Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT0QUFV)

DTT Name Vascular endothelial growth factor C (VEGFC)
Synonyms Vascular endothelial growth factor-related protein; VRP; VEGF-C; Flt4-L; Flt4 ligand
Gene Name VEGFC
DTT Type
Clinical trial target
 [1]
BioChemical Class
Growth factor
UniProt ID
VEGFC_HUMAN
TTD ID
T51425
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHLLGFFSVACSLLAAALLPGPREAPAAAAAFESGLDLSDAEPDAGEATAYASKDLEEQL
RSVSSVDELMTVLYPEYWKMYKCQLRKGGWQHNREQANLNSRTEETIKFAAAHYNTEILK
SIDNEWRKTQCMPREVCIDVGKEFGVATNTFFKPPCVSVYRCGGCCNSEGLQCMNTSTSY
LSKTLFEITVPLSQGPKPVTISFANHTSCRCMSKLDVYRQVHSIIRRSLPATLPQCQAAN
KTCPTNYMWNNHICRCLAQEDFMFSSDAGDDSTDGFHDICGPNKELDEETCQCVCRAGLR
PASCGPHKELDRNSCQCVCKNKLFPSQCGANREFDENTCQCVCKRTCPRNQPLNPGKCAC
ECTESPQKCLLKGKKFHHQTCSCYRRPCTNRQKACEPGFSYSEEVCRCVPSYWKRPQMS
Function
May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors. Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels.
KEGG Pathway
Ras signaling pathway (hsa04014 )
Rap1 signaling pathway (hsa04015 )
Cytokine-cytokine receptor interaction (hsa04060 )
PI3K-Akt signaling pathway (hsa04151 )
Focal adhesion (hsa04510 )
TNF signaling pathway (hsa04668 )
Pathways in cancer (hsa05200 )
Reactome Pathway
VEGF ligand-receptor interactions (R-HSA-194313 )
VEGF binds to VEGFR leading to receptor dimerization (R-HSA-195399 )
Platelet degranulation (R-HSA-114608 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
OPT-302 DMS4XFI Diabetic macular edema 9B71.02 Phase 2 [2]
VGX-100 DM9GC4R Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
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References

1 National Cancer Institute Drug Dictionary (drug id 724066).
2 Clinical pipeline report, company report or official report of Opthea.