Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT0J5KQ)

• DTT Name: FK506-binding protein 5 (FKBP5)
• Synonyms: Peptidyl-prolyl cis-trans isomerase FKBP5; PPIase FKBP5; HSP90-binding immunophilin; FKBP54; FKBP51; FKBP-51; FKBP-5; FF1 antigen; Androgen-regulated protein 6; AIG6; 54 kDa progesterone receptor-associated immunophilin; 51 kDa FKBP; 51 kDa FK506-binding protein
• Gene Name: FKBP5
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Cis-trans-isomerase
• UniProt ID: FKBP5_HUMAN
• TTD ID: T98337
• EC Number: EC 5.2.1.8
• Sequence:
  MTTDEGAKNNEESPTATVAEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGK
  LSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLP
  KIPSNATLFFEIELLDFKGEDLFEDGGIIRRTKRKGEGYSNPNEGATVEIHLEGRCGGRM
  FDCRDVAFTVGEGEDHDIPIGIDKALEKMQREEQCILYLGPRYGFGEAGKPKFGIEPNAE
  LIYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEM
  EYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEA
  QLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRRIYANMFKKFAEQD
  AKEEANKAMGKKTSEGVTNEKGTDSQAMEEEKPEGHV
• Function: Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Immunophilin protein with PPIase and co-chaperone activities.
• KEGG Pathway: Estrogen signaling pathway (hsa04915)
• Reactome Pathway:
  ESR-mediated signaling (R-HSA-8939211)
  MECP2 regulates neuronal receptors and channels (R-HSA-9022699)
  HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (R-HSA-3371497)

References

• [1] Biomarkers for eosinophilic esophagitis: a review. Ann Allergy Asthma Immunol. 2012 Sep;109(3):155-9.