Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT13GFV)

DTT Name Follicle stimulating hormone (FSHB)
Synonyms Follitropin subunit beta; Follitropin beta chain; Follicle-stimulating hormone beta subunit; FSH-beta; FSH-B
Gene Name FSHB
DTT Type
Clinical trial target
 [1]
BioChemical Class
Hormone
UniProt ID
FSHB_HUMAN
TTD ID
T10092
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKTLQFFFLFCCWKAICCNSCELTNITIAIEKEECRFCISINTTWCAGYCYTRDLVYKDP
ARPKIQKTCTFKELVYETVRVPGCAHHADSLYTYPVATQCHCGKCDSDSTDCTVRGLGPS
YCSFGEMKE
Function
Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs.
KEGG Pathway
Neuroactive ligand-receptor interaction (hsa04080 )
GnRH signaling pathway (hsa04912 )
Ovarian steroidogenesis (hsa04913 )
Prolactin signaling pathway (hsa04917 )
Thyroid hormone synthesis (hsa04918 )
Autoimmune thyroid disease (hsa05320 )
Reactome Pathway
Hormone ligand-binding receptors (R-HSA-375281 )
G alpha (s) signalling events (R-HSA-418555 )
Thyroxine biosynthesis (R-HSA-209968 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Follicle stimulating hormone DMJNO3D Infertility GB04 Phase 2 [1]
AKP-501 DM9JU8L Female infertility GA31.Z Phase 1 [2]
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References

1 Company report (Glycotope)
2 AKR-501 (YM477) a novel orally-active thrombopoietin receptor agonist. Eur J Haematol. 2009 Apr;82(4):247-54.