Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT0PSN6)

• DTT Name: Sprouty homolog 1 (SPRY-1)
• Synonyms: Spry-1; Protein sprouty homolog 1
• Gene Name: SPRY1
• DTT Type: Literature-reported target; [1]
• UniProt ID: SPY1_HUMAN
• TTD ID: T76540
• Sequence:
  MDPQNQHGSGSSLVVIQQPSLDSRQRLDYEREIQPTAILSLDQIKAIRGSNEYTEGPSVV
  KRPAPRTAPRQEKHERTHEIIPINVNNNYEHRHTSHLGHAVLPSNARGPILSRSTSTGSA
  ASSGSNSSASSEQGLLGRSPPTRPVPGHRSERAIRTQPKQLIVDDLKGSLKEDLTQHKFI
  CEQCGKCKCGECTAPRTLPSCLACNRQCLCSAESMVEYGTCMCLVKGIFYHCSNDDEGDS
  YSDNPCSCSQSHCCSRYLCMGAMSLFLPCLLCYPPAKGCLKLCRRCYDWIHRPGCRCKNS
  NTVYCKLESCPSRGQGKPS
• Function: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
• Reactome Pathway: EGFR downregulation (R-HSA-182971)

References

• [1] Sprouty1, a new target of the angiostatic agent 16K prolactin, negatively regulates angiogenesis. Mol Cancer. 2010 Sep 2;9:231.