Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT1NMGV)

• DTT Name: DEK protein (DEK)
• Synonyms: Protein DEK
• Gene Name: DEK
• DTT Type: Literature-reported target; [1]
• UniProt ID: DEK_HUMAN
• TTD ID: T28758
• Sequence:
  MSASAPAAEGEGTPTQPASEKEPEMPGPREESEEEEDEDDEEEEEEEKEKSLIVEGKREK
  KKVERLTMQVSSLQREPFTIAQGKGQKLCEIERIHFFLSKKKTDELRNLHKLLYNRPGTV
  SSLKKNVGQFSGFPFEKGSVQYKKKEEMLKKFRNAMLKSICEVLDLERSGVNSELVKRIL
  NFLMHPKPSGKPLPKSKKTCSKGSKKERNSSGMARKAKRTKCPEILSDESSSDEDEKKNK
  EESSDDEDKESEEEPPKKTAKREKPKQKATSKSKKSVKSANVKKADSSTTKKNQNSSKKE
  SESEDSSDDEPLIKKLKKPPTDEELKETIKKLLASANLEEVTMKQICKKVYENYPTYDLT
  ERKDFIKTTVKELIS
• Function: Involved in chromatin organization.
• Reactome Pathway:
  Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (R-HSA-8864260)
  Transcriptional regulation of granulopoiesis (R-HSA-9616222)
  B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

References

• [1] DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis. Nat Commun. 2017 Feb 6;8:14252.