Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT0NL6U)

DTT Name Annexin A10 (ANXA10)
Synonyms Annexin-14; Annexin-10; ANX14
Gene Name ANXA10
DTT Type
Literature-reported target
 [1]
BioChemical Class
Annexin protein
UniProt ID
ANX10_HUMAN
TTD ID
T86025
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFCGDYVQGTIFPAPNFNPIMDAQMLGGALQGFDCDKDMLINILTQRCNAQRMMIAEAYQ
SMYGRDLIGDMREQLSDHFKDVMAGLMYPPPLYDAHELWHAMKGVGTDENCLIEILASRT
NGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNLVQGTREEGYTDPAMAAQDAMVL
WEACQQKTGEHKTMLQMILCNKSYQQLRLVFQEFQNISGQDMVDAINECYDGYFQELLVA
IVLCVRDKPAYFAYRLYSAIHDFGFHNKTVIRILIARSEIDLLTIRKRYKERYGKSLFHD
IRNFASGHYKKALLAICAGDAEDY
Function
The expression of the tissue- and tumor-restricted ANXA10 is a marker of liver cell differentiation and growth arrest, and its down-regulation associated with malignant phenotype of hepatocytes, vascular invasion, and progression of HCC, leading to poor prognosis.

References

1 Down-regulation of annexin A10 in hepatocellular carcinoma is associated with vascular invasion, early recurrence, and poor prognosis in synergy wi... Am J Pathol. 2002 May;160(5):1831-7.