Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT1GLAJ)

DTT Name	Lactadherin (MFGE8)
Synonyms	Milk fat globule-EGF factor 8; MFGM; MFGE8; MFG-E8; Human milk fat globule membrane protein BA46; HMFG; Breast epithelial antigen BA46
Gene Name	MFGE8
DTT Type	Literature-reported target	[1]
BioChemical Class	Growth factor
UniProt ID	MFGM_HUMAN
TTD ID	T22538
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MPRPRLLAALCGALLCAPSLLVALDICSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKG YAGNHCETKCVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPS SNDDNPWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHK EFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNS IPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQVDLGSSKEVT GIITQGARNFGSVQFVASYKVAYSNDSANWTEYQDPRTGSSKIFPGNWDNHSHKKNLFET PILARYVRILPVAWHNRIALRLELLGC
Function	Medin is the main constituent of aortic medial amyloid.
Reactome Pathway	Post-translational protein phosphorylation (R-HSA-8957275 ) Amyloid fiber formation (R-HSA-977225 ) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (R-HSA-381426 )

References

1	Characterization of novel breast carcinoma-associated BA46-derived peptides in HLA-A2.1/D(b)-beta2m transgenic mice. J Clin Invest. 2002 Aug;110(4):453-62.