| DTT Name |
HUMAN toll-like receptor 3 (TLR3)
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| Synonyms |
CD283 |
| Gene Name |
TLR3
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| BioChemical Class |
Toll-like receptor
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| UniProt ID |
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| TTD ID |
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| 3D Structure |
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| Sequence |
MRQTLPCIYFWGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTH
NQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFA
FCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSN
NKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEK
LCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQL
EYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHL
NMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKIS
KIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVP
SLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHN
NLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNT
LPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNW
INETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIV
LLIHFEGWRISFYWNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVWEHFSSMEKE
DQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAI
EQNLDSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSK
NSVH
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| Function |
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.
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| KEGG Pathway |
- Necroptosis (hsa04217 )
- Toll-like receptor signaling pathway (hsa04620 )
- Hepatitis C (hsa05160 )
- Hepatitis B (hsa05161 )
- Influenza A (hsa05164 )
- Human papillomavirus infection (hsa05165 )
- Kaposi sarcoma-associated herpesvirus infection (hsa05167 )
- Herpes simplex virus 1 infection (hsa05168 )
- Coronavirus disease - COVID-19 (hsa05171 )
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| Reactome Pathway |
- Toll Like Receptor 3 (TLR3) Cascade (R-HSA-168164 )
- TICAM1, RIP1-mediated IKK complex recruitment (R-HSA-168927 )
- RIP-mediated NFkB activation via ZBP1 (R-HSA-1810476 )
- TLR3 deficiency - HSE (R-HSA-5602410 )
- UNC93B1 deficiency - HSE (R-HSA-5602415 )
- TICAM1 deficiency - HSE (R-HSA-5602566 )
- TRAF3 deficiency - HSE (R-HSA-5602571 )
- TLR3-mediated TICAM1-dependent programmed cell death (R-HSA-9013957 )
- TICAM1-dependent activation of IRF3/IRF7 (R-HSA-9013973 )
- TICAM1,TRAF6-dependent induction of TAK1 complex (R-HSA-9014325 )
- Trafficking and processing of endosomal TLR (R-HSA-1679131 )
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