegeneration - multiple diseases (hsa05022 )
Influenza A (hsa05164 )
Human T-cell leukemia virus 1 infection (hsa05166 )
Chemical carcinogenesis - reactive oxygen species (hsa05208 )
Diabetic cardiomyopathy (hsa05415 )

Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 7.92E-01 1.20E-02 1.01E-01
Adrenocortical carcinoma 2D11.Z Kidney 2.58E-01 7.04E-02 6.16E-01
Alopecia ED70 Skin from scalp 1.37E-01 3.74E-02 1.04E-01
Alzheimer's disease 8A20 Entorhinal cortex 2.99E-01 2.73E-03 2.59E-02
Ankylosing spondylitis FA92.0 Pheripheral blood 5.18E-01 5.28E-03 6.67E-02
Aortic stenosis BB70 Calcified aortic valve 8.66E-01 -5.96E-03 -3.37E-02
Apnea 7A40 Hyperplastic tonsil 6.33E-01 7.70E-02 1.23E+00
Arthropathy FA00-FA5Z Peripheral blood 7.43E-01 -1.81E-02 -1.89E-01
Asthma CA23 Nasal and bronchial airway 6.28E-01 1.03E-02 7.36E-02
Atopic dermatitis EA80 Skin 1.33E-02 7.39E-02 9.35E-01
Autism 6A02 Whole blood 3.05E-01 -2.99E-02 -3.38E-01
Autoimmune uveitis 9A96 Peripheral monocyte 5.77E-01 1.51E-02 1.48E-01
Autosomal dominant monocytopenia 4B04 Whole blood 9.37E-01 3.88E-02 2.33E-01
Bacterial infection of gingival 1C1H Gingival tissue 7.62E-01 -4.97E-03 -5.17E-02
Batten disease 5C56.1 Whole blood 3.87E-01 1.12E-01 1.60E+00
Behcet's disease 4A62 Peripheral blood 6.40E-02 1.79E-03 1.33E-02
Bipolar disorder 6A60-6A6Z Prefrontal cortex 9.93E-01 -1.53E-02 -1.33E-01
Bladder cancer 2C94 Bladder tissue 2.69E-01 -5.16E-02 -3.53E-01
Breast cancer 2C60-2C6Z Breast tissue 7.21E-01 -3.51E-03 -3.23E-02
Cardioembolic stroke 8B11.20 Whole blood 1.39E-01 1.85E-03 1.26E-02
Cervical cancer 2C77 Cervical tissue 6.04E-01 -9.53E-03 -6.80E-02
Childhood onset rheumatic disease FA20.Z Peripheral blood 6.26E-01 6.51E-03 6.13E-02
Chronic hepatitis C 1E51.1 Whole blood 8.14E-02 8.92E-02 5.96E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 6.18E-01 6.48E-03 5.69E-02
Chronic obstructive pulmonary disease CA22 Small airway epithelium 3.16E-01 -3.72E-03 -3.56E-02
Chronic rhinosinusitis CA0A Sinus mucosa tissue 4.76E-02 1.15E-01 1.12E+00
Colon cancer 2B90 Colon tissue 5.94E-03 4.64E-02 3.15E-01
Coronary artery disease BA80-BA8Z Peripheral blood 5.68E-01 1.21E-02 4.03E-02
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 9.33E-01 2.71E-02 2.55E-01
Endometriosis GA10 Endometrium tissue 3.91E-01 -5.37E-03 -6.22E-02
Familial hypercholesterolemia 5C80.00 Peripheral blood 1.27E-01 -6.64E-02 -1.03E+00
Familial hypercholesterolemia 5C80.00 Whole blood 2.68E-01 -9.08E-03 -9.45E-02
Gastric cancer 2B72 Gastric tissue 2.40E-01 1.30E-01 1.24E+00
Glioblastopma 2A00.00 Nervous tissue 3.92E-02 2.42E-02 1.58E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 1.48E-01 1.24E-02 1.41E-01
Head and neck cancer 2D42 Head and neck tissue 8.52E-01 4.40E-03 4.42E-02
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 1.22E-01 -7.65E-02 -6.74E-01
Huntington's disease 8A01.10 Whole blood 6.09E-02 -2.61E-02 -3.00E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 8.12E-01 -8.17E-02 -1.06E+00
Immunodeficiency 4A00-4A20 Peripheral blood 1.72E-01 7.09E-02 1.58E+00
Influenza 1.00E+30 Whole blood 4.81E-01 3.24E-02 4.63E-01
Interstitial cystitis GC00.3 Bladder tissue 7.20E-01 -1.94E-02 -2.36E-01
Intracranial aneurysm 8B01.0 Intracranial artery 4.99E-01 1.82E-02 1.45E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 3.16E-01 -2.68E-02 -1.25E-01
Ischemic stroke 8B11 Peripheral blood 6.99E-02 -3.56E-02 -3.47E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 2.44E-01 -1.10E-02 -2.69E-02
Lateral sclerosis 8B60.4 Cervical spinal cord 8.64E-02 1.04E-01 6.24E-01
Lateral sclerosis 8B60.4 Skin 5.06E-02 1.65E-01 1.68E+00
Liver cancer 2C12.0 Liver tissue 4.40E-01 -2.35E-02 -1.93E-01
Liver failure DB99.7-DB99.8 Liver tissue 5.74E-01 -3.82E-02 -2.54E-01
Lung cancer 2C25 Lung tissue 4.45E-09 4.57E-02 4.69E-01
Lupus erythematosus 4A40 Whole blood 4.84E-01 -1.12E-03 -6.39E-03
Major depressive disorder 6A70-6A7Z Whole blood 6.68E-01 -8.19E-04 -4.39E-03
Major depressive disorder 6A70-6A7Z Hippocampus 4.40E-01 1.10E-02 9.26E-02
Melanoma 2C30 Skin 5.00E-01 -2.41E-02 -1.41E-01
Multiple myeloma 2A83.1 Bone marrow 8.15E-01 -2.58E-02 -5.60E-01
Multiple myeloma 2A83.1 Peripheral blood 9.59E-01 6.05E-03 7.58E-02
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 6.01E-01 9.04E-02 3.85E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 4.03E-01 3.93E-02 3.67E-01
Myelofibrosis 2A20.2 Whole blood 3.54E-01 1.69E-02 2.19E-01
Myocardial infarction BA41-BA50 Peripheral blood 5.12E-01 5.42E-02 2.78E-01
Myopathy 8C70.6 Muscle tissue 9.64E-01 -2.53E-03 -1.08E-02
Neonatal sepsis KA60 Whole blood 1.90E-05 5.59E-02 6.09E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 8.97E-02 3.37E-02 5.07E-01
Non-alcoholic fatty liver disease DB92 Liver tissue 8.08E-02 1.18E-01 1.72E+00
Obesity related type 2 diabetes 5A11 Omental adipose tissue 9.56E-02 3.43E-02 6.80E-01
Olive pollen allergy CA08.00 Peripheral blood 2.41E-01 2.48E-02 7.63E-01
Oral cancer 2B6E Oral tissue 2.36E-04 6.21E-02 7.24E-01
Osteoarthritis FA00-FA0Z Synovial tissue 9.42E-01 8.62E-02 4.46E-01
Osteoporosis FB83.1 Bone marrow 3.47E-01 4.20E-02 5.04E-01
Ovarian cancer 2C73 Ovarian tissue 1.61E-01 -1.61E-01 -9.95E-01
Pancreatic cancer 2C10 Pancreas 1.56E-02 -1.59E-01 -7.98E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 6.54E-01 -8.31E-03 -9.94E-02
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 8.27E-01 -6.92E-03 -6.89E-02
Pituitary cancer 2D12 Pituitary tissue 9.64E-01 -4.45E-02 -3.26E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 9.78E-01 1.51E-03 7.46E-03
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 7.47E-01 6.45E-03 4.98E-02
Polycythemia vera 2A20.4 Whole blood 2.43E-01 2.62E-02 3.41E-01
Pompe disease 5C51.3 Biceps muscle 9.45E-01 -4.38E-02 -3.55E-01
Preterm birth KA21.4Z Myometrium 3.86E-01 1.13E-01 7.85E-01
Prostate cancer 2C82 Prostate 1.30E-01 -8.47E-02 -5.12E-01
Psoriasis EA90 Skin 7.59E-04 -8.12E-02 -3.18E-01
Rectal cancer 2B92 Rectal colon tissue 5.52E-01 -2.05E-02 -3.10E-01
Renal cancer 2C90-2C91 Kidney 7.74E-01 -1.84E-02 -1.57E-01
Retinoblastoma 2D02.2 Uvea 3.22E-02 -7.12E-02 -8.97E-01
Rheumatoid arthritis FA20 Synovial tissue 4.23E-02 -1.65E-01 -6.01E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 6.04E-01 1.35E-03 1.86E-02
Schizophrenia 6A20 Prefrontal cortex 6.30E-01 -1.45E-04 -1.10E-03
Schizophrenia 6A20 Superior temporal cortex 9.54E-01 -2.00E-03 -3.05E-02
Scleroderma 4A42.Z Whole blood 1.28E-01 2.25E-02 2.59E-01
Seizure 8A60-8A6Z Whole blood 2.72E-01 -1.04E-01 -1.01E+00
Sensitive skin EK0Z Skin 1.82E-02 1.61E-01 1.85E+00
Sepsis with septic shock 1G41 Whole blood 6.00E-01 1.97E-03 1.59E-02
Shwachman-Diamond syndrome 3A70.0 Bone marrow 4.61E-01 -5.16E-02 -5.24E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 9.80E-03 1.57E-01 1.27E+00
Simpson golabi behmel syndrome LD2C Adipose tissue 4.38E-03 1.50E-01 3.07E+00
Sjogren's syndrome 4A43.2 Salivary gland tissue 9.45E-01 -1.91E-02 -1.13E+00
Skin cancer 2C30-2C3Z Skin 3.66E-01 1.36E-03 7.87E-03
Thrombocythemia 3B63 Whole blood 1.91E-01 3.34E-02 4.11E-01
Thrombocytopenia 3B64 Whole blood 2.55E-01 1.01E-02 9.77E-02
Thyroid cancer 2D10 Thyroid 1.86E-01 -1.68E-03 -1.07E-02
Tibial muscular dystrophy 8C75 Muscle tissue 9.36E-01 2.32E-02 1.94E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 7.29E-01 7.19E-02 3.30E-01
Type 2 diabetes 5A11 Liver tissue 8.83E-01 -7.51E-02 -6.23E-01
Ureter cancer 2C92 Urothelium 1.21E-01 -3.28E-02 -2.66E-01
Uterine cancer 2C78 Endometrium tissue 1.19E-05 4.11E-02 3.35E-01
Vitiligo ED63.0 Skin 8.79E-01 -9.15E-02 -6.21E-01
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