Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT18WJB)

DTT Name	Vang-like protein 1 (VANGL1)
Synonyms	Van Gogh-like protein 1; Strabismus 2; STB2; Loop-tail protein 2 homolog; LPP2
Gene Name	VANGL1
DTT Type	Literature-reported target	[1]
UniProt ID	VANG1_HUMAN
TTD ID	T38183
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MDTESTYSGYSYYSSHSKKSHRQGERTRERHKSPRNKDGRGSEKSVTIQPPTGEPLLGND STRTEEVQDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLG LLVFLTPIAFILLPPILWRDELEPCGTICEGLFISMAFKLLILLIGTWALFFRKRRADMP RVFVFRALLLVLIFLFVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIVL LELRQLQPMFTLQVVRSTDGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKF RAAKHMAGLKVYNVDGPSNNATGQSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRKAR LVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREAAQAIFPSMARALQKYLRITRQQNYHSM ESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIV FVLKCLDFSLVVNVKKIPFIILSEEFIDPKSHKFVLRLQSETSV
Function	Invovled in multicellular organism development, Wnt signaling pathway and planar cell polarity pathway.
KEGG Pathway	Wnt signaling pathway (hsa04310 )
Reactome Pathway	RHOB GTPase cycle (R-HSA-9013026 ) RHOC GTPase cycle (R-HSA-9013106 ) CDC42 GTPase cycle (R-HSA-9013148 ) RAC1 GTPase cycle (R-HSA-9013149 ) RAC2 GTPase cycle (R-HSA-9013404 ) RHOD GTPase cycle (R-HSA-9013405 ) RHOQ GTPase cycle (R-HSA-9013406 ) RHOH GTPase cycle (R-HSA-9013407 ) RHOG GTPase cycle (R-HSA-9013408 ) RHOJ GTPase cycle (R-HSA-9013409 ) RHOU GTPase cycle (R-HSA-9013420 ) RAC3 GTPase cycle (R-HSA-9013423 ) RHOV GTPase cycle (R-HSA-9013424 ) RHOF GTPase cycle (R-HSA-9035034 ) RND3 GTPase cycle (R-HSA-9696264 ) RND2 GTPase cycle (R-HSA-9696270 ) RND1 GTPase cycle (R-HSA-9696273 ) RHOA GTPase cycle (R-HSA-8980692 )

References

1	Isolation and characterization of a novel human gene, VANGL1, as a therapeutic target for hepatocellular carcinoma. Int J Oncol. 2002 Jun;20(6):1173-8.